Impact of a personalized surgical therapy program for advanced high grade serous ovarian cancer on surgical outcomes

2016 ◽  
Author(s):  
Shannon Westin
Keyword(s):  
Ovarian Cancer ◽  
Surgical Therapy ◽  
Surgical Outcomes ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Therapy Program

scholarly journals Differential DNA methylation in high-grade serous ovarian cancer (HGSOC) is associated with tumor behavior

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Henry D. Reyes ◽  
Eric J. Devor ◽  
Akshaya Warrier ◽  
Andreea M. Newtson ◽  
Jordan Mattson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ovarian Cancer ◽  
Dna Methylation ◽  
Surgical Outcomes ◽  
Methylation Status ◽  
Hippo Signaling ◽  
Gene Promoters ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Differentially Methylated Genes

AbstractThe epigenome offers an additional facet of cancer that can help categorize patients into those at risk of disease, recurrence, or treatment failure. We conducted a retrospective, nested, case-control study of advanced and recurrent high-grade serous ovarian cancer (HGSOC) patients in which we assessed epigenome-wide association using Illumina methylationEPIC arrays to characterize DNA methylation status and RNAseq to evaluate gene expression. Comparing HGSOC tumors with normal fallopian tube tissues we observe global hypomethylation but with skewing towards hypermethylation when interrogating gene promoters. In total, 5,852 gene interrogating probes revealed significantly different methylation. Within HGSOC, 57 probes highlighting 17 genes displayed significant differential DNA methylation between primary and recurrent disease. Between optimal vs suboptimal surgical outcomes 99 probes displayed significantly different methylation but only 29 genes showed an inverse correlation between methylation status and gene expression. Overall, differentially methylated genes point to several pathways including RAS as well as hippo signaling in normal vs primary HGSOC; valine, leucine, and isoleucine degradation and endocytosis in primary vs recurrent HGSOC; and pathways containing immune driver genes in optimal vs suboptimal surgical outcomes. Thus, differential DNA methylation identified numerous genes that could serve as potential biomarkers and/or therapeutic targets in HGSOC.

scholarly journals Pooled Clustering of High-Grade Serous Ovarian Cancer Gene Expression Leads to Novel Consensus Subtypes Associated with Survival and Surgical Outcomes

2017 ◽  
Vol 23 (15) ◽  
pp. 4077-4085 ◽  
Author(s):  
Chen Wang ◽  
Sebastian M. Armasu ◽  
Kimberly R. Kalli ◽  
Matthew J. Maurer ◽  
Ethan P. Heinzen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ovarian Cancer ◽  
Surgical Outcomes ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Cancer Gene

scholarly journals Sodium MRI with 3D-cones as a measure of tumour cellularity in high grade serous ovarian cancer

2019 ◽  
Vol 6 ◽  
pp. 156-162 ◽  
Author(s):  
Surrin S. Deen ◽  
Frank Riemer ◽  
Mary A. McLean ◽  
Andrew B. Gill ◽  
Joshua D. Kaggie ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Sodium Mri ◽  
Tumour Cellularity

Molecular predictors of the outcome of paclitaxel plus carboplatin neoadjuvant therapy in high-grade serous ovarian cancer patients

2021 ◽  
Author(s):  
Anna P. Sokolenko ◽  
Tatiana V. Gorodnova ◽  
Ilya V. Bizin ◽  
Ekaterina Sh. Kuligina ◽  
Khristina B. Kotiv ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Neoadjuvant Therapy ◽  
Cancer Patients ◽  
High Grade ◽  
Serous Ovarian Cancer

scholarly journals Precision radiogenomics: fusion biopsies to target tumour habitats in vivo

2021 ◽  
Author(s):  
Mireia Crispin-Ortuzar ◽  
Evis Sala
Keyword(s):  
Ovarian Cancer ◽  
Ct Scans ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
High Degree ◽  
Degree Of Heterogeneity

SummaryHigh-grade serous ovarian cancer lesions display a high degree of heterogeneity on CT scans. We have recently shown that regions with distinct imaging profiles can be accurately biopsied in vivo using a technique based on the fusion of CT and ultrasound scans.

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