PROGNOSIS OF FASTING ON CEREBRAL VENOUS THROMBOSIS PATIENTS USING ORAL CONTRACEPTIVES

Background: Cerebral venous thrombosis (CVT) is a rare condition (less than 1% of stroke). It occurs in the younger population (less than 50 years old), 3 times more common in women, especially those of reproductive age. Objectives and methodology: Narrative review to correlate CVT with the use of combined oral contraceptives (ACO). The following databases were used: Pubmed, Scielo and Medline. Results: A systematic review had 11 studies included showing that the use of OAC increases the chances of developing CVST (central venous sinus thrombosis). Among the 9 studies that reported odds ratios, the combined probability of developing CVST in women of reproductive age who use OAC was 7.59 times the probability of developing CVST compared to those who do not take oral contraceptives (OR = 7.59, 95 CI % 3.82-15.09). A retrospective study of 37 female adolescents was diagnosed with CVT, 22 (59%) of whom used OAC and the remaining 15 had other etiological factors. The data indicate that adolescents using OAC to treat hirsutism, menstrual dysfunction or polycystic ovary syndrome may also have some risk factors for thrombosis, such as hereditary coagulopathy. The coexistence of these diseases mentioned with the use of OCA can increase the risk of CVT. Conclusions: The two main studies analyzed concluded the association between the use of ACO and cases of CVT in women. It’s necessary to be attentive to suggestive signs and symptoms in this population, as they are common to other pathologies, making the diagnosis of CVT difficult.

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Suspected adverse reaction to compounded preparations prescribed for weight loss: two cases of cerebral venous thrombosis

BMJ Case Reports ◽

10.1136/bcr-2019-233746 ◽

2020 ◽

Vol 13 (3) ◽

pp. e233746 ◽

Cited By ~ 1

Author(s):

Beatrice Mainoli ◽

Mariana Carvalho Dias ◽

Patricia Canhão ◽

Mário Miguel Rosa

Keyword(s):

Weight Loss ◽

Adverse Reaction ◽

Venous Thrombosis ◽

Adverse Drug Reactions ◽

Oral Contraceptives ◽

Cerebral Venous Thrombosis ◽

Drug Reactions ◽

Suspected Adverse Reaction ◽

Life Threatening ◽

Active Substances

We report two cases of cerebral venous thrombosis associated with the use of compounded preparations containing several active substances prescribed for weight loss. In both cases there is suspicion of additive/synergic interaction with oral contraceptives. The adverse drug reactions were considered serious, being life-threatening and causing hospitalisation for days.

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Aggressive treatment of severe acute cerebral venous thrombosis associated with oral contraceptives in young women

Clinical Intensive Care ◽

10.3109/tcic.6.1.36.39 ◽

1995 ◽

Vol 6 (1) ◽

pp. 36-39

Author(s):

R ROSI ◽

A STANCA ◽

M R MONFREGOLA ◽

A MALANDRINI ◽

G M FABRIZI ◽

...

Keyword(s):

Venous Thrombosis ◽

Oral Contraceptives ◽

Young Women ◽

Cerebral Venous Thrombosis ◽

Aggressive Treatment

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Prognosis of fasting in patients with cerebral venous thrombosis using oral contraceptives

Iranian Journal of Neurology ◽

10.18502/ijnl.v18i2.1293 ◽

2019 ◽

Author(s):

Masoud Ghiasian ◽

Maryam Mansour ◽

Nasrin Moradian

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Venous Thrombosis ◽

Oral Contraceptives ◽

Neurological Deficit ◽

Cerebral Venous Thrombosis ◽

Clinical Presentation ◽

Modified Rankin Scale ◽

Focal Neurological Deficit ◽

Muslim Countries

Background: There have been studies that showed a higher incidence of cerebral venous thrombosis (CVT) in Ramadan, a month in which people fast in Muslim countries, which was associated with increasing use of oral contraceptives (OCPs) in women. We aimed to evaluate the effect and prognosis of fasting in patients with CVT using OCPs. Methods: Consecutive patients with diagnosis of CVT in Sina hospital, Hamadan, West of Iran, from May of 2009 to June of 2016 were evaluated, and women using OCPs were included. Other risk factors except fasting were excluded. Clinical presentation and outcomes of CVT was assessed. Patients were followed up for 12 months. Results: 58 patients were included in this study. 31 of these patients had fasting simultaneously. Fasting in patients using OCPs caused significantly higher focal neurological deficit (64.5%, P = 0.018), and higher hemorrhage (66.7%, P = 0.042). At discharge, 51.6% and after three months, 25.8% of patients with fasting had disability [6 > modified Rankin Scale (mRS) >1]. In patients who used OCPs as sole risk factor, 25.9% at discharge and 11.1% after three months had disability. Conclusion: Fasting in patients with CVT using OCPs causes significant increase in focal neurological deficit and hemorrhage, which also increases the hospital stay and lengthens recovery. However, longterm prognosis and mortality of CVT is similar between the two groups.

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