Tumor-associated tissue eosinophilia in oral squamous cell carcinoma – A predictable biological behavior

Objectives: Squamous cell carcinoma of the oral cavity is the most common aggressive epithelial malignant neoplasm. Its biological behavior is influenced by the host immune cells, such as multifaceted eosinophils, associated with wound healing and tissue damage processes. Their presence within a variety of human cancers raises queries about their role. The infiltrations of tumor stroma by eosinophils are believed to play a significant role in progression of the carcinoma and could be either a potential diagnostic tool for stromal invasion or as a prognostic indicator. Its role in cancer still remains unclear since in the literature, there are very few studies showing improved prognosis and few contradictory studies showing poor prognosis. This study was conducted with an aim to compare the tumor-associated tissue eosinophilia in oral squamous cell carcinoma (OSCC) and normal tissue and to correlate the expression in different grades of carcinoma using a special stain that targets eosinophils exclusively and vividly. Materials and Methods: The study includes 30 samples, six normal, and 24 histopathologically diagnosed with OSCC. 5 μ thick sections were made and stained using special stain and examined under high power (×40), ten consecutive microscopic fields were studied. The average numbers of eosinophils were statistically analyzed. Results: Eosinophil count for carcinoma was higher compared to normal mucosa, but the comparison in different grades of cancer did not show much difference. Conclusion: Since eosinophil count was higher in carcinoma, eosinophil infiltration in dysplastic cases should prompt thorough evaluation for invasiveness.

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Rural profile of oral squamous cell carcinoma (OSCC) survival patients attending in tertiary level hospital in Bogura: a hospital based retrospective observational study.

Update Dental College Journal ◽

10.3329/updcj.v10i1.46684 ◽

2020 ◽

Vol 10 (1) ◽

pp. 3-5

Author(s):

Parometa Barma ◽

Ibrahim Khalil ◽

Tanzima Yeasmin

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Malignant Neoplasm ◽

P Value ◽

Oral Epithelium ◽

Tertiary Level ◽

Total Cancer ◽

Grade Ii

Developing country like Bangladesh among 90% of oral malignant neoplasm are arising from squamous layer of oral epithelium which are third leading of this country with severe disfiguration, functiolaesa, psychological impairments and socio-economic hardship. In this study we found the prevalence of OSCC was 6.5% among total cancer patients in the two tertiary level hospitals of Bogura. Male (70%) are affected more than in females (30%). In response to male and female parameter, sex distribution ratio was 2.3:1. The prevalent average age was 55.40 years. About 80% of ulcer site was buccal mucosa then 10 % were lip mucosa. About 80% people were habituated by betel nut, leaf with tobacco chewers. Moreover 46.7% of them were maltreated by quack doctors before. Majority of the patient was in Grade II (56.7%). Correlation between variable in respect of age and cancer grading was explained. According to these study OSCC patients in north bangle region like Bogura was quite high on ( significant p-value ≤ 0.05). Description of oral squamous cell carcinoma on the basis of demographic and clinical profile was the major aim . Most of the cases report with intermediate grade of the disease which often leads to decrease the chance of survival of a patient. So new strategies should be considered to overcome the present situation must be undertaken by oral health programs for the early diagnosis and prevention, build up awareness and management and follow up of oral cancer. Update Dent. Coll. j: 2020; 10 (1): 3-5

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Relationship Between mir15b and Sal-Like Protein 4 and Biological Behavior of Oral Squamous Cell Carcinoma

Journal of Biomaterials and Tissue Engineering ◽

10.1166/jbt.2021.2548 ◽

2021 ◽

Vol 11 (2) ◽

pp. 308-314

Author(s):

Zengbo Wu ◽

Yan Yan ◽

Xianzhuo Chen ◽

Yanling Liu ◽

Dinggen Chen

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Normal Mucosa ◽

Clinicopathological Features ◽

Biological Behavior ◽

Control Group ◽

Tumor Tissues ◽

Proliferation And Invasion

miR15b and SALL4 are involved in a variety of tumor progression. The roles of miR15b and SALL4 in oral squamous cell carcinoma (OSCC) remains unclear. The tumors and normal mucosa of OSCC patients were collected to detect miR15b and SALL4 level by Real-time PCR and analyze their correlation with OSCC clinicopathological features. Oral cancer Tca8113 cells were separated into control group; miR15b mimics group and miR15b inhibitor group followed by analysis of SALL4 expression, cell survival by MTT assay; cell invasion by Transwell chamber assay, as well as expression of N-cadherin and Vimentin and correlated with TNM stage, tumor volume and metastasis, and positively with differentiation TGF-β by Western blot. miR15b expression was decreased and SALL4 expression was increased in OSCC tumor tissues. miR15b was negatively degree (P < 0.05), whereas, opposite correlation of SALL4 with the above parameters was found (P < 0.05). miR15b and SALL4 were negatively correlated. MiR15b mimics significantly up-regulated MiR15b, decreased SALL4 expression, inhibited Tca8113 cell proliferation and invasion, as well as reduced N-cadherin, Vimentin and TGF-βexpression (P < 0.05). Opposite results were found in MiR15b inhibitor group. MiR15b expression is decreased and SALL 4 is increased in OSCC tumor tissues. MiR15b and SALL4 is closely related to OSCC clinicopathological features. MiR15b regulates the expression of EMT-related genes and TGF-β, thereby altering the proliferation and invasion of OSCC cells.

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Tumour associated tissue eosinophilia as a predictor of locoregional recurrence in oral squamous cell carcinoma

Journal of Clinical and Experimental Dentistry ◽

10.4317/jced.51610 ◽

2015 ◽

pp. e1-e6 ◽

Cited By ~ 3

Author(s):

N. Rakesh ◽

Y. Devi ◽

K. Majumdar ◽

SS. Reddy ◽

K. Agarwal

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Locoregional Recurrence ◽

Tissue Eosinophilia

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Feulgen stain as a special stain for mitotic figures and apoptotic bodies in oral squamous cell carcinoma

SRM Journal of Research in Dental Sciences ◽

10.4103/srmjrds.srmjrds_49_18 ◽

2018 ◽

Vol 9 (4) ◽

pp. 164

Author(s):

Sankari Radhakrishnan ◽

Ramesh Venkatapathy ◽

PD Balamurali ◽

KarthikShree V Prashad ◽

B Premalatha ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Apoptotic Bodies ◽

Special Stain ◽

Mitotic Figures

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Tumor associated tissue eosinophilia in oral squamous cell carcinoma: A systematic review and meta-analysis

Journal of Oral Biology and Craniofacial Research ◽

10.1016/j.jobcr.2020.11.012 ◽

2021 ◽

Vol 11 (1) ◽

pp. 33-39

Author(s):

Nilookumari Choudhary ◽

Gargi S. Sarode ◽

Monal Yuwanati ◽

Nikunj Maniyar ◽

Sachin C. Sarode ◽

...

Keyword(s):

Systematic Review ◽

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Meta Analysis ◽

Tissue Eosinophilia

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An Atypical Case of Oral Squamous Cell Carcinoma of Mandibular Alveolus

Case Reports in Dentistry ◽

10.1155/2019/2521685 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6

Author(s):

Seba Abraham ◽

Bhagyalekshmi Mallika ◽

Arunima Reshma ◽

ReejaMol Mohammed Kassim

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Malignant Neoplasm ◽

Squamous Cell Carcinomas ◽

Common Type ◽

Dental Practice ◽

Prompt Treatment ◽

Precise Knowledge

Oral squamous cell carcinoma is the most common type of oral malignant neoplasm. As per literature, squamous cell carcinomas of the alveolar ridge account for 9% of all the oral carcinomas. The oral squamous cell carcinoma shares clinical similarity with various forms of inflammatory gingival lesions and is often misdiagnosed in our routine dental practice. The dentist should have precise knowledge regarding the clinical manifestation of this deadly disease as early diagnosis and prompt treatment can reduce morbidity and mortality of the disease.

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