Suspected adverse reaction to compounded preparations prescribed for weight loss: two cases of cerebral venous thrombosis

2020 ◽  
Vol 13 (3) ◽  
pp. e233746 ◽  
Author(s):  
Beatrice Mainoli ◽  
Mariana Carvalho Dias ◽  
Patricia Canhão ◽  
Mário Miguel Rosa
Keyword(s):  
Weight Loss ◽  
Adverse Reaction ◽  
Venous Thrombosis ◽  
Adverse Drug Reactions ◽  
Oral Contraceptives ◽  
Cerebral Venous Thrombosis ◽  
Drug Reactions ◽  
Suspected Adverse Reaction ◽  
Life Threatening ◽  
Active Substances

We report two cases of cerebral venous thrombosis associated with the use of compounded preparations containing several active substances prescribed for weight loss. In both cases there is suspicion of additive/synergic interaction with oral contraceptives. The adverse drug reactions were considered serious, being life-threatening and causing hospitalisation for days.

Life-threatening adverse drug reactions at admission to medical intensive care: a prospective study in a teaching hospital

2007 ◽  
Vol 33 (12) ◽  
pp. 2150-2157 ◽  
Author(s):  
Marieke Grenouillet-Delacre ◽  
Hélène Verdoux ◽  
Nicholas Moore ◽  
Françoise Haramburu ◽  
Ghada Miremont-Salamé ◽  
...  
Keyword(s):  
Intensive Care ◽  
Prospective Study ◽  
Adverse Drug Reactions ◽  
Teaching Hospital ◽  
Drug Reactions ◽  
Life Threatening ◽  
Medical Intensive Care ◽  
A Prospective Study

scholarly journals HLA Association with Drug-Induced Adverse Reactions

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Wen-Lang Fan ◽  
Meng-Shin Shiao ◽  
Rosaline Chung-Yee Hui ◽  
Shih-Chi Su ◽  
Chuang-Wei Wang ◽  
...  
Keyword(s):  
Adverse Drug Reactions ◽  
Antithyroid Drug ◽  
Human Leukocyte ◽  
Stevens Johnson Syndrome ◽  
Drug Reactions ◽  
Drug Induced ◽  
Hla Association ◽  
Hla Genes ◽  
Johnson Syndrome ◽  
Life Threatening

Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated that ADRs possess strong genetic predisposition. ADRs induced by several drugs have been shown to have significant associations with specific alleles of human leukocyte antigen (HLA) genes. For example, hypersensitivity to abacavir, a drug used for treating of human immunodeficiency virus (HIV) infection, has been proposed to be associated with allele 57:01 of HLA-B gene (terms HLA-B∗57:01). The incidences of abacavir hypersensitivity are much higher in Caucasians compared to other populations due to various allele frequencies in different ethnic populations. The antithyroid drug- (ATDs- ) induced agranulocytosis are strongly associated with two alleles: HLA-B∗38:02 and HLA-DRB1∗08:03. In addition, HLA-B∗15:02 allele was reported to be related to carbamazepine-induced SJS/TEN, and HLA-B∗57:01 in abacavir hypersensitivity and flucloxacillin induced drug-induced liver injury (DILI). In this review, we summarized the alleles of HLA genes which have been proposed to have association with ADRs caused by different drugs.

Anticoagulants: Therapeutics, Risks, and Toxicity—Special Emphasis on Heparin-Induced Thrombocytopenia (HIT)

2012 ◽  
Vol 25 (1) ◽  
pp. 22-29 ◽  
Author(s):  
James O’Donnell
Keyword(s):  
At Risk ◽  
Adverse Drug Reactions ◽  
Oral Anticoagulants ◽  
Type A ◽  
Therapeutic Use ◽  
Drug Reactions ◽  
Heparin Induced Thrombocytopenia ◽  
Novel Anticoagulants ◽  
Toxicity Risk ◽  
Life Threatening

Anticoagulants are powerful and unavoidably dangerous drugs that must be carefully selected, monitored, and evaluated. Every patient undergoing treatment is at risk of excess bleeding, since the primary purpose of this class of drugs is to decrease clotting through a variety of biochemical and pharmacological mechanisms. Under the best of circumstances, significant numbers of patients (∼10%) experience toxicity on traditional warfarin oral anticoagulants. Beyond the obvious type A pharmacological toxicity, heparin products carry a seemingly paradoxical/novel risk of increased coagulopathy with limb- and life-threatening thromboembolic injuries (heparin-induced thrombocytopenia [HIT]). As a result of the great toxicity risk, many patients suffer injuries, and litigation is threatened or initiated, frequently against pharmacists and their employers. This article reviews the therapeutic use of old and novel anticoagulants, lists the types of litigation related thereto, and discusses the HIT risk associated with heparin products treatment. Litigation can result from adverse drug reactions and toxicity from anticoagulants.

scholarly journals Consequences of Use

Antibiotics ◽  
2019 ◽  
Author(s):  
Mary Elizabeth Wilson
Keyword(s):  
Adverse Reaction ◽  
Allergic Reaction ◽  
Adverse Drug Reactions ◽  
Signs And Symptoms ◽  
Allergic Reactions ◽  
Drug Reactions ◽  
The Difference

What is the difference between an allergic reaction and an adverse reaction? What are the signs and symptoms of an allergic reaction? All allergic reactions to a drug are adverse drug reactions, but adverse drug reactions also include many other kinds of reactions. Every antibiotic...

scholarly journals Cerebral Venous Thrombosis in Patients Using Oral Contraceptives

10.5772/26615 ◽  
2012 ◽  
Author(s):  
Prochazka Vaclav ◽  
Prochazka Martin ◽  
Lubusky Marek ◽  
Prochazkova Jana ◽  
Hrbac Toma
Keyword(s):  
Venous Thrombosis ◽  
Oral Contraceptives ◽  
Cerebral Venous Thrombosis

Hospital-based survey of doctors' attitudes to adverse drug reactions and perception of drug-related risk for adverse reaction occurrence

1999 ◽  
Vol 8 (S1) ◽  
pp. S27-S35
Author(s):  
Marco Cosentino ◽  
Olivia Leoni ◽  
Cristina Oria ◽  
Donatella Michielotto ◽  
Enrica Massimo ◽  
...  
Keyword(s):  
Adverse Reaction ◽  
Adverse Drug Reactions ◽  
Drug Reactions ◽  
Related Risk
Sign in / Sign up

Export Citation Format

Share Document