Influence undifferentiated connective tissue dysplasia on sta the macular region in children with progressive myopia

2020 ◽  
pp. 26-27
Author(s):  
V.V. Li ◽  
◽  
O.V. Kolenko ◽  
V.V. Egorov ◽  
G.P. Smoliakova ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Dysplasia ◽  
Progressive Myopia

Актуальность. Миопия у детей относится к числу самых распространенных причин снижения зрения. Согласно современным представлениям, в происхождении и прогрессировании миопии ведущую роль играют нарушения биомеханических свойств склеральной капсулы глаза, которые ассоциированы с недифференцированной дисплазией соединительной ткани (НДСТ). Известно, что большую роль в сосудисто-трофическом обеспечении внутренних слоев склеры играет хориоидея, где сосредоточено более 80% циркулирующей в глазу крови. Поэтому отклонения в хориоидальном кровотоке будут способствовать снижению трофических и биомеханических свойств склеры и, следовательно, созданию условий для увеличения аксиальных размеров глаза и прогрессирования миопии. Цель. Изучить влияние недифференцированной дисплазии соединительной ткани на толщину сосудистой оболочки. Материал и методы. Объект исследования – 120 детей (240 глаз) с прогрессирующей миопией средней и высокой степени осевого типа в возрасте 12–15 лет. Все дети были разделены на 2 группы: основную – 50 чел. (100 глаз) с умеренной и выраженной степенью НДСТ и контрольную – 50 чел. (100 глаз) без фенотипических признаков НДСТ. Специальное офтальмологическое обследование включало оптическую когерентную томографию макулярной зоны (RTVue 100, Optovue, США) – режим увеличения глубины для измерения толщины хориоидеи (ТХ) по протоколу Cross Line в области фовеа и в 1000 мкм от нее в носовую и височную стороны. По полученным данным рассчитывали среднюю ТХ в макуле в мкм. Вариантом нормы являлась ТХ в макуле 10 практически здоровых детей аналогичного возраста с эмметропией. Результаты. После обработки материалов были получены следующие данные: ТХ в макулярной области в основной группе составила 270,1±15,3 мкм, в контрольной группе – 306,3±11,5 мкм, а в группе без патологии рефракции – 325,5±7,6 мкм. Анализ полученных результатов показал статистически значимые межгрупповые различия (p <0,05). Выводы. Установлено, что при наличии НДСТ снижается показатель ТХ в макулярной области, что создает условия для снижения хориоидального кровотока и роста переднезадней оси глаза.

scholarly journals Assessment of cerebral blood flow in children with myopia in combination with undifferentiated connective tissue dysplasia

2021 ◽  
Vol 9 (2) ◽  
pp. 10-13
Author(s):  
T.V. Frolova
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Connective Tissue ◽  
Clinical Signs ◽  
Joint Hypermobility ◽  
Visual Analyzer ◽  
Elastic Parameters ◽  
Beighton Score ◽  
Connective Tissue Dysplasia ◽  
Progressive Myopia

Background. In practice, patients with numerous undifferentiated forms of connective tissue dysplasia are more common. With regard to the combination of myopia and undifferentiated connective tissue dysplasia, one of the links in the mechanism of origin of this refractive anomaly is decreased thickness of the sclera and a change in its elastic parameters. Myopia in children often occurs against the background of impaired blood supply to the visual analyzer associated with circulatory pathology in the vertebral vessels. The purpose was to evaluate cerebral blood flow in patients with myopia in combination with undifferentiated connective tissue dysplasia. Materials and methods. The study involved 86 children (170 eyes) diagnosed with progressive myopia. All patients were consulted by related specialists to detect undifferentiated connective tissue dysplasia and underwent a complete ophthalmological exa-mination. The diagnostic coefficient of expression of phenotypic and clinical signs of undifferentiated connective tissue dysplasia was also determined using the expert table of T. Kadurina. Results. Phenotypic and clinical signs of undifferentiated connective tissue dysplasia were noted in 41 (100 %) cases when evaluating according to the criteria of T. Mil-kovskaya-Dimitrova and T. Kadurina, and in 34 (83.0 %) children du-ring screening for joint hypermobility on Beighton score. As for increased axial length of the eye in the examined patients with myopia and undifferentiated connective tissue dysplasia, it was noted that an increase had a direct correlation with the severity of undifferentiated connective tissue dysplasia, with the greatest correlation obtained in children with pronounced phenotypic manifestations in the musculoskeletal system (correlation coefficient was 0.83). Chemical regulation of carotid artery tone (respiratory failure test) is altered in the vast majority of patients with myopia. Conclusions. All children with progressive myopia are re-commended to be examined by related specialists to identify undif-ferentiated connective tissue dysplasia and hemodynamic disorders. Only a comprehensive approach to this refractive anomaly can be effective in combating its progression.

Features of choroidal blood flow and their influence on formation of peripheral retinal degenerations in school-age children with undifferentiated connective tissue dysplasia

2021 ◽  
pp. 141-144
Author(s):  
V.V. Li ◽  
Keyword(s):  
Connective Tissue ◽  
Choroidal Thickness ◽  
School Age Children ◽  
Comparative Characteristic ◽  
Frequency Of Occurrence ◽  
School Age ◽  
Phenotypic Characters ◽  
Retinal Degenerations ◽  
Connective Tissue Dysplasia ◽  
Progressive Myopia

Purpose. To study choroidal thickness (CT) and assess its effect on frequency of occurrence dangerous types of peripheral retinal degenerations (PRD) in school-age children with myopia associated with undifferentiated connective tissue dysplasia (UCTD). Material and methods. The object of study was 62 children (124 eyes) aged 10–15 years (mean age 12.3±0.8 years) with progressive myopia associated with moderate (48 people, 77.4%) and pronounced (14 people, 22.6%) degree of UCTD. Special ophthalmologic examination included macular imaging by optical coherence tomography (RTVue 100, «Optovue», USA) to measure CT. Diagnostic criteria by T.M. Milkovskaya-Dimitrova et al (1987) were used to identify phenotypic characters of UCTD. Results. Comparative characteristic of CT in macula showed high (p <0.05) relationship between the blood-filled of choroidal vessels and degree of UCTD. Analysis frequency of occurrence of PRD depending on CT demonstrated that against the background accumulation of phenotypic characters of UCTD increase in frequency of occurrence of PRD was observed. Statistical analysis confirmed presence of significant negative correlation between decrease CT and increase in incidence of prognostically dangerous forms of PRD. Conclusion. It was found that in school-age children with myopia with increase degree of UCTD, CT decreases. With choroidal thinning in children with myopia associated with UCTD, the frequency of occurrence dangerous forms of PRD increases. The research results are of clinical importance for the development of rational approaches to clinical examination and treatment children with school myopia with clinical signs of UCTD. Key words: progressive myopia, undifferentiated connective tissue dysplasia, choroidal thickness, peripheral retinal degeneration, rhegmatogenous retinal detachment.

Metabolic therapy and its role in the complex treatment of connective tissue dysplasia in Pediatric Nephrology

2016 ◽  
Vol 73 (1) ◽  
pp. 131-136 ◽  
Author(s):  
S.L. Nyan'kovskyi ◽  
◽  
O.O. Dobrik ◽  
M.Yu. Іs'kiv ◽  
◽  
...  
Keyword(s):  
Connective Tissue ◽  
Pediatric Nephrology ◽  
Complex Treatment ◽  
Metabolic Therapy ◽  
Connective Tissue Dysplasia

Features of the course of pregnancy and childbirth in women with syndrome of undifferentiated connective tissue dysplasia

2018 ◽  
Vol 16 (6) ◽  
pp. 39-44 ◽  
Author(s):  
T. L. Smirnova ◽  
◽  
L. I. Gerasimova ◽  
A. E. Sidorov ◽  
V. V. Chernyshov ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Pregnancy And Childbirth ◽  
Connective Tissue Dysplasia

Bone mineral density and bone turnover markers in women with connective tissue dysplasia

2019 ◽  
Vol 17 (4) ◽  
pp. 102-106
Author(s):  
M. Yu. Smetanin ◽  
◽  
S. Yu. Nurgalieva ◽  
N. Yu. Kononova ◽  
L. T. Pimenov ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Connective Tissue ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Mineral Density ◽  
Connective Tissue Dysplasia ◽  
Turnover Markers

Cephalometric features of connective tissue dysplasia manifestation in children and adolescents

2020 ◽  
Vol 20 (3) ◽  
pp. 174-183 ◽  
Author(s):  
B. N. Davydov ◽  
D. A. Domenyuk ◽  
S. V. Dmitrienko ◽  
T. A. Kondratyeva ◽  
Yu. S. Harutyunyan
Keyword(s):  
Connective Tissue ◽  
Morphological Features ◽  
Short Branch ◽  
Lower Jaw ◽  
Carious Lesions ◽  
High Prevalence ◽  
Care Facilities ◽  
The Face ◽  
Connective Tissue Dysplasia ◽  
Brain Parts

Relevance. The high prevalence of dysplastic disorders involving connective tissue, and its negative effecton the development of dentoalveolar anomalies, carious and non-carious lesions of the teeth, periodontopathy, temporomandibular joint issues in the child population, lay the basis for improving diagnostics algorithms. Enhancing the already available standards is of greatest importance for children at the initial stages of diagnostics when evaluating the external signs of dysplastic disorders.Purpose – improving diagnostics algorithms for connective tissue dysplasia (CTD) in children in primary dental care facilities based on the evaluation of external phenotype signs and maxillofacial morphological features.Materials and methods. Depending on the external phenotype manifestations severity, as well as on laboratory, clinical and instrumental signs, the 92 children with CTD were divided into groups with mild, moderate and severe degrees of undifferentiated dysplasia. Gnathometric and biometric examinations of the maxillofacial area were performed through traditional methods, whereas the diagnosis was set following the generally accepted classifications. The diagnosis confirmation implied evaluation through cone beam computed imaging.Results. The nature and the intensity of morphofunctional disorders in the craniofacial structures (“small” stigmas) depend on the severity of connective tissue dysplastic disorders.Conclusions. The change direction vector in the facial and brain parts of cranium in children with CTD is aimed at increasing hypoplastic tendencies and dolichocephalia, proof to that being the following constitutional and morphological features: the prevalence of the vertical type of face skeleton growth over the horizontal and neutral ones; a convex face profile with a disproportionate general heights of the face skeleton; reduction of latitudinal with an increase in altitude facial parameters; a narrow short branch of the lower jaw; the upper jaw displaced downwards and forward; a decrease in the size of the apical basis of the lower dentition, the lower jaw body, as well as the height and width of the lower jaw branches. 

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