PRIMARY IMMUNODEFICIENCY IN BELARUS: FIRST REPORT OF THE NATIONAL REGISTRY OF PID

Author(s):  
Tatjana Uglova
Author(s):  
Jing Pang ◽  
David R. Sullivan ◽  
David L. Hare ◽  
David M. Colquhoun ◽  
Timothy R. Bates ◽  
...  

2016 ◽  
Vol 36 (8) ◽  
pp. 764-773 ◽  
Author(s):  
Štefan Blazina ◽  
Gašper Markelj ◽  
Anja Koren Jeverica ◽  
Nataša Toplak ◽  
Nevenka Bratanič ◽  
...  

Author(s):  
Samaneh Delavari ◽  
Hassan Abolhassani ◽  
Farhad Abolnezhadian ◽  
Fateme Babaha ◽  
Sara Iranparast ◽  
...  

AbstractAlthough it is estimated that COVID-19 life-threatening conditions may be diagnosed in less than 1:1000 infected individuals below the age of 50, but the real impact of this pandemic on pediatric patients with different types of primary immunodeficiency (PID) is not elucidated. The current prospective study on a national registry of PID patients showed that with only 1.23 folds higher incidence of infections, these patients present a 10-folds higher mortality rate compared to population mainly in patients with combined immunodeficiency and immune dysregulation. Therefore, further management modalities against COVID-19 should be considered to improve the survival rate in these two PID entities using hematopoietic stem cell transplantation and immunomodulatory agents.


2014 ◽  
Vol 34 (4) ◽  
pp. 478-490 ◽  
Author(s):  
Asghar Aghamohammadi ◽  
Payam Mohammadinejad ◽  
Hassan Abolhassani ◽  
Babak Mirminachi ◽  
Masoud Movahedi ◽  
...  

2021 ◽  
pp. 7-15
Author(s):  
Carolina A. Isnardi ◽  
Gimena Gómez ◽  
Rosana Quintana ◽  
Karen Roberts ◽  
Guillermo Berbotto ◽  
...  

In order to assess the impact of SARS-CoV-2 infection in patients with rheumatic diseases, the Argentine Society of Rheumatology has developed the National Registry of Patients with Rheumatic Diseases and COVID-19 (SAR-COVID). The aim of this study was to evaluate the sociodemographic and clinical characteristics of patients with rheumatic diseases and SARS-CoV-2 infection included in the SAR-COVID registry and to describe the complications and outcomes of COVID-19 in this population. Methods: SAR-COVID is a national, multicenter and observational registry, in which patients ≥18 years of age, with a diagnosis of a rheumatic disease who had SARS-CoV-2 infection are consecutively included. Sociodemographic data, comorbidities, underlying rheumatic disease and treatment, clinical characteristics, complications, laboratory and treatment of the SARS-CoV-2 infection were recorded. Results: a total of 525 patients were included, with a mean age of 51.3 years (SD 15.2). The most frequent rheumatic diseases were rheumatoid arthritis (40.4%), systemic lupus erythematous (14.9%) and spondyloarthritis (8.2%). At the time of the infection, 72.9% were receiving immunosuppressive or immunomodulatory treatment and 36.9% glucocorticoids. Most of the patients were diagnosed using RT-PCR (95%), at outpatient consultation (39.4%), at the emergency room (32.2%) or during hospitalization (14.7%). Symptoms were present in 96% of the patients, the most frequent being fever (56.2%), cough (46.7%) and headache (39.2%). During infection, 35.1% were hospitalized, 11.6% were admitted to the ICU and 6.9% died due to COVID-19. Most of them (75.1%) recovered completely. Conclusions: in this first report of the SAR-COVID registry we found a wide distribution of rheumatic diseases. Most of the patients had a good evolution of the infection, however 7% died as a result of it, comparable to other Latin American registries with similar populations.


1988 ◽  
Vol 62 (01) ◽  
pp. 141-143 ◽  
Author(s):  
Gerard M. Thomas ◽  
George O. Poinar

A sporulating Aspergillus is described from a piece of Eocene amber originating from the Dominican Republic. The Aspergillus most closely resembles a form of the white spored phase of Aspergillus janus Raper and Thom. This is the first report of a fossil species of Aspergillus.


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