INFECTIVE ENDOCARDITIS CAUSED BY GRANULICATELLA ADIACENS IN CHILDREN - A CASE REPORT

Granulicatella adiacensis a Gram-positive coccus, formerly grouped with nutritionally variantStreptococcus, often found as commensal bacteria of the human oral cavity, urogenital tract, and gastrointestinal tract. Prior case reports have demonstratedGranulicatellaspp. as a pathogen that can cause bacteremia and infective endocarditis particularly of prosthetic valves and pacemaker leads. Here, we report on a unique case ofGranulicatella adiacensbacterascites in a 50-year-old male.

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Infective endocarditis due to Granulicatella adiacens: a case report and review

The Journal of Infection in Developing Countries ◽

10.3855/jidc.3689 ◽

2014 ◽

Vol 8 (04) ◽

pp. 548-550 ◽

Cited By ~ 10

Author(s):

Kanne Padmaja ◽

Vemu Lakshmi ◽

Sreevdya Subramanian ◽

Mamidi Neeraja ◽

Siva Rama Krishna ◽

...

Keyword(s):

Risk Factors ◽

Case Report ◽

Infective Endocarditis ◽

Blood Culture ◽

Treatment Failure ◽

Female Patient ◽

Antimicrobial Therapy ◽

Mortality Rates ◽

Elderly Female ◽

Granulicatella Adiacens

Infective endocarditis (IE) caused by nutritionally variant Streptococci (NVS) is associated with high bacteriologic and treatment failure and mortality rates compared to endocarditis caused by other Streptococci. With automated blood culture systems, the rates of NVS-associated IE accounts for 5%-6% cases. We report a case of IE caused by NVS in an elderly female patient with no risk factors. The patient was successfully treated with combination antimicrobial therapy.

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Native Valve Infective Endocarditis with Osteomyelitis and Brain Abscess Caused by Granulicatella adiacens with Literature Review

Case Reports in Infectious Diseases ◽

10.1155/2019/4962392 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6

Author(s):

Sachin M. Patil ◽

Niraj Arora ◽

Peter Nilsson ◽

S. J. Yasar ◽

Dima Dandachi ◽

...

Keyword(s):

Case Report ◽

Infective Endocarditis ◽

Mitral Valve ◽

Literature Review ◽

Brain Abscess ◽

Antimicrobial Susceptibility ◽

First Case ◽

Tertiary Center ◽

Granulicatella Adiacens ◽

Susceptibility Patterns

Granulicatella adiacens is a type of NVS (nutritionally variant streptococci) rarely causing infective endocarditis (IE). NVS are fastidious and unable to sustain growth on routine culture media due to lack of specific nutrients. Endocarditis caused by NVS due to their virulence is associated with higher treatment failures and mortality rates. New antimicrobial susceptibility patterns are indicative of a significant rise in penicillin resistance and susceptibility differences between NVS subspecies. Initial empirical therapy is essential as a delay in using the appropriate agent leads to poor results. We present a case of an immunocompetent young female with recent intravenous drug abuse resulting in native mitral valve endocarditis with ruptured chordae tendineae and septic embolization, causing brain abscess and lumbar spine osteomyelitis. She was transferred to a tertiary center where she underwent mitral valve replacement successfully and treated with six weeks of intravenous vancomycin and ertapenem. To our knowledge, ours is the first case report of G. adiacens endocarditis in an adult with brain abscess and osteomyelitis with an excellent response to antibiotic therapy. Based on our case report, literature review, and new antimicrobial susceptibility patterns, updates to treatment guidelines are suggested to improve the therapeutic outcomes.

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Can Leg Pain Be the Sole Presenting Symptom of Infective Endocarditis? A Case Report

The Heart Surgery Forum ◽

10.1532/hsf98.20071100 ◽

2007 ◽

Vol 10 (6) ◽

pp. E434-E435

Author(s):

Cevdet Ugur Kocogullari ◽

Alaattin Avsar ◽

Ercüment Ayva ◽

Önder Sahin ◽

Ahmet Cekirdekci

Keyword(s):

Case Report ◽

Infective Endocarditis ◽

Leg Pain

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Discrete Membranous Subaortic Stenosis Complicated by Infective Endocarditis: A Case Report

The Heart Surgery Forum ◽

10.1532/hsf98.20071020 ◽

2007 ◽

Vol 10 (4) ◽

pp. E317-E319

Author(s):

Emre Gurel ◽

Tansu Karaahmet ◽

Ali Tanalp ◽

Bulent Mutlu ◽

Yelda Basaran

Keyword(s):

Case Report ◽

Infective Endocarditis ◽

Subaortic Stenosis

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Bi-microbial Healthcare-Associate Endocarditis caused by Enterococcus faecalis and Burkholderia cepacia: A Case Report and literature review

New Emirates Medical Journal ◽

10.2174/025068xx02666200227171615 ◽

2020 ◽

Vol 02 ◽

Author(s):

Masood Ghori ◽

Nadya O. Al Matrooshi ◽

Samir Al Jabbari ◽

Ahmed Bafadel ◽

Gopal Bhatnagar

Keyword(s):

Case Report ◽

Infective Endocarditis ◽

Literature Review ◽

Enterococcus Faecalis ◽

Surgical Management ◽

Burkholderia Cepacia ◽

Clinical Presentation ◽

Complicated Course ◽

Healthcare Associated ◽

Echocardiographic Findings

: Infective Endocarditis (IE), a known complication of hemodialysis (HD), has recently been categorized as Healthcare-Associated Infective Endocarditis (HAIE). Single pathogen bacteremia is common, polymicrobial endocardial infection is rare in this cohort of the patients. We report a case of endocarditis caused by Enterococcus faecalis (E. faecalis) and Burkholderia cepacia (B. cepacia), a first ever reported combination of a usual and an unusual organism, respectively, in a patient on HD. Clinical presentation of the patient, its complicated course ,medical and surgical management ,along with microbial and echocardiographic findings is presented herein. The authors believe that presentation of this case of HAIE may benefit and contribute positively to cardiac science owing to the rare encounter of this organism as a pathogen in infective endocarditis and the difficulties in treating it.

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Linezolid Induced Skin Reactions in a Multi Drug Resistant Infective Endocarditis Patient: A Rare Case

Current Drug Safety ◽

10.2174/1574886315666200516175053 ◽

2020 ◽

Vol 15 (3) ◽

pp. 222-226 ◽

Cited By ~ 1

Author(s):

Asha K. Rajan ◽

Ananth Kashyap ◽

Manik Chhabra ◽

Muhammed Rashid

Keyword(s):

Case Report ◽

Infective Endocarditis ◽

Rare Case ◽

Case Reports ◽

Multidrug Resistant ◽

The Body ◽

Prior History ◽

Skin Reactions ◽

Rare Case Report ◽

Multiple Drugs

Rationale: Linezolid (LNZ) induced Cutaneous Adverse Drug Reactions (CADRs) have rare atypical presentation. Till date, there are very few published case reports on LNZ induced CADRs among the multidrug-resistant patients suffering from Infective Endocarditis (MDR IE). Here, we present a rare case report of LNZ induced CARs in a MDR IE patient. Case report: A 24-year-old female patient was admitted to the hospital with chief complaints of fever (101°C) associated with rigors, chills, and shortness of breath (grade IV) for the past 4 days. She was diagnosed with MDR IE, having a prior history of rheumatic heart disease. She was prescribed LNZ 600mg IV BD for MDR IE, against Staphylococcus coagulase-negative. The patient experienced flares of cutaneous reactions with multiple hyper-pigmented maculopapular lesions all over the body after one week of LNZ therapy. Upon causality assessment, she was found to be suffering from LNZ induced CADRs. LNZ dose was tapered gradually and discontinued. The patient was prescribed corticosteroids along with other supportive care. Her reactions completely subsided and infection got controlled following 1 month of therapy. Conclusion: Healthcare professionals should be vigilant for rare CADRs, while monitoring the patients on LNZ therapy especially in MDR patients as they are exposed to multiple drugs. Moreover, strengthened spontaneous reporting is required for better quantification.

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