scholarly journals MODERN METHODS OF ANXIETY ASSESSMENT of RODENTS BY TESTS BASED ON UNCONDITIONal BEHAVIOR MODELS

2018 ◽  
Vol 25 (6) ◽  
pp. 171-176
Author(s):  
A. Kh. Kade ◽  
S. V. Kravchenko ◽  
A. I. Trofimenko ◽  
P. P. Poliakov ◽  
A. S. Lipatova ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Laboratory Animals ◽  
Behavioral Reactions ◽  
Anxiety Management ◽  
Treatment And Prevention ◽  
Anxiety Assessment ◽  
Plus Maze ◽  
Test Light ◽  
Animal Models Of Anxiety ◽  
Behavior Models

Aim.The main aim of this research is to overview some main methods of anxiety assessment of animals by the behavioral tests based on the unconditional models. Animal models of anxiety disorders are actively used for studying their etiology and pathogenesis and for their treatment and prevention. This review describes some basic unconditional methods of anxiety disorders assessment in laboratory animals: open field test, light-dark box test / light-dark exploration box, elevated plus-maze and Suok test. The principles of conducting this test, regulated parameters and their link with anxiety-level are described.Conclusion.A modern researcher possesses different methods of modeling anxiety disorders in rodents. The tendency to an in-depth assessment of the behavioral reactions is noted. The use of the described models allows us to reveal and analyze the anxiolytic activity of new pharmacological drugs and non-pharmacological methods of pathological anxiety management. The most important aspect of performing this research is the correct matching of received data and normal and pathological human physiology features. 

Features of the sensitivity of the central nervous system of the organism of experimental animals to the effects of certain psychotropic drugs and their combinations against the background of chronic alcohol intoxication in a chronopharmacological experiment

2020 ◽  
pp. 56-62
Author(s):  
E.V. Filippova
Keyword(s):  
Alcohol Intoxication ◽  
Laboratory Animals ◽  
Histological Structure ◽  
Chronic Alcohol ◽  
Behavioral Reactions ◽  
Experimental Animals ◽  
Chronic Alcohol Intoxication ◽  
Psychotropic Action ◽  
Adaptive Effect ◽  
The Central Nervous System

In a chronopharmacological experiment, the effect of two drugs with psychotropic action in combinations on the behavior of laboratory animals subjected to chronic alcohol intoxication was examined. Against the background of a deprimating agent, a decrease in the threshold of sensitivity to electrical irritation and the duration of an aggressive reaction was revealed; an increase in these indicators was established with a combination of a deprimating drug with an antioxidant. It has been shown that the antioxidant has a desynchronizing effect on the behavioral reactions of laboratory animals for two days, which indicates a pronounced adaptive effect. In the case of using combinations of a deprimating agent with an antioxidant, a decrease in the destruction of the histological structure of the myocardium against the background of chronic alcoholization was established.

Is There a Science of Psychotherapy?

2018 ◽  
Author(s):  
Jack M. Gorman
Keyword(s):  
Anxiety Disorders ◽  
Life Experience ◽  
Conditioned Fear ◽  
Fear Memory ◽  
Cognitive Behavioral ◽  
Psychoanalytic Psychotherapy ◽  
Laboratory Animals ◽  
Psychiatric Illnesses ◽  
Brain Pathways ◽  
Unconscious Memory

Traditionally, psychotherapists have been reluctant to embrace neuroscience, incorrectly believing that it is solely devoted to finding more drugs for psychiatric illnesses. By thinking of psychotherapy as a type of life experience, however, we see that many aspects of neurobiology are relevant to psychotherapy and strengthen our understanding of how psychotherapy works. One example is studies showing that the same brain pathways involved in the acquisition and extinction of conditioned fear in laboratory animals and in anxiety disorders in humans are also affected by cognitive behavioral psychotherapy. Another example is the similarity of the ability to permanently abolish fear memory by blocking its reconsolidation and the reframing of a previously unconscious memory during psychoanalytic psychotherapy. A neuroscience of psychotherapy is certainly conceivable.

Animal models of anxiety disorders: behavioral and genetic approaches

2011 ◽  
pp. 156-167 ◽  
Author(s):  
Jesse W. Richardson-Jones ◽  
E. David Leonardo ◽  
Rene Hen ◽  
Susanne E. Ahmari
Keyword(s):  
Animal Models ◽  
Anxiety Disorders ◽  
Animal Models Of Anxiety

scholarly journals Ketamine alone or combined with midazolam or dexmedetomidine does not affect anxiety-like behaviours and memory in adult Wistar rats

2016 ◽  
Vol 51 (2) ◽  
pp. 147-159 ◽  
Author(s):  
Ana Magalhães ◽  
Ana Valentim ◽  
Carlos Venâncio ◽  
Mariana Pereira ◽  
Pedro Melo ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Wistar Rats ◽  
Radial Maze ◽  
Emotional Reactivity ◽  
Scientific Data ◽  
Laboratory Animals ◽  
Adult Rats ◽  
Adult Rat ◽  
Plus Maze

Ketamine administration has been associated with controversial behavioural impairments and psychotic episodes. Even though ketamine alone and in combination with midazolam or dexmedetomidine are frequently used in laboratory animals, the side-effects of such protocols are not well known. Therefore, our aim was to evaluate the effects of ketamine alone and in combination with midazolam or dexmedetomidine on emotional reactivity, as well as the effects on learning and memory in adult rats at least 48 h after anaesthesia. The evaluation of the potential influence of 100 mg/kg ketamine administered alone and in combination with midazolam (5 mg/kg), or dexmedetomidine (0.25 mg/kg) on spatial learning and recognition memory was studied in adult Wistar rats using the radial maze as well as object recognition and location tests. The influence of these combinations on emotional reactivity was investigated using the new exploration test and the elevated plus maze. Results showed that ketamine alone or in combination with midazolam or dexmedetomidine affected neither spatial and recognition memory, nor emotional reactivity. These results reinforce the safe clinical use of ketamine and its combinations in rats in a research context since the administration of these anaesthetic combinations did not produce significant changes with regard to spatial and recognition memory or emotional reactivity. Furthermore, these results indicate that the quality of scientific data produced in adult rat neurobehavioural research is not jeopardized by the use of these anaesthetic protocols.

Stresspac: A Controlled Trial of a Self-Help Package for the Anxiety Disorders

1995 ◽  
Vol 23 (2) ◽  
pp. 89-107 ◽  
Author(s):  
Jim White
Keyword(s):  
Anxiety Disorder ◽  
Anxiety Disorders ◽  
Controlled Trial ◽  
Individual Therapy ◽  
Anxiety Management ◽  
Ways Of Coping ◽  
Self Help ◽  
Management Advice ◽  
Post Therapy

In order to test the efficacy of a self-help anxiety management package, sixty-two individuals meeting DSM-III-R criteria for an anxiety disorder were randomly allocated to one of three conditions: Stresspac patients were given a self-help/information package. Advice only patients were offered verbal advice on ways of coping with anxiety. Patients in both conditions were seen on one occasion shortly after referral for assessment and management advice. They were then placed back on the waiting list for a three month period. Patients in the No intervention condition also completed measures during this time. They were not seen until the end of this period when formal assessment took place. All patients were then followed through individual therapy and to 12 month follow-up. Results clearly support the superiority of the Stresspac condition after the waiting period, at post therapy and at follow-up on a range of measures. Possible explanations for the results are discussed.

scholarly journals Research of acute toxicity, allergizing and local-irritative action of the veterinary drug “Yodozol”

2019 ◽  
pp. 54-58
Author(s):  
R. M. Sachuk ◽  
S. V. Zhyhalyuk ◽  
I. M. Lukyanik ◽  
M. S. Mandyhra ◽  
Ya. S. Stravsky ◽  
...  
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Behavioral Responses ◽  
Physiological Parameters ◽  
Laboratory Animals ◽  
Veterinary Drug ◽  
Intragastric Administration ◽  
Toxic Substances ◽  
Treatment And Prevention ◽  
Mucous Membranes

The purpose of the work was to determine, in experiments on rodents, the parameters of acute toxicity, allergenic and locally irritative effects of iodine-containing uterine drug for the treatment and prevention of intrauterine infections of animals. Materials and methods. Preclinical studies of acute toxicity of “Yodosol” containing iodine and potassium iodide were performed on 90 white mice, 30 white outbred rats and 6 rabbits. Clinical, pharmacotoxicological and statistical methods were used. Results of work. It has been found that at intragastric administration in experimental rats and mice, DL50 values exceed 8,000 mg/kg body weight and have no effect on the behavioral responses and physiological parameters of laboratory animals. It has been investigated that “Yodosol” aerosol has no local toxic and irritant effects on the skin and mucous membranes of laboratory animals (rabbits). Conclusions. The use of the drug «Yodosol», in doses above 8,000 mg/kg body weight, does not affect the behavioral responses and physiological parameters of laboratory animals. The drug has no local toxic and irritant effects on the skin and mucous membranes. According to the requirements of SOU 85.2-37-736:2011 and GOST 12.1.007-76, the newly developed drug “Yodosol” belongs to low-toxic substances — 4 toxicity classes

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