scholarly journals The linguistic impairment of the perfect aspect in Alzheimer’s disease and logopenic primary progressive aphasia

2021 ◽  
Vol 2 (4) ◽  
pp. e528
Author(s):  
Jean Carlos da Silva Gomes ◽  
Adriana Leitão Martins ◽  
Fernanda de Carvalho Rodrigues
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Decline ◽  
Primary Progressive Aphasia ◽  
Recent Past ◽  
Primary Progressive ◽  
Syntactic Representation ◽  
Logopenic Aphasia ◽  
Present Tense ◽  
Linguistic Impairment

Taking into account that neuropsychological studies with subjects with language pathologies can contribute to the investigation of the organization of syntactic knowledge, the objective of this work is to investigate the syntactic representation of the perfect aspect based on data from subjects with pathologies that affect their language. More specifically, we aimed to investigate the possible phrases associated with the types of the perfect aspect and the hierarchy among them. This work aims to investigate the syntactic representation of the perfect aspect. Therefore, we sought to verify a possible linguistic impairment of this aspect in individuals diagnosed with Alzheimer's Disease (AD) and Primary Progressive Logopenic Aphasia (LPPA). A double case study was carried out with one patient with AD and another with LPPA. The methodology consisted of applying functionality tests, neuropsychological tests, and linguistic tests. The results indicated that both the AD patient and the LPPA patient present functional decline and cognitive impairment, with the degree of impairment of the first patient being more extensive than that of the second one in both cases. Regarding language, the patient with AD showed impairment with all four types of perfect, present tense, and imperfective aspect, whereas the LPPA patient has shown impairment only in perfect of recent past and present tense. Based on the results we propose the existence of a phrase to perfect of recent past and the dominance of the temporal phrase over the perfect phrases in the syntactic hierarchy.

scholarly journals Logopenic aphasia or Alzheimer's disease: Different phases of the same disease?

2014 ◽  
Vol 8 (3) ◽  
pp. 302-307 ◽  
Author(s):  
Bárbara Costa Beber ◽  
Renata Kochhann ◽  
Bruna Matias da Silva ◽  
Marcia L. F. Chaves
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Diagnosis ◽  
Clinical Case ◽  
Primary Progressive Aphasia ◽  
Clinical Findings ◽  
Initial Symptom ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Logopenic Aphasia

The logopenic variant of Primary Progressive Aphasia, or logopenic aphasia, is a the most recently described variant of Primary Progressive Aphasia and also the least well defined. This variant can present clinical findings that are also common to Alzheimer's disease, given they both share the same cytopathologic findings. This article reports the clinical case of a patient for whom it proved difficult to define a clinical diagnosis, being split between the logopenic variant and Alzheimer's disease at different phases of the disease. Using this case as an example and drawing on the latest evidence from the literature on the logopenic variant, we postulate the hypothesis that this variant may present as an initial symptom of Alzheimer's disease in some atypical cases.

Clinical Characteristic in Primary Progressive Aphasia in Relation to Alzheimer’s Disease Biomarkers

2021 ◽  
pp. 1-13
Author(s):  
Sung Hoon Kang ◽  
Hanna Cho ◽  
Jiho Shin ◽  
Hang-Rai Kim ◽  
Young Noh ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Language Impairment ◽  
Amyloid Β ◽  
Primary Progressive Aphasia ◽  
Cortical Atrophy ◽  
Clinical Feature ◽  
Progressive Aphasia ◽  
Disease Biomarkers ◽  
Primary Progressive

Background: Primary progressive aphasia (PPA) is associated with amyloid-β (Aβ) pathology. However, clinical feature of PPA based on Aβ positivity remains unclear. Objective: We aimed to assess the prevalence of Aβ positivity in patients with PPA and compare the clinical characteristics of patients with Aβ-positive (A+) and Aβ-negative (A–) PPA. Further, we applied Aβ and tau classification system (AT system) in patients with PPA for whom additional information of in vivo tau biomarker was available. Methods: We recruited 110 patients with PPA (41 semantic [svPPA], 27 non-fluent [nfvPPA], 32 logopenic [lvPPA], and 10 unclassified [ucPPA]) who underwent Aβ-PET imaging at multi centers. The extent of language impairment and cortical atrophy were compared between the A+ and A–PPA subgroups using general linear models. Results: The prevalence of Aβ positivity was highest in patients with lvPPA (81.3%), followed by ucPPA (60.0%), nfvPPA (18.5%), and svPPA (9.8%). The A+ PPA subgroup manifested cortical atrophy mainly in the left superior temporal/inferior parietal regions and had lower repetition scores compared to the A–PPA subgroup. Further, we observed that more than 90%(13/14) of the patients with A+ PPA had tau deposition. Conclusion: Our findings will help clinicians understand the patterns of language impairment and cortical atrophy in patients with PPA based on Aβ deposition. Considering that most of the A+ PPA patents are tau positive, understanding the influence of Alzheimer’s disease biomarkers on PPA might provide an opportunity for these patients to participate in clinical trials aimed for treating atypical Alzheimer’s disease.

O2-14-01: HETEROGENEOUS LANGUAGE PROFILES IN PATIENTS WITH PRIMARY PROGRESSIVE APHASIA DUE TO ALZHEIMER'S DISEASE

2014 ◽  
Vol 10 ◽  
pp. P196-P197
Author(s):  
Antoinette M. Keulen ◽  
Eva Louwersheimer ◽  
L.C. Jiskoot ◽  
John C. van Swieten ◽  
Yolande A.L. Pijnenburg
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Language Profiles

Making the Right Connections: Maximizing Lexical Generalization in Lexical Impairments in Primary Progressive Aphasia and Alzheimer's Disease

2021 ◽  
pp. 1-16
Author(s):  
Ashleigh Beales ◽  
Anne Whitworth ◽  
Jade Cartwright ◽  
Peter K. Panegyres ◽  
Robert T. Kane
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family Members ◽  
Primary Progressive Aphasia ◽  
Lexical Retrieval ◽  
Connected Speech ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Word Classes ◽  
The Impact

Purpose Positive intervention effects following lexical retrieval interventions are increasingly reported with people with progressive language impairments; however, generalization of therapy gains are less frequently evident and less well understood. This study sought to explore the impact of specific therapy ingredients on generalization outcomes. Method Twelve participants with progressive lexical retrieval deficits (four each with semantic variant primary progressive aphasia, logopenic variant primary progressive aphasia, and Alzheimer's disease, amnestic presentation) and their family members participated in a 6-week intervention that aimed to increase access to different word classes (nouns, verbs, and adjectives) through a strategic self-cueing approach. Generalization was actively facilitated through strategy practice in connected speech. Repeated baselines of picture naming and connected speech were conducted prior to intervention and repeated immediately post and at 6 weeks following intervention. Results All three diagnostic groups showed significant improvements in naming performance post-intervention for all word classes and for both treated and untreated items, demonstrating consistent treatment effectiveness and generalization at the word level. No changes in the informativeness or efficiency of connected speech were found. Conclusions Despite heterogeneity across participants, widespread evidence of both treatment effects and generalization to untreated items was found for all diagnostic groups and word classes. The consistent within-level generalization across all groups is explored here in relation to optimization of strategy use through incorporation of cognitive scaffolds, strategic practice at the connected speech level, and the inclusion of family members. The absence of across-level generalization to connected speech is also explored. Supplemental Material https://doi.org/10.23641/asha.14219771

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