Matrix metalloproteinase-1, -8, -9 and the risk of cardiovascular complications in patients with CHD before and after myocardial revascularization

2017 ◽  
pp. 37-45
Author(s):  
Е.В. Шкорик ◽  
Е.В. Маркелова ◽  
А.А. Силаев ◽  
Б.И. Гельцер ◽  
А.А. Семенихин ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Artery Bypass ◽  
Myocardial Revascularization ◽  
Cardiovascular Complications ◽  
Group Differences ◽  
Matrix Metalloproteinase 1 ◽  
Before And After ◽  
Detection Of Biomarkers

До сих пор существует потребность в поиске биомаркеров для раннего прогнозирования и диагностики сердечно-сосудистых осложнений (ССО) у пациентов с ИБС. Цель - определение роли матриксных металлопротеиназ (ММП-1, 8, 9) в риске развития CCО у пациентов с ИБС до и после аортокоронарного шунтирования (АКШ). Методика. В исследование включены 75 больных с ИБС до и после реваскуляризации миокарда методом АКШ, из них 40 мужчин и 35 женщин в возрасте от 45 до 74 лет. Пациенты были разделены на 2 группы: I группа - 25 больных с зарегистрированными ССО после АКШ (острый инфаркт миокарда, ишемический инсульт, тромбоэмболия легочных ветвей); II группа - 50 больных с ИБС без осложнений после реваскуляризации миокарда. Забор крови осуществлялся за сутки до операции, в 1-е, 3-и и 10-е сутки после АКШ. Определение уровня ММП-1, -8, -9 проводилось в сыворотке крови методом твердофазного ИФА, с использованием специфических реактивов «RD Diagnostics Inc.», USA. Результаты выражали в нг/мл. Данные представляли в виде медианы и двух квартилей (Me, Q, Q). Внутри и межгрупповые различия оценивали с помощью критерия Манна-Уитни, коэффициента корреляции Спирмена и критерия c в рамках прикладной программы SPSS №16. Статистически значимыми считали различия между показателями при отклонении нулевой гипотезы и уровне значимости p<0,05. Результаты. Выявлено статистически значимое повышение концентрации ММП-1 и ММП-8 у больных в I группе. Не выявлено значимой динамики ММП-9 у пациентов после реваскуляризации миокарда. Заключение. Полученные результаты свидетельствуют, что уровень ММП-1 2,5 нг/мл и более у пациентов с ИБС является диагностическим критерием риска возникновения ТЭ осложнений. Не установлено связи между повышенным содержанием ММП-8 и наличием осложнений у пациентов после операции. Не выявлено значимой динамики ММП-9 у пациентов после реваскуляризации миокарда. There is still a great need for detection of biomarkers for early prediction and diagnosis of cardiovascular complications (CVC) in patients with CHD. Objective: To determine the role of MMP-1, 8, 9 in the risk of CCO in patients with CHD before and after coronary artery bypass grafting (CABG). Methods. The study included 75 patients with coronary heart disease before and after myocardial revascularization by CABG, including 40 men and 35 women aged from 45 to 74 years. Patients were divided into two groups: I group - 25 patients with CVC registered after CABG (acute myocardial infarction, ischemic stroke, pulmonary thromboembolism Branch); II group - 50 patients with coronary heart disease without complications after myocardial revascularization. Blood sampling was performed the day before surgery, on the 1st, 3rd and 10th days after CABG. Determining the level of MMP-1, 8, 9 in the serum was performed by ELISA using reagents specific «RD Diagnostics Inc.», USA. Results are expressed in ng/ml. Data are presented as medians and quartiles of two (Me, Q25, Q75). Within and between-group differences were evaluated using the Mann - Whitney, Spearman correlation coefficient and c

CURRENT ASPECTS OF CORONARY HEART DISEASE DIAGNOSIS AND TREATMENT

2020 ◽  
pp. 5-10
Author(s):  
O. M. Korzh
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Drug Therapy ◽  
Coronary Arteries ◽  
Artery Bypass ◽  
Myocardial Revascularization ◽  
Disease Diagnosis ◽  
Percutaneous Coronary Angioplasty ◽  
Mortality And Morbidity ◽  
Intravascular Thrombosis

Among the cardiovascular diseases associated with atherosclerosis, chronic coronary heart disease, including angina, is the most common form. It is the myocardium lesion that develops as a result of an imbalance between the coronary circulation and metabolic needs of heart muscle. The presence of angina symptoms often indicates a pronounced narrowing of one or more coronary arteries, but also occurs in non−obstructive arterial impairment and even in normal coronary arteries. Factors of functional damage to the coronary arteries are spasm, temporary platelet aggregation and intravascular thrombosis. Today there are opportunities not only to use the therapy with proven effectiveness, aimed at reducing the risk of complications, including fatal, but also to treat angina (ischemia), which improves the patient's life quality. The drug protocol includes the ones with a proven positive effect on this disease prognosis, which are mandatory if there are no direct contraindications to use, as well as a large group of antianginal or anti−ischemic drugs. The choice of a particular drug or its combinations with other drugs is carried out in accordance with generally accepted recommendations: taking into account the individual approach, the severity of angina, hemodynamic parameters (heart rate and blood pressure, presence of comorbid conditions). If drug therapy is ineffective, the option of coronary myocardial revascularization (percutaneous coronary angioplasty or coronary artery bypass grafting) is considered. Due to the high mortality and morbidity rates of coronary heart disease worldwide, one of the priorities of practical health care is the prevention of diseases caused by atherosclerosis. Key words: coronary heart disease, angina, family physician, prognosis, drug therapy.

scholarly journals Lipid Peroxidation Product and Glutathione Levels in Patients with Coronary Heart Disease Before and After Surgery

2015 ◽  
Vol 4 (2) ◽  
pp. 78-82
Author(s):  
Rahman Khansha ◽  
Behnoosh Miladpour ◽  
Zohreh Mostafavi-Pour ◽  
Fatemeh Zal
Keyword(s):  
Oxidative Stress ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Ischemia Reperfusion ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Lipid Peroxidation Product ◽  
Cabg Surgery ◽  
Significant Difference ◽  
Before And After

Background: It has been reported that ischemia-reperfusion is associated with augmentation of oxidative stress and its specific and sensitive markers. Oxidative stress may cause atrial fibrillation (AF) which is a common consequence after cardiac surgery. Dietary supplementation with antioxidants might lower the incidence of AF following coronary artery bypass graft (CABG) surgery. Materials and Methods: Fifty patients with coronary heart disease (CHD) referred to Namazi and Faghihi Hospitals in Shiraz, undergone elective CABG, were enrolled in this study. For evaluation of oxidative stress, whole blood was taken before and 24 hours after surgery and malondialdehyde (MDA) as an oxidative marker and glutathione (GSH) as an antioxidant marker were measured. Results: Results showed a significant difference between the mean concentration of GSH before and after CABG surgery (P <0.05); however, the difference in plasma MDA levels before and after CABG was insignificant. Conclusion: CABG surgery results in oxidative stress and reduces GSH 24h after surgery and administration of antioxidants may attenuate post-operative oxidative stress. [GMJ.2015;4(2):78-82]

scholarly journals Coagulation system reaction to blood loss volume as a result of coronary artery bypass surgery in aspirin-resistant patients with coronary heart disease and arterial hypertension

2011 ◽  
Vol 17 (5) ◽  
pp. 474-477
Author(s):  
U. Mukhamedova ◽  
M. A. Karpenko ◽  
V. N. Solncev
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Blood Loss ◽  
Arterial Hypertension ◽  
Bypass Surgery ◽  
Artery Bypass ◽  
Myocardial Revascularization ◽  
Aspirin Resistance ◽  
Coagulation System ◽  
Blood Loss Volume

Objective. To assess the coagulation system reaction and blood loss volume depending on aspirin resistance in hypertensive patients with coronary heart disease who underwent bypass surgery. Design and methods. A total of 66 patients with arterial hypertension and coronary heart disease (angina pectoris of III-IV functional class according to Canadian classification) who underwent myocardial revascularization using extracorporeal circulation were examined. All patients were divided into two groups depending on aspirin resistance phenomenon. 22 aspirin-resistant patients formed the first group, the other group consisted of 44 aspirin-sensitive patients. The patients were 49 to 68 year old, and there were 27 women and 39 men. During intraoperative and postoperative periods blood loss was measured in all subjects. Results. We showed that 22 out of 66 patients were aspirin-resistant. No relationship between blood loss volume during intraoperative and postoperative periods and aspirin resistance was observed. All hemostatic system indices regardless of aspirin resistance phenomenon changed equally in both groups.

scholarly journals Resistance to Acetylsalicylic Acid in Patients with Coronary Heart Disease Is the Result of Metabolic Activity of Platelets

2020 ◽  
Vol 13 (8) ◽  
pp. 178
Author(s):  
Yuriy I. Grinshtein ◽  
Andrei A. Savchenko ◽  
Aleksandra A. Kosinova ◽  
Maxim D. Goncharov
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Platelet Aggregation ◽  
Acetylsalicylic Acid ◽  
Artery Bypass ◽  
Postoperative Treatment ◽  
Oxygen Species ◽  
Before And After ◽  
Aggregation Activity ◽  
Cabg Patients

Sensitivity to acetylsalicylic acid (ASA) is important in the treatment of patients with coronary heart disease (CHD) after coronary artery bypass grafting (CABG). Patients were divided into ASA sensitive (sASA) and ASA resistant (rASA) by the activity of platelet aggregation induced arachidonic acid (ARA) together with ASA. Induced platelet aggregation activity was studied in sASA and rASA patients with CHD before and after CABG. The level of synthesis of primary and secondary reactive oxygen species (ROS) by platelets was determined using chemiluminescent analysis. The activity of NAD- and NADP-dependent dehydrogenases in platelets was determined by the bioluminescent method. It was found that the aggregation activity of platelets depended on the sensitivity of CHD patients to ASA and decreased during postoperative ASA therapy. The most pronounced differences in metabolic parameters of platelets in sASA and rASA patients were detected by Nox2 activity. The synthesis of secondary ROS by platelets of CHD patients did not depend on the sensitivity of patients to ASA but increased during postoperative treatment with ASA. The activity of NAD(P)-dependent dehydrogenases in platelets did not differ in sASA and rASA patients with CHD.

Predictor significance of β2-microglobulinuria in determining the risk of cardiovascular complications in patients with chronic ischemic heart disease

2021 ◽  
Vol 25 (6) ◽  
pp. 49-55
Author(s):  
E. S. Levitskaya ◽  
M. M. Batiushin ◽  
A. V. Khripun
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Ischemic Heart Disease ◽  
Unstable Angina ◽  
Myocardial Revascularization ◽  
Cardiovascular Complications ◽  
Ischemic Heart ◽  
Chronic Ischemic Heart Disease

BACKGROUND. The relevance of identifying new biomarkers of the cardio-renal syndrome in patients with coronary heart disease is beyond doubt. It is promising to study the indicators of tubular dysfunctions as predictors of the risk of cardiovascular complications in patients without primary kidney pathology.THE AIM. Analysis of the effect of β2-microglobulinuria on the prognosis of cardiovascular complications in patients with chronic ischemic heart disease in the long-term period after myocardial revascularization.PATIENTS AND METHODS. The study included 90 patients with coronary artery disease and indications for myocardial revascularization. Coronary bypass surgery was performed in 64 people, coronary artery stenting - in 26. Clinical and anamnestic data were collected in all patients, standard laboratory and instrumental diagnostics were performed. In addition, the level of β2-microglobulin (β2-MG) in the first morning portion of urine was determined at different study dates. The endpoint was considered to be the presence of acute forms of coronary heart disease - myocardial infarction and unstable angina. Survival after 5.8 ±0.1 years after myocardial revascularization was 69 %.RESULTS. A positive linear relationship of weak strength was established between the level of diastolic blood pressure (DBP) and β2-MG of urine obtained before myocardial revascularization (r = 0.28, p = 0.03). Moreover, the Kaplan-Meyer survival analysis showed the effect of an increase in β2-MG of urine over 0.2 ng/ml on the risk of AMI in the long-term period after myocardial revascularization (p = 0.025). It was found that an increase in the concentration of β2-MG in urine determined before myocardial revascularization is a statistically significant risk factor for the development of unstable angina in the long-term period after RM (χ2-criterion = 7.17, p = 0.007).CONCLUSION. It has been shown that an increase in the concentration of β2-MG in urine, reflecting the presence of tubular dysfunctions, can be considered as a predictor of an unfavorable cardiovascular prognosis in patients in the long-term period after myocardial revascularization.

scholarly journals Selection of the transplant for myocardial revascularization

2018 ◽  
Vol 177 (5) ◽  
pp. 96-99
Author(s):  
G. G. Khubulava ◽  
A. S. Nemkov ◽  
V. V. Komok ◽  
Yi. Chzan
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Clinical Practice ◽  
Coronary Artery ◽  
Surgical Treatment ◽  
Internal Thoracic Artery ◽  
Artery Bypass ◽  
Myocardial Revascularization ◽  
Bypass Grafting ◽  
Selection Of

Surgical treatment of coronary heart disease was introduced into clinical practice more than 50 years ago. Only one intervention – the use of left internal thoracic artery for bypass grafting of the anterior interventricular artery – Kolovos’s operation– remains practically unchangeable version of execution as a standard for coronary artery bypass grafting. This review summarizes the half-century use of internal thoracic arteries, autoveins, radiate arteries as conduits for coronary arteries on the basis of the randomized studies and meta-analyzes published by 2018.

scholarly journals Analysis of circulating miRNA levels in coronary heart disease patients with varying degrees of cardiovascular complications risk. correlations with the MSCT-CA data

2020 ◽  
Vol 75 (4) ◽  
pp. 283-291
Author(s):  
Andrey N. Rozhkov ◽  
Dmitriy Yu. Shchekochikhin ◽  
Natalia М. Baulina ◽  
Natalia A. Matveeva ◽  
Olga O. Favorova ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Complications ◽  
Demographic Characteristics ◽  
Atherosclerotic Plaques ◽  
Circulating Microrna ◽  
Circulating Mirnas ◽  
Circulating Micrornas ◽  
Estimated Risk

Rationale. Cardiovascular diseases remain the leading cause of human death in the world. Studying the role of regulatory non-coding RNAs, which include short single-stranded miRNA molecules, allows a more detailed understanding of the pathological processes underlying the progression of atherosclerosis. Objective to compare the levels of circulating miRNAs in patients with coronary heart disease, confirmed by multislice computed tomography-coronarography (MSCT-CA), with risks of cardiovascular complications and clinical and demographic characteristics. To compare the profiles of circulating miRNAs in groups of patients with stable and unstable atherosclerotic plaques. Methods. MicroRNA levels in the plasma of peripheral blood of patients with coronary heart disease were determined using the miScript miRNA PCR Array MIHS-105Z kit (Qiagen). The significance of differences in miRNA levels between the compared groups was determined using the MannWhitney U-test. The correlations of the levels of circulating miRNAs with clinical and demographic parameters were evaluated using the Spearman correlation coefficient. Risk assessment of cardiovascular complications in these patients was carried out using validated scales (ACC/AHA, Framinghm, SCORE, MESA). Atherosclerotic plaque stability was evaluated using MSCT-CA. Results. The study showed a significant (p 0.05) decrease in miR-16, miR-211, miR-195 miRNA levels in the plasma of patients with coronary heart disease, which correlated with an increase in cardiac vascular risk (CVR) according to ACC/AHA, Framingham and MESA. When comparing groups of patients with stable and unstable atherosclerotic plaques, the latter revealed an increase in the level of let-7b-5p circulating microRNA (p 0.05). Conclusion. Significant associations of the three studied microRNAs with the estimated risk of CVR were identified. It is important to find circulating let-7b-5p in a group of patients with unstable atherosclerotic plaques. Correlations were established between the levels of circulating microRNAs and clinical and demographic characteristics of patients. The study shows the involvement of some microRNAs in the regulation of atherosclerosis.

scholarly journals Modern strategies for the treatment of psychoemotional stress in patients with heart coronary disease after myocardial revascularization.

2019 ◽  
Vol 40 (1) ◽  
pp. 25-30
Author(s):  
B. M. Holdovskyy ◽  
I. V. Filimonova, ◽  
S. O. Potalov ◽  
K. V. Serikov ◽  
D. V. Lelyuk ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Ischemic Heart Disease ◽  
Depressive Disorders ◽  
Myocardial Revascularization ◽  
Ischemic Heart ◽  
Postinfarction Cardiosclerosis ◽  
Significant Difference ◽  
Before And After

Coronary heart disease in many countries of the world, including in Ukraine, causes high rates of morbidity, disability and mortality. The study of factors affecting the occurrence, course, prognosis and effectiveness of drug therapy for coronary artery disease is important and relevant. One of such factors is the psychological disorders of the anxiety-depressive spectrum, which often occur in patients with myocardial infarction and after coronary artery bypass grafting; therefore, such patients should be carefully examined for affective disorders and receive appropriate drug therapy.Purpose of the study. Improvement of diagnosis and optimization of patients treatment with ischemic heart disease with concomitant anxiety-depressive disorders after myocardial revascularization.Material and methods. The results of the study are based on survey data and dynamic observation of 95 patients with coronary heart disease, postinfarction cardiosclerosis after myocardial revascularization. The patients underwent examination during the initial examination and after 12 weeks.Results of the study and their discussion.In the study of the psychoemotional state in the patients examined after the treatment, a significant decrease in anxiety manifestations was revealed by 36,4% against the group without fluvoxamine, where there was no significant difference before and after treatment. The manifestations of depressive disorder in the fluvoxamine group significantly decreased after treatment by 45,8 (HADS) and by 47,0% (Beck), in contrast to the group without fluvoxamine, where there was no significant difference before and after treatment.Conclusions. Thus, it has been proved that with the addition of fluvoxamine to combined therapy for patients with ischemic heart disease, postinfarction cardiosclerosis after revascularization of the myocardium shows a more pronounced decrease in the manifestations of anxiety-depressive disorder. Keywords:anxiety-depressive disorders, ischemic heart disease, revascularization of myocardium, antidepressants.

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