COMPARATIVE STUDY OF SURVIVAL OUTCOMES FOLLOWING ROBOTIC-ASSISTED LAPAROSCOPIC VERSUS ABDOMINAL SURGERY IN THE MANAGEMENT OF OVARIAN CANCER

Abstract Background Laparoscopy has been widely used for patients with early-stage epithelial ovarian cancer (eEOC). However, there is limited evidence regarding whether survival outcomes of laparoscopy are equivalent to those of laparotomy among patients with eEOC. The result of survival outcomes of laparoscopy is still controversial. The aim of this meta-analysis is to analyze the survival outcomes of laparoscopy versus laparotomy in the treatment of eEOC. Methods According to the keywords, Pubmed, Embase, Cochrane Library and Clinicaltrials.gov were searched for studies from January 1994 to January 2021. Studies comparing the efficacy and safety of laparoscopy versus laparotomy for patients with eEOC were assessed for eligibility. Only studies including outcomes of overall survival (OS) were enrolled. The meta-analysis was performed using Stata software (Version 12.0) and Review Manager (Version 5.2). Results A total of 6 retrospective non-random studies were included in this meta-analysis. The pooled results indicated that there was no difference between two approaches for patients with eEOC in OS (HR = 0.6, P = 0.446), progression-free survival (PFS) (HR = 0.6, P = 0.137) and upstaging rate (OR = 1.18, P = 0.54). But the recurrence rate of laparoscopic surgery was lower than that of laparotomic surgery (OR = 0.48, P = 0.008). Conclusions Laparoscopy and laparotomy appear to provide comparable overall survival and progression-free survival outcomes for patients with eEOC. Further high-quality studies are needed to enhance this statement.

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344 Comparison of clinical pathological and survival outcomes between serous and non-serous ovarian cancer

10.1136/ijgc-2020-igcs.296 ◽

2020 ◽

Author(s):

H Mansouri ◽

I Zemni ◽

O Jaidane ◽

M Chemlali ◽

J Ben Hassouna ◽

...

Keyword(s):

Ovarian Cancer ◽

Survival Outcomes ◽

Serous Ovarian Cancer

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Vaginal hysterectomy with or without bilateral salpingo-oophorectomy may be an alternative treatment for endometrial cancer patients with medical co-morbidities precluding standard surgical procedures: a systematic review

International Journal of Gynecological Cancer ◽

10.1136/ijgc-2018-000015 ◽

2019 ◽

Vol 29 (2) ◽

pp. 299-304 ◽

Cited By ~ 1

Author(s):

Arnold-Jan Kruse ◽

Henk G ter Brugge ◽

Harm H de Haan ◽

Hugo W Van Eyndhoven ◽

Hans W Nijman

Keyword(s):

Ovarian Cancer ◽

Endometrial Cancer ◽

Vaginal Hysterectomy ◽

Cancer Survival ◽

Survival Rates ◽

Survival Outcomes ◽

Ovarian Malignancy ◽

Post Menopausal ◽

Ovarian Cancer Survival ◽

Overall Survival Rates

ObjectiveVaginal hysterectomy with bilateral salpingo-oophorectomy may be an alternative strategy for patients with low-risk endometrial cancer and medical co-morbidities precluding laparoscopic or abdominal procedures. The current study evaluates the prevalence of co-existent ovarian malignancy in patients with endometrial cancer and the influence of bilateral salpingo-oophorectomy on survival outcomes in these patients.MethodsMedline and EMBASE were searched for studies published between January 1, 2000 and November 20, 2017 that investigated (1) the prevalence of co-existing ovarian malignancy (either metastases or primary synchronous ovarian cancer in women with endometrial cancer, and (2) the influence of bilateral salpingo-oophorectomy on recurrence and/or survival rates.ResultsOf the pre-menopausal and post-menopausal patients (n=6059), 373 were identified with metastases and 106 were identified with primary synchronous ovarian cancer. Of the post-menopausal patients (n=6016), 362 were identified with metastases and 44 were identified with primary synchronous ovarian cancer. Survival outcomes did not differ for pre-menopausal patients with endometrial cancer with and without bilateral salpingo-oophorectomy (5-year overall survival rates were 89–94.5% and 86–97.8%, respectively).ConclusionBilateral salpingo-oophorectomy during vaginal hysterectomy seems to have a limited impact on disease outcome in patients with endometrial cancer. These results support the view that vaginal hysterectomy alone or with bilateral salpingo-oophorectomy may be an option for patients with endometrial cancer who are not ideal surgical candidates.

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