scholarly journals Beware of the Caterpillar: Anaphylaxis to the Spotted Tussock Moth Caterpillar, Lophocampa Maculata

2014 ◽  
Vol 5 (2) ◽  
pp. ar.2014.5.0086 ◽  
Author(s):  
Brandon DuGar ◽  
Julie Sterbank ◽  
Haig Tcheurekdjian ◽  
Robert Hostoffer
Keyword(s):  
Case Report ◽  
Anaphylactic Reaction ◽  
Immunoglobulin E ◽  
Type I ◽  
Pathophysiological Mechanism ◽  
Scratch Testing ◽  
Tussock Moth ◽  
Prompt Treatment ◽  
Progressive Dyspnea ◽  
Type I Hypersensitivity

We present a case report of a 5-year-old boy with presumed anaphylaxis to the caterpillar, Lophocampa maculata, manifesting as the acute development of diffuse urticaria and progressive dyspnea. This reaction required prompt treatment with antihistamines and a bronchodilator. Allergen scratch testing with a homogenized caterpillar extract suggests that immunoglobulin E–mediated type I hypersensitivity as the pathophysiological mechanism responsible for the boy's anaphylaxis. This case report represents the first documented occurrence of an anaphylactic reaction to Lophocampa maculata and adds to the rare incidence of documented hypersensitivity to the order Lepidoptera.

Effects of magnolialide isolated from the leaves of Laurus nobilis L. (Lauraceae) on immunoglobulin E-mediated type I hypersensitivity in vitro

2013 ◽  
Vol 149 (2) ◽  
pp. 550-556 ◽  
Author(s):  
Taehun Lee ◽  
Sooryun Lee ◽  
Kyeong Ho Kim ◽  
Ki-Bong Oh ◽  
Jongheon Shin ◽  
...  
Keyword(s):  
Immunoglobulin E ◽  
Type I ◽  
Laurus Nobilis ◽  
Type I Hypersensitivity

Biomarkers for non-human primate Type-I hypersensitivity: Antigen-specific immunoglobulin E assays

2013 ◽  
Vol 392 (1-2) ◽  
pp. 29-37 ◽  
Author(s):  
Darcey Clark ◽  
Faith Shiota ◽  
Carla Forte ◽  
Padma Narayanan ◽  
Daniel T. Mytych ◽  
...  
Keyword(s):  
Immunoglobulin E ◽  
Type I ◽  
Specific Immunoglobulin E ◽  
Specific Immunoglobulin ◽  
Type I Hypersensitivity ◽  
Human Primate

scholarly journals Fungal allergens.

1995 ◽  
Vol 8 (2) ◽  
pp. 161-179 ◽  
Author(s):  
W E Horner ◽  
A Helbling ◽  
J E Salvaggio ◽  
S B Lehrer
Keyword(s):  
Immunoglobulin E ◽  
Fungal Spores ◽  
Pollen Grains ◽  
Type I ◽  
Fungal Allergens ◽  
Fungal Allergy ◽  
Airborne Fungal Spores ◽  
Specific Antigens ◽  
Type I Hypersensitivity ◽  
Allergy Prevalence

Airborne fungal spores occur widely and often in far greater concentrations than pollen grains. Immunoglobulin E-specific antigens (allergens) on airborne fungal spores induce type I hypersensitivity (allergic) respiratory reactions in sensitized atopic subjects, causing rhinitis and/or asthma. The prevalence of respiratory allergy to fungi is imprecisely known but is estimated at 20 to 30% of atopic (allergy-predisposed) individuals or up to 6% of the general population. Diagnosis and immunotherapy of allergy to fungi require well-characterized or standardized extracts that contain the relevant allergen(s) of the appropriate fungus. Production of standardized extracts is difficult since fungal extracts are complex mixtures and a variety of fungi are allergenic. Thus, the currently available extracts are largely nonstandardized, even uncharacterized, crude extracts. Recent significant progress in isolating and characterizing relevant fungal allergens is summarized in the present review. Particularly, some allergens from the genera Alternaria, Aspergillus, and Cladosporium are now thoroughly characterized, and allergens from several other genera, including some basidiomycetes, have also been purified. The availability of these extracts will facilitate definitive studies of fungal allergy prevalence and immunotherapy efficacy as well as enhance both the diagnosis and therapy of fungal allergy.

scholarly journals Successful desensitization in patient with hypersensitivity to multiple Insulin preparations - case report

2020 ◽  
Author(s):  
Carina Petricău ◽  
Irena Nedelea ◽  
Diana Deleanu
Keyword(s):  
Case Report ◽  
Diabetic Patient ◽  
Human Insulin ◽  
Treatment Strategy ◽  
Type I ◽  
Insulin Analogs ◽  
The Past ◽  
First Case ◽  
Insulin Dependent ◽  
Type I Hypersensitivity

Hypersensitivity to insulin has decreased substantially in the past three decades, since purified human insulin was introduced to replace heterogeneous porcine and bovine preparations. However, human insulin and its analogs still have immunogenic potential that may prove detrimental for hypersensitive insulin-dependent diabetics. In cases of anaphylactic reactions to insulin, rapid desensitization may be considered as a treatment strategy. We present the first case of successful insulin desensitization in Romania for an uncontrolled diabetic patient with type I hypersensitivity to multiple insulin analogs.

Systemic Reactions to Immunotherapy: The American Academy of Otolaryngic Allergy Morbidity and Mortality Survey

1994 ◽  
Vol 110 (6) ◽  
pp. 487-493 ◽  
Author(s):  
Paul R. Cook ◽  
James L. Bryant ◽  
William E. Davis ◽  
Theodore T. Benke ◽  
Arnold S. Rapoport
Keyword(s):  
Hypersensitivity Reaction ◽  
American Academy ◽  
Nasal Obstruction ◽  
Reaction Rate ◽  
Immunoglobulin E ◽  
Systemic Reaction ◽  
Type I ◽  
Systemic Reactions ◽  
Type I Hypersensitivity ◽  
Mortality Survey

Anaphylaxis may be defined as a systemic, Immunoglobulin E-mediated (Gell-Coombs type I) hypersensitivity reaction triggered by exposure to an antigen in a previously sensitized patient. Anaphylaxis may occur in a varlety of circumstances: however, when it occurs as the result of Immunotherapy, it is of great concern to the practicing allergist. When describing or reporting anaphylaxis relating to Immunotherapy, most allergists speak in terms of the types of reactions, local vs. systemic. Germane to this discussion is the use of the term systemic reaction, which can mean anything from mild allergy symptoms resulting from an allergy injection to bradycardia and hypotension (shock). In this article we report serious or significant systemic reactions, which are characterized by any of the following symptoms: urticaria, sneezing or nasal obstruction, throat tightness or congestion, wheezing, and shock (bradycardta or hypotension). There were no fatalities reported from the survey group. The overall reaction rate was 0.3%.

scholarly journals IL-1βand IL-6 Are Highly Expressed in RF+IgE+ Systemic Lupus Erythematous Subtype

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Yongkang Wu ◽  
Bei Cai ◽  
Junlong Zhang ◽  
Beilei Shen ◽  
Zhuochun Huang ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Immunoglobulin E ◽  
Clinical Symptoms ◽  
Type I ◽  
Systemic Lupus Erythematous ◽  
Systemic Lupus ◽  
Key Indicator ◽  
Great Heterogeneity ◽  
Accurate Treatment ◽  
Type I Hypersensitivity

Background.Systemic lupus erythematosus (SLE) is an autoimmune disease with great heterogeneity in pathogenesis and clinical symptoms. Rheumatoid factor (RF) is one key indicator for rheumatoid arthritis (RA) while immunoglobulin E (IgE) is associated with type I hypersensitivity. To better categorize SLE subtypes, we determined the dominant cytokines based on familial SLE patients.Methods.RF, IgE, and multiple cytokines (i.e., IL-1β, IL-6, IL-8, IL-10, IL-17, IFN-γ, IP-10, MCP-1, and MIP-1β) were measured in sera of familial SLE patients (n=3), noninherited SLE patients (n=108), and healthy controls (n=80).Results.Three familial SLE patients and 5 noninherited SLE cases are with features of RF+IgE+. These RF+IgE+ SLE patients expressed significantly higher levels of IL-1βand IL-6 than the other SLE patients (P<0.05). IL-6 correlated with both IgE and IL-1βlevels in RF+IgE+ SLE patients (r2=0.583,P=0.027;r2=0.847,P=0.001), and IgE also correlated with IL-1β(r2=0.567,P=0.031).Conclusion.Both IL-1βand IL-6 are highly expressed cytokines in RF+IgE+ SLE subtype which may be related to the pathogenesis of this special SLE subtype and provide accurate treatment strategy by neutralizing IL-1βand IL-6.

scholarly journals Management of a Type I Hypersensitivity Reaction to IV Etoposide in a Woman with a Yolk Sac Tumor: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-2
Author(s):  
David Starks ◽  
Deborah Prinz ◽  
Amy Armstrong ◽  
Lindsay Means ◽  
Steven Waggoner ◽  
...  
Keyword(s):  
Case Report ◽  
Gynecologic Oncology ◽  
Yolk Sac ◽  
Yolk Sac Tumor ◽  
Type I ◽  
Hypersensitivity Reactions ◽  
Etoposide Phosphate ◽  
Type I Hypersensitivity ◽  
Substitute Drug ◽  
Severe Patient

Type I hypersensitivity reactions to intravenous administration of etoposide are extremely rare. Etoposide is an essential component of several chemotherapy regimens used in gynecologic oncology, and discontinuation of this drug during a course of treatment should only be due to severe patient intolerance. We report the successful use of intravenous etoposide phosphate as a substitute drug in a patient with a yolk sac tumor who manifested a Type I hypersensitivity to intravenous etoposide. The patient ultimately completed all 4 cycles of bleomycin, etoposide, cisplatin (BEP) using etoposide phosphate as a substitute drug.

scholarly journals Pollen Allergy; Mechanism and Etiology

2021 ◽  
Vol 1 (1) ◽  
pp. 16-19
Author(s):  
Shazia Choudhary ◽  
Mamoona Noreen ◽  
Muhammad Arshad ◽  
Muhammad Arshad
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Immunoglobulin E ◽  
Tissue Injury ◽  
Pollen Allergy ◽  
Type I ◽  
Pollen Allergens ◽  
Normal Healthy Individual ◽  
Foreign Molecule ◽  
Type I Hypersensitivity

The term allergy refers to an exaggerated immune response to a foreign molecule. In a normal healthy individual, this foreign molecule will act as a harmless antigen, as it will be recognized & cleared by the immune system without causing any significant damage to host tissues. In certain individuals, such antigens stimulate immune system in such a way that a series of exaggerated immune response are generated against it, leading to significant tissue injury and damage to the host. Such as exaggerated immune response may also cause death of the patient. Such antigen is termed as an allergen. Allergy is categorised under Immunoglobulin E (IgE) mediated type I hypersensitivity reactions. These reactions occur when an antigen acting as an allergen attacks the immune system of the host and causes excessive stimulation of mast cells and basophils. This is followed by the release of allergy mediators which are responsible for causing local or systemic anaphylaxis, allergic asthma, allergic rhinitis, conjuctivitis. Type I allergens are of various types, the mechanism of action is same; however underlying factors may differ in each type. This article is about pollen allergens, in specific & will discuss the common sources of pollen allergens in Pakistan, the relevance and the factors behind pollen allergy.   

scholarly journals Immediate allergic reaction to methylprednisolone with tolerance of other corticosteroids

2012 ◽  
Vol 140 (3-4) ◽  
pp. 233-235 ◽  
Author(s):  
Marina Atanaskovic-Markovic ◽  
Marija Gavrovic-Jankulovic ◽  
Srdja Jankovic ◽  
Gordan Blagojevic ◽  
Tanja Cirkovic-Velickovic ◽  
...  
Keyword(s):  
Allergic Reaction ◽  
Anaphylactic Reaction ◽  
Skin Testing ◽  
Cross Reactivity ◽  
Clinical Findings ◽  
Skin Tests ◽  
Type I ◽  
Positive Skin ◽  
Uncommon Case ◽  
Type I Hypersensitivity

Introduction. In spite of the wide usage of corticosteroids for the treatment of a plethora of diseases, sometimes they can induce immediate hypersensitivity reactions, which are however uncommon. Case Outline. We report a case of immediate allergic reaction induced by intravenous methylprednisolone given before operation for surgical repair of an arm contracture as a sequel of burns, which the child had tolerated a month before. Six weeks later the patient repeated the anaphylactic reaction during skin testing to methylprednisolone. In addition, basophile activation test with methylprednisolone (BAT) was positive. Conclusion. This case report describes a patient who experienced intraoperative anaphylaxis and anaphylactic reaction induced by skin testing. This is the first report on induction of both anaphylactic reactions by methylprednisolone in the same child. Clinical findings, positive BAT and positive skin tests with methylprednisolone imply that the child developed type-I hypersensitivity. The lack of cross-reactivity with other corticosteroids emphasizes that the reactions were caused by the steroid molecule.

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