Review on Microsponges As a Novel Drug Delivery System

Microsponge can be effectively incorporated into oral delivery of drugs using bio erodible polymer’s especially for colon specific delivery and also use for topical drug delivery system for retention of dosage form on skin and controlled release drug delivery system thus improving patient compliance by proving site specific drug delivery system and prolonging dosage intervals. The microsponge consists of myriad of interconnecting voids within non- collapsible structures with a large porous surface. The size of Micro sponges can be varied usually from 5-300 μm in diameter. The outer surface is typically porous, allowing the sustained flow of substances out of the sphere. Microsponge delivery system (MDS) can provide increased efficacy for topically active agents with enhanced safety, extended product stability, enhanced formulation flexibility , reduced side effects and improved aesthetic properties in an efficient and novel manner In addition these are non-mutagenic, non allergic, and non-toxic . The present review introduces Microsponge technology along with its synthesis, characterization, programmable parameters and release mechanism of MDS