The Relationship between Serum Vitamin D and Chronic Rhinosinusitis: A Systematic Review

Background: Chronic rhinosinusitis (CRS) places a relatively large socioeconomic burden on developed nations, yet remains a difficult disease to treat. Vitamin D3 (VD3) deficiency is reported to be associated with increased incidence of allergic airway diseases. The ability of VD3 to augment innate and adaptive immune responses has sparked interest in its immunologic role in allergy. The objective of the present study is to evaluate the relationship between serum vitamin D level and chronic rhinosinusitis.Methods: Total 90 patients were included in the study and divided into three groups i.e., 30 patients of chronicrhinosinusitis with nasal polyposis (CRSwNP), 30 patients of chronic rhinosinusitis without nasal polyposis (CRSsNP) and 30 healthy subjects were used as control. The severity of CRSwNP was assessed with the Lund-Mackay (LM) score and polyp grading system. VD3 status was assessed by measuring circulating 25-hydroxyvitamin D (25OHD) by using ELISA. Results: Serum 25OHD levels (ng/ml±SD) were significantly lower in patients with CRSwNP (16.16±8.86) than in those with CRSsNP (23.28±5.35; p=0.001) and control 44.37±19.87. The incidence of vitamin D deficiency (<20 ng/ml) in CRSwNP and CRSsNP patients were 60% and 20%; however, the incidence of vitamin D insufficiency (20-30 ng/ml) in these patients were 37% and 70%, respectively. A significantly inverse relationship was found between serum 25OHD level and polyp grade (p=0.048), indicating lower serum 25OHD was associated with higher polyp grade. Serum 25OHD was inversely related to both LM endoscopic and LM CT scan score, which is found to be significant (p=0.001).Conclusions: The available evidence indicates that there is a significant relationship between low VD3 levels and CRSwNP phenotype. Lower 25VD3 levels were associated with more severe mucosal inflammation on nasal endocscoy and CT scan.

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The relationship between preoperative serum vitamin D deficiency and postoperative atrial fibrillation: A systematic review and meta-analysis

Journal of Cardiovascular and Thoracic Research ◽

10.34172/jcvtr.2021.25 ◽

2021 ◽

Vol 13 (2) ◽

pp. 102-108

Author(s):

Mehran Rahimi ◽

Mohammadreza Taban-Sadeghi ◽

Leila Nikniaz ◽

Fariba Pashazadeh

Keyword(s):

Atrial Fibrillation ◽

Systematic Review ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Meta Analysis ◽

Serum Vitamin ◽

Postoperative Atrial Fibrillation ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

The Relationship

Postoperative atrial fibrillation (POAF) is the most common arrhythmia seen in the first days following cardiac surgeries. Recently, there is a growing discussion regarding the link between vitamin D deficiency and POAF development. This systematic review and meta-analysis of the observational studies aimed at evaluating the association between preoperative vitamin D deficiency and Postoperative atrial fibrillation. In this study, using PubMed, Scopus, Google Scholar, EMBASE, Web of Science, and Cochrane Libraries, we searched for records published before July 2020. Two reviewers screened for studies that examined the relationship between preoperative vitamin D levels and the generation of POAF. Data regarding study design, patient characteristics, definition of atrial fibrillation (AF) , type of surgery, vitamin D levels, and measurement methods were extracted. Five studies were included in the meta-analysis. Our primary analysis showed a significant relationship between preoperative levels of vitamin D and POAF development (mean differences (MD) = -2.851, 95% confidence interval (CI) =-5.506 to -0.195; P value 0.035). Our meta-analysis suggested serum vitamin D deficiency is associated with an increased risk of POAF development. Further large scale interventional studies are needed to explore whether vitamin D supplementation will prevent POAF.

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The relationship between serum vitamin D and HOMA-IR in overweight elderly patients

International Journal of Cardiology ◽

10.1016/j.ijcard.2014.09.197 ◽

2014 ◽

Vol 177 (3) ◽

pp. 1100-1102 ◽

Cited By ~ 1

Author(s):

Hongfeng Jiang ◽

Shaorong Peng

Keyword(s):

Vitamin D ◽

Elderly Patients ◽

Serum Vitamin ◽

Serum Vitamin D ◽

The Relationship

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The relationship between serum vitamin D levels and sleep quality in fixed day indoor field workers in the electronics manufacturing industry in Korea

Annals of Occupational and Environmental Medicine ◽

10.1186/s40557-017-0187-7 ◽

2017 ◽

Vol 29 (1) ◽

Cited By ~ 13

Author(s):

Young Saeng Jung ◽

Chang Ho Chae ◽

Young Ouk Kim ◽

Jun Seok Son ◽

Chan Woo Kim ◽

...

Keyword(s):

Vitamin D ◽

Sleep Quality ◽

Manufacturing Industry ◽

Serum Vitamin ◽

Electronics Manufacturing ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Field Workers ◽

The Relationship

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Causal analysis shows evidence of atopic dermatitis leading to an increase in vitamin D levels

10.1101/2020.04.22.20075077 ◽

2020 ◽

Author(s):

Daniel R Drodge ◽

Ashley Budu-Aggrey ◽

Lavinia Paternoster

Keyword(s):

Vitamin D ◽

Atopic Dermatitis ◽

Serum Vitamin ◽

Strong Relationship ◽

Reverse Direction ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Standard Deviations ◽

The Relationship ◽

Gwa Studies

AbstractAtopic dermatitis (AD) patients have been observed to have lower vitamin D levels. Previous studies have found little evidence that vitamin D levels causally influence the risk of AD, but the reverse direction has not yet been investigated.Here we used Mendelian Randomization to assess the causal relationship between AD and serum vitamin D levels, using genetic data from the most recent GWA studies of vitamin D and AD.There was little evidence for vitamin D levels causally influencing AD risk (odds per standard deviations increase in log-transformed vitamin D levels =1.233, 95% CI 0.927 to 1.639, P-value =0.150). However, genetic liability for AD raises serum vitamin D levels by 0.043 (95% CI 0.017 to 0.069) standard deviations per doubling of odds of disease (P-value =0.001). The AD-associated filaggrin (FLG) mutation R501X appears to show a particularly strong relationship with vitamin D. However, the relationship between AD and vitamin D holds when R501X is omitted (0.018, 95% CI 0.004 to 0.031, P-value =0.008).We found evidence that AD is causally associated with an increase in serum vitamin D levels. Whilst the AD-associated FLG gene has a particularly strong relationship with vitamin D, other AD SNPs show a consistent direction of effect, suggesting that AD more generally influences serum vitamin D levels.

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