Features of the structural and functional state of bone tissue in patients with generalized periodontitis who live in different anthropogenically loaded areas

2020 ◽  
Vol 33 (2) ◽  
Author(s):  
Khrystyna Kovalyshyn ◽  
Mykola Rozhko
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Metabolism ◽  
Bone Tissue ◽  
Functional State ◽  
Mineral Density ◽  
Tissue Mineral Density ◽  
Degree Of Severity

Introduction. A research was conducted of the features of the structural and functional state of bone tissue in patients with generalized periodontitis with rheumatoid arthritis who live in different anthropogenically loaded areas. Aim. The aim of the research is to assess the bone tissue mineral density according to the indicators of densitometric researches and the level of a marker of bone metabolism in generalized periodontitis of I and II degree of severity. Material and methods. We examined 105 patients with GP of the I and II degree of severity, among whom were patients with rheumatoid arthritis who live in environmentally favorable and unfavorable areas. Peculiarities of the structural and functional state of bone tissue were assessed using an ultrasonic densitometer Sunlight Mini Omni TM and the level of a marker of bone tissue resorption of deoxypyridinoline in urine. Results. Patients with generalized periodontitis with rheumatoid arthritis who live in environmentally unfavorable areas, found the largest number of people with signs of osteopenia, osteoporosis and elevated levels of deoxypyridinoline. In particular, in generalized periodontitis of the II degree of severity with osteopenia – 14 people (48.27%), with osteoporosis – 9 people (31%), the level of deoxypyridinoline determined in women was 12.03 ± 0.16 n/mol, which in 2.2 times significantly higher than the group of healthy (p < 0.001). Conclusions. According to densitometric parameters and the level of deoxypyridinoline in the urine, the acceleration of bone tissue resorption in patients with generalized periodontitis of the II degree of severity with rheumatoid arthritis who live in environmentally unfavorable areas was established.

Anti-TNFS effects on bone mineral density and bone metabolism in rheumatoid arthritis: Focus on etanercept

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S427
Author(s):  
C. Ancuta ◽  
E. Ancuta ◽  
C. Iordache ◽  
S. Miu ◽  
R. Chirieac
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Mineral Density

scholarly journals Life quality of men with ankylosing spondylitis: association with the disease course and the structural and functional state of bone tissue

2021 ◽  
Vol 11 (2) ◽  
pp. 70-78
Author(s):  
S.V. Shevchuk ◽  
O.M. Pavliuk
Keyword(s):  
Quality Of Life ◽  
Ankylosing Spondylitis ◽  
Bone Tissue ◽  
Functional State ◽  
Life Quality ◽  
Control Group ◽  
High Dose ◽  
Mineral Density ◽  
Sf 36

Background. Multiple peculiarities of ankylosing spondylitis clinical course have a significant influence on the phy­sical, mental and social status of patients. Systemic loss of bone tissue manifesting itself through the development of osteoporosis and its complications is not excluded either. However, currently there is no sufficiently clear information on the influence of osteoporosis or its metabolic components, as well as peculiarities of the disease clinical course on the physical and mental health components in the patients suffering from ankylosing spondylitis. Purpose: to study the quality of life indices using the SF-36 and HAQ questionnaires in men suffering from ankylosing spondylitis and to assess the associations of these indexes with the disease cli­nical course as well as structural and functional state of bone tissue. Materials and methods. 105 men suffering from ankylo­sing spondylitis and 25 practically healthy persons of the appropriate age and sex forming the control group were examined. In order to assess the quality of life indices, the SF-36 and HAQ questionnaires were used. Results. It was established that men suffering from ankylo­sing spondylitis showed reliably lower indices of phy­sical (37.3 ± 1.5 points) and mental (44.2 ± 1.7 points) health components if compared to the control group (99.1 ± 0.3; 97.4 ± 0.7 points respectively). Under conditions of the low bone mineral density, quality of life indices (PCS; MCS) were only 12.2–7.1 % lower than in the patients with a preserved bone mineral density. It was shown that under conditions of the Vitamin D deficiency, quality of life components were significantly worse, specifically on account of the mental health component (р < 0.05). It was also established that the lower quality of life was closely associa­ted with a high activity of the inflammatory process (ASDAS-СRP, BASDAI) and a high dose of glucocorticoids. Conclusions. Men suffering from ankylosing spondylitis show a significant reduction of life quality indices by the SF-36 (PCS; MCS) and HAQ questionnaires, which demonstrate no association with the age of the patients (except for MCS), di­sease form and duration, structural and functional state of bone tissue. However, they are significantly worse in subjects with the Vitamin D deficiency, a high dose of glucocorticoids and high disease activity.

scholarly journals Osteoporosis and antithrombotic therapy

2021 ◽  
Vol 26 (5) ◽  
pp. 4173
Author(s):  
N. V. Brailova ◽  
E. N. Dudinskaya ◽  
V. A. Kuznesova ◽  
O. N. Tkacheva
Keyword(s):  
Bone Mineral Density ◽  
Bone Metabolism ◽  
Bone Tissue ◽  
Bone Mineral ◽  
Vitamin K Antagonists ◽  
Oral Anticoagulants ◽  
Direct Oral Anticoagulants ◽  
Antiplatelet Agents ◽  
Mineral Density ◽  
Negative Effect

Anticoagulant and antiplatelet agents are used to prevent stroke and thromboembolic events. There is insufficient data on the effect of these drugs on bone tissue. In addition, the available data are ambiguous, which increases suspicion when used in individuals at high risk of osteoporosis. The article provides data on the effect of anticoagulant and antiplatelet agents on bone metabolism, bone mineral density and the fracture risk. Literature data indicate a negative effect of heparin on bone tissue, which is increase the risk of fractures. Low molecular weight heparins has lower effect on bone tissue than heparin. It is known that vitamin K antagonists significantly affect bone metabolism and markers of bone formation, however, data on the effect on bone mineral density and the risk of fractures are contradictory. Direct oral anticoagulants are relatively safe in relation to bone tissue. Data on the effects of antiplatelet drugs on bone are ambiguous.

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