PICTURING SEVERITY IN RSV INFECTION, AN ANALYSIS OF INTENSIVE CARE ADMITTED CHILDREN

2017 ◽  
Author(s):  
Pablo Obando Pacheco
Keyword(s):  
Intensive Care ◽  
Rsv Infection

scholarly journals Epidemiology of Respiratory Syncytial Virus-Related Hospitalization Over a 5-Year Period in Italy: Evaluation of Seasonality and Age Distribution Before Vaccine Introduction

Vaccines ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 15
Author(s):  
Federica Barbati ◽  
Maria Moriondo ◽  
Laura Pisano ◽  
Elisa Calistri ◽  
Lorenzo Lodi ◽  
...  
Keyword(s):  
Intensive Care ◽  
Respiratory Syncytial Virus ◽  
Age Distribution ◽  
Vaccine Introduction ◽  
Herd Protection ◽  
Infection Risk Factors ◽  
Rsv Infection ◽  
Syncytial Virus ◽  
Italian Children ◽  
Tract Infections

Respiratory Syncytial Virus (RSV) is associated with most of the acute viral respiratory tract infections causing hospitalization with a peak during the first months of life. Many clinical trials of RSV vaccine candidates are being carried out. The aim of this study was to obtain epidemiologic information to give suggestions on target populations and prevention strategies before the introduction of new vaccines or monoclonal antibodies. We retrospectively evaluated, over a 5-year period (September 2014–August 2019), a population of hospitalized Italian children aged 0–6 years with a laboratory confirmed diagnosis of RSV infection. Risk factors, seasonality of RSV infection, distribution according to age, cases of coinfections and reinfections and cases needing Intensive Care Unit were evaluated. Hospitalizations due to RSV were 624 in the period under study. The peak was found between November and April, with 80.4% of cases recorded between December and February. 62.5% of cases were found in children under three months of age and 41% in children under 30 days old. The need for intensive care was associated with younger ages, with 70.9% of cases in children below three months of age. Unless the incoming vaccines demonstrate a strong herd protection effect, preventive strategies should be aimed at newborns or at maternal immunization.

scholarly journals 1350 Rsv Infection in Infants Admitted to Paediatric Intensive Care Unit

2010 ◽  
Vol 68 ◽  
pp. 668-668
Author(s):  
López A Escobar ◽  
Fernández M Díaz ◽  
Jimeno S Ruiz ◽  
Liana I Martín ◽  
Benedit M Gómez
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Paediatric Intensive Care Unit ◽  
Paediatric Intensive Care ◽  
Rsv Infection

Characteristics of severe RSV infection needing intensive care

2018 ◽  
Vol 177 (9) ◽  
pp. 1407-1408 ◽  
Author(s):  
Bernhard Resch ◽  
Katharina Brunner ◽  
Siegfried Rödl
Keyword(s):  
Intensive Care ◽  
Rsv Infection

scholarly journals The Tale of Stridor and Wheezing in an Infant

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Umer Muhammad ◽  
Marcus Shaffer ◽  
John Bishara
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Human Papillomavirus ◽  
Respiratory Failure ◽  
Pediatric Intensive Care ◽  
Recurrent Respiratory Papillomatosis ◽  
Debulking Surgery ◽  
Vocal Cords ◽  
Pediatric Otolaryngology ◽  
Rsv Infection

Recurrent respiratory papillomatosis is a respiratory disease caused by human papillomavirus and can infect any part of the aerodigestive tract, but the larynx is most involved (Derkay et al. 2010). This report is a discussion about a 7-month-old male that presented to our institution for respiratory distress. He was admitted to the Pediatric Intensive Care Unit (PICU) for stabilization, observation, and further treatment and management due to an acute RSV infection. Initial efforts failed to improve his respiratory failure. A bronchoscopy was performed and showed various flesh-colored lesions throughout the larynx, vocal cords, and tracheal tree just above the carina. Pediatric otolaryngology performed an emergent debulking surgery to alleviate his respiratory failure. He has had multiple exacerbations of his condition since then and has required frequent debulking procedures with a few trials of intralesional bevacizumab therapies.

scholarly journals Describing global pediatric RSV disease at intensive care units in GAVI-eligible countries using molecular point-of-care diagnostics: the RSV GOLD-III study protocol

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yvette N. Löwensteyn ◽  
Natalie I. Mazur ◽  
Harish Nair ◽  
Joukje E. Willemsen ◽  
Ghislaine van Thiel ◽  
...  
Keyword(s):  
Intensive Care ◽  
Intensive Care Units ◽  
Point Of Care ◽  
Mortality Rates ◽  
World Health ◽  
High Dependency ◽  
Severe Acute Respiratory Infection ◽  
Life Threatening ◽  
Rsv Infection ◽  
Syncytial Virus

Abstract Background Respiratory syncytial virus (RSV) infection is an important cause of hospitalization and death in young children. The majority of deaths (99%) occur in low- and lower-middle-income countries (LMICs). Vaccines against RSV infection are underway. To obtain access to RSV interventions, LMICs depend on support from Gavi, the Vaccine Alliance. To identify future vaccine target populations, information on children with severe RSV infection is required. However, there is a lack of individual patient-level clinical data on instances of life-threatening RSV infection in LMICs. The RSV GOLD III—ICU Network study aims to describe clinical, demographic and socioeconomic characteristics of children with life-threatening RSV infection in Gavi-eligible countries. Methods The RSV GOLD-III—ICU Network study is an international, prospective, observational multicenter study and will be conducted in 10 Gavi-eligible countries at pediatric intensive care units and high-dependency units (PICUs/HDUs) during local viral respiratory seasons for 2 years. Children younger than 2 years of age with respiratory symptoms fulfilling the World Health Organization (WHO) “extended severe acute respiratory infection (SARI)” case definition will be tested for RSV using a molecular point-of-care (POC) diagnostic device. Patient characteristics will be collected through a questionnaire. Mortality rates of children admitted to the PICU and/or HDU will be calculated. Discussion This multicenter descriptive study will provide a better understanding of the characteristics and mortality rates of children younger than 2 years with RSV infection admitted to the PICU/HDU in LMICs. These results will contribute to knowledge on global disease burden and awareness of RSV and will directly guide decision makers in their efforts to implement future RSV prevention strategies. Trial registration number: NL9519, May 27, 2021

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