Why still doing salvage hysterectomy following concomitant chemoradiation and brachytherapy in locally advanced cervical cancer in 2016?

2016 ◽  
Author(s):  
Sébastien Gouy
Keyword(s):  
Cervical Cancer ◽  
Locally Advanced ◽  
Advanced Cervical Cancer ◽  
Locally Advanced Cervical Cancer ◽  
Concomitant Chemoradiation

scholarly journals Treatment Response of PlatinumBased Chemoradiation on Locally Advanced Cervical Cancer

2016 ◽  
Author(s):  
Oni Khonsa ◽  
Sigit Purbadi ◽  
Nana Supriana ◽  
Bambang Sutrisna
Keyword(s):  
Cervical Cancer ◽  
Treatment Response ◽  
Gynecologic Oncology ◽  
Locally Advanced ◽  
Advanced Cervical Cancer ◽  
Historical Cohort ◽  
Locally Advanced Cervical Cancer ◽  
Significant Difference ◽  
Concomitant Chemoradiation ◽  
Weekly Cisplatin

Objective: To evaluate the efficacy (treatment response), toxicity, and overall survival of concomitant chemoradiation (CRT) with three-weekly cisplatin-ifosfamide compared to CRT with weekly cisplatin in advanced stage cervical cancers (stage IIB-IIIB). Method: This is a historical cohort between 32 patients receiving CRT with three-weekly cisplatin and ifosfamide and 29 patients receiving weekly cisplatin in Gynecologic Oncology division outpatient clinic and ward, Dr. Cipto Mangunkusumo Hospital. Results: There was no significant difference in treatment response, overall and disease-free survival. There was more gastrointestinal toxicity in the cisplatin-ifosfamide arm compared to the other arm (p=0.014), but other toxicity effects were not different. Conclusion: Platinum based-chemoradiation has the same efficacy in terms of treatment response for locally advanced cervical cancer. [Indones J Obstet Gynecol 2015; 3-4: 212-221] Keywords: cisplatin, concomitant chemoradiation, ifosfamide, locally advance stage cervical cancer

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