Interpretability of the Patient-Reported Multiple Sclerosis Neuropsychological Screening Questionnaire: a cognitive screening tool?

2017 ◽  
Author(s):  
Ilse M. Nauta
Keyword(s):  
Multiple Sclerosis ◽  
Screening Tool ◽  
Cognitive Screening ◽  
Screening Questionnaire ◽  
Neuropsychological Screening ◽  
Patient Reported

scholarly journals The clinical value of the patient-reported multiple sclerosis neuropsychological screening questionnaire

2018 ◽  
Vol 25 (11) ◽  
pp. 1543-1546 ◽  
Author(s):  
Ilse M Nauta ◽  
Lisanne J Balk ◽  
Judith M Sonder ◽  
Hanneke E Hulst ◽  
Bernard MJ Uitdehaag ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Operating Characteristic ◽  
Cognitively Impaired ◽  
Clinical Value ◽  
Screening Questionnaire ◽  
Neuropsychological Screening ◽  
Impaired Cognitive Function ◽  
Clinical Applicability ◽  
Patient Reported ◽  
Cognitive Problems

Background: Cognitive problems are difficult to identify in patients with multiple sclerosis (MS). Objective: To investigate the clinical applicability of the patient-reported MS Neuropsychological Screening Questionnaire (MSNQ-P). Methods: Cut-off scores were determined to differentiate between cognitively impaired ( n = 90), mildly cognitively impaired ( n = 115), and cognitively preserved ( n = 147) MS patients using receiver operating characteristic analyses. Results: We could not define specific and sensitive cut-off scores. Higher scores (≥27) did indicate cognitive impairment. Among patients with a higher education, lower scores (<12) indicated intact cognition. Conclusion: Certain scores can indicate intact or impaired cognitive function. Still, MSNQ-P scores should be interpreted with caution.

Multiple Sclerosis Neuropsychological Screening Questionnaire--Italian Version

2021 ◽  
Author(s):  
Simone Migliore ◽  
Doriana Landi ◽  
Francesca Proietti ◽  
Giulia D’Aurizio ◽  
Ferdinando Squitieri ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Italian Version ◽  
Screening Questionnaire ◽  
Neuropsychological Screening

Integrating Cognitive Function Screening and Assessment into the Routine Care of Multiple Sclerosis Patients

CNS Spectrums ◽  
2005 ◽  
Vol 10 (5) ◽  
pp. 384-391 ◽  
Author(s):  
Ralph H.B. Benedict
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Function ◽  
Neuropsychological Testing ◽  
Routine Care ◽  
Good Test ◽  
Retest Reliability ◽  
Screening Questionnaire ◽  
Neuropsychological Screening ◽  
Multiple Sclerosis Patients ◽  
Test Retest Reliability

AbstractCognitive dysfunction, a common feature of multiple sclerosis (MS), frequently leads to impaired activities of daily living, social skills deficits, diminished social support, and unemployment. There is growing evidence indicating that cognitive impairment is amenable to the effects of medication and behavioral counseling. Unfortunately, routine neuropsychological testing is rare in MS clinics because screening is ineffective and testing strategies are often too cumbersome or expensive. Recent research supports the reliability of a brief screening test called the Multiple Sclerosis Neuropsychological Screening Questionnaire as well as a minimal neuropsychological battery called the Minimal Assessment of Cognitive Function in Multiple Sclerosis. Data indicate that the Multiple Sclerosis Neuropsychological Screening Questionnaire has excellent split-half and test-retest reliability, and that it predicts neuropsychological deficiency with good sensitivity and specificity. Recently acquired data also show that the Minimal Assessment of Cognitive Function in Multiple Sclerosis tests have good test-retest reliability, discriminate MS patients from normal controls, and predict unemployment in MS patients. Thus, these or similar methods should be employed for the routine monitoring of cognitive functioning of MS patients.

scholarly journals The feasibility, reliability and concurrent validity of the MSReactor computerized cognitive screening tool in multiple sclerosis

2019 ◽  
Vol 12 ◽  
pp. 175628641985918 ◽  
Author(s):  
Daniel Merlo ◽  
David Darby ◽  
Tomas Kalincik ◽  
Helmut Butzkueven ◽  
Anneke van der Walt
Keyword(s):  
Multiple Sclerosis ◽  
Screening Tool ◽  
Practice Effects ◽  
Cognitive Test ◽  
Cognitive Screening ◽  
Cognitive Changes ◽  
Discriminative Ability ◽  
Monitoring Tools ◽  
Home Based ◽  
Home Testing

Background: Multiple sclerosis (MS) cognitive tests are resource intensive and limited by practice effects that prevent frequent retesting. Brief, reliable and valid monitoring tools are urgently needed to detect subtle, subclinical cognitive changes in people with MS. Cognitive monitoring over time could contribute to a new definition of disease progression, supplementing routine clinical monitoring. Methods: MSReactor is a web-based battery that measures psychomotor (processing) speed, visual attention and working memory, using simple reaction time tasks. Clinic-based tasks were completed at baseline and 6 monthly with home testing 1–3 monthly. Acceptability, quality of life, depression and anxiety surveys were completed. We studied its correlation with the Symbol Digit Modalities Test, practice effects, test–retest reliability and the discriminative ability of MSReactor. Results: A total of 450 people with MS were recruited over 18 months, with 81% opting to complete home-based testing. Most participants (96%) would be happy (or neutral) to repeat the tasks again and just four reported the tasks made them ‘very anxious’. Persistence of home testing was high and practice effects stabilized within three tests. MSReactor tasks correlated with Symbol Digit Modalities Test scores and participants with MS performed slower than healthy controls. Conclusion: MSReactor is a scalable and reliable cognitive screening tool that can be used in the clinic and remotely. MSReactor task performance correlated with another highly validated cognitive test, was sensitive to MS and baseline predictors of cognitive performance were identified.

Proxy measurements in multiple sclerosis: agreement on different patient-reported outcome scales

2011 ◽  
Vol 18 (2) ◽  
pp. 196-201 ◽  
Author(s):  
JM Sonder ◽  
LVAE Bosma ◽  
FAH van der Linden ◽  
DL Knol ◽  
CH Polman ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Psychological Functioning ◽  
Correlation Coefficients ◽  
Patient Reported Outcome ◽  
Neuropsychological Screening ◽  
Psychological Scale ◽  
Impact Scale ◽  
Patient Reported ◽  
Good For ◽  
Cognitive Problems

Background: Patient-reported outcome (PRO) scales are often used in multiple sclerosis (MS) research. Full understanding of items can be influenced by disease worsening, mood disturbances and cognitive problems of the MS patient. Earlier research with the Multiple Sclerosis Impact Scale (MSIS-29) showed that proxy respondents (i.e. partners of patients) can provide useful information. Objective: To determine agreement between patients and proxy respondents on different MS PRO scales. Methods: 139 Patients and partners completed the MSIS-29 (Physical and Psychological scale), Multiple Sclerosis Walking Scale (MSWS-12), Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ) and Guy’s Neurological Disability Scale (GNDS). We calculated the mean difference and intra-class correlation coefficients (ICC) on scale level and weighted kappas (κw) on item level. Results: On all scales, except MSNQ, the partner score was higher. ICCs were good for MSWS, GNDS and MSIS Physical, and moderate for MSNQ and MSIS Psychological. κw was excellent for MSWS items, fair to good for GNDS, MSIS Physical and MSIS Psychological items, and poor for MSNQ items. Conclusion: Partners of patients with MS can be a useful source of information for several PRO scales, especially when the focus is on physical functioning. For psychological functioning this seems to be less reliable.

Validation of cognitive screening tool to predict fitness-to-drive in individuals with multiple sclerosis

Physiotherapy ◽  
2015 ◽  
Vol 101 ◽  
pp. e45
Author(s):  
H. Devos ◽  
A. Cornelison ◽  
E. De La Cruz ◽  
T. Harris ◽  
K. Phillips ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Screening Tool ◽  
Cognitive Screening ◽  
Fitness To Drive

Validation of the Multiple Sclerosis Neuropsychological Screening Questionnaire in Argentina

2008 ◽  
Vol 15 (2) ◽  
pp. 244-250 ◽  
Author(s):  
S Vanotti ◽  
RHB Benedict ◽  
L Acion ◽  
F Cáceres ◽  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
High Risk ◽  
Reliability And Validity ◽  
Patient Report ◽  
Screening Questionnaire ◽  
Neuropsychological Screening ◽  
Neuropsychological Status ◽  
Report Measure ◽  
Normal Controls

Backgrounds Considering the lack of screening technology that would permit neurologists to identify patients who may benefit from formal or more comprehensive assessment of neuropsychological status in patients with multiple sclerosis (MS) in Argentina, we felt the need to validate the Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ) developed by Benedict, et al. Objective The objective in this multicenter study was to test the reliability and validity of the MSNQ after translation into Spanish in Argentina. We also compared the MSNQ yield by the patient report with that of the two different informants. The sample included 125 patients with MS and 36 normal controls, 27 patients had two informants available and 23 patients and their informants were examined twice at 1-week intervals (test–retest group). All participants completed the MSNQ, RAO BRB, Beck Depression Inventory-Fast Screen, EDSS, and MS Functional Composite. Results We found that an MSNQ-I score of 26 or more resulted in classifications yielding sensitivity of 0.91 and specificity of 0.80, suggesting some utility for this Argentine, informant-report measure. Conclusions This Spanish version of the MSNQ is reliable and useful as a screening test for identifying patients at high risk for cognitive impairment in MS.

scholarly journals A Greek Validation Study of the Multiple Sclerosis Work Difficulties Questionnaire-23

Healthcare ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 897
Author(s):  
Christos Bakirtzis ◽  
Artemios Artemiadis ◽  
Elli Nteli ◽  
Marina Kleopatra Boziki ◽  
Maria-Valeria Karakasi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Internal Consistency ◽  
Convergent Validity ◽  
Goodness Of Fit ◽  
Self Report ◽  
Full Time ◽  
Cognitive Screening ◽  
Cronbach’S Alpha ◽  
Cronbach's Alpha ◽  
Patient Reported

The Multiple Sclerosis Work Difficulties Questionnaire-23 (MSWDQ-23) is a self-report instrument developed to assess barriers faced by People with Multiple Sclerosis (PwMS) in the workplace. The aim of this study was to explore the psychometric properties of the Greek version of the MSWDQ-23. The study sample consisted of 196 PwMS, all currently working in part- or full-time jobs. Participants underwent clinical examination and cognitive screening with the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) and completed self-report measures of fatigue, psychological functioning, and quality of life, along with the MSWDQ-23 questionnaire. Confirmatory Factor Analysis (CFA) was performed, and goodness-of-fit measures were used to evaluate construct validity. Convergent validity was checked by correlating MSWDQ-23 scores with study measures. Cronbach’s alpha value was produced to assess internal consistency. CFA yielded a model with a fair fit confirming the three-factor structure of the instrument. Higher work difficulties were associated with higher Expanded Disability Status Scale (EDSS) scores, poorer cognitive function, more fatigue, stress, anxiety, and depression, and poorer health status, supporting the convergent validity of MSWDQ-23. Internal consistency (Cronbach’s alpha = 0.94) and test–retest reliability (ICC = 0.996, 95%, CI = 0.990–0.998) were excellent. The Greek MSWDQ-23 can be considered a valid patient-reported outcome measure and can be used in interventions aiming to improve the vocational status of PwMS.

Validity of the Italian multiple sclerosis neuropsychological screening questionnaire

2021 ◽  
Author(s):  
Simone Migliore ◽  
Doriana Landi ◽  
Francesca Proietti ◽  
Giulia D’Aurizio ◽  
Ferdinando Squitieri ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Screening Questionnaire ◽  
Neuropsychological Screening

Rapid cognitive screening in multiple sclerosis accomplished by the Free Recall and Recognition Test

2007 ◽  
Vol 13 (2) ◽  
pp. 272-274 ◽  
Author(s):  
Im Claesson ◽  
C Ytterberg ◽  
S Johansson ◽  
O Almkvist ◽  
L Von Koch
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Free Recall ◽  
Disease Severity ◽  
Recognition Test ◽  
Screening Tool ◽  
Cognitive Tests ◽  
Cognitive Screening ◽  
Severity Rating ◽  
Serial Addition

This study sought to investigate the feasibility of the Free Recall and Recognition Test (FRRT) as a practical screening tool for cognitive impairment in multiple sclerosis (MS). Persons with MS (n =227) were consecutively recruited and assessed with four cognitive tests; FRRT, Symbol Digit Modalities Test (SDMT), Paced Auditory Serial Addition Test (PASAT), and the Mini-Mental State Examination (MMSE). Disease severity was assessed by the Expanded Disability Status Scale (EDSS). The FRRT, which was completed by 99% of the cohort in approximately 5 minutes per assessment, correlated significantly with the other cognitive tests, as well as with the disease severity rating. A cut-off of 4 for the FRRT recall rendered 90% sensitivity and 25% specificity, and a cut-off of 4.2 for the FRRT recognition resulted in 70% sensitivity and 51% specificity. We conclude that the FRRT proved feasible as a practical screening tool for cognitive impairment in MS within a clinical setting. Multiple Sclerosis 2007; 13: 272–274. http://msj.sagepub.com

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