A long-term pretreatment with GnRH agonists prior to IVF/ICSI does not improve the clinical pregnancy rate in patients with endometriosis: a systematic review.

Introduction:The aim of the systematic review (SR) is to evaluate the efficacy of Acupuncture in endometrium receptivity(ER) of infertile women and find out dose-related between Acupuncture and clinical pregnancy rate. Methods and analysis: We will search four English databases: PubMed, Embase, Cochrane Library, Web of Science, and five Chinese databases: SinoMed (formerly Chinese Biomedical Database), CNKI (Chinese National Knowledge Infrastructure), Wanfang Data, and China Biomedical Literature Database (CBM), China Science Journal Database (VIP database) from inception to February 2021 in English and Chinese. Also, we will manually retrieve other resources, including reference lists of identified publications, conference articles, and grey literature. All clinical randomized controlled trials related to Acupuncture for endometrium receptivity of infertile women will be included. Two review authors will perform all research selection, data extraction, and research quality assessment. According to suggestions, data will be synthesized in a fixed-effect model, or random effect model due to the heterogeneity test. The primary outcomes include ER (endometrial thickness and endometrial hemodynamic parameters) and clinical pregnancy rate(CPR). Secondary outcomes include a dose of the interventions( the starting time of Acupuncture, the duration, and frequency of Acupuncture sessions), and adverse events will be assessed. We will use the statistical package (RevMan5.4.0) provided by The Cochrane Collaboration to analyze data. The quality of evidence will be assessed by using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework. Ethics and dissemination: Since this article does not contain patient personal information, ethical approval is not required. The contract is distributed by a peer-review Systematic review registration: PROSPERO, CRD42020206790

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Sequential cleavage and blastocyst embryo transfer and IVF outcomes: a systematic review

Reproductive Biology and Endocrinology ◽

10.1186/s12958-021-00824-y ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Jianeng Zhang ◽

Chong Wang ◽

Huanhuan Zhang ◽

Yan Zhou

Keyword(s):

Systematic Review ◽

Pregnancy Rate ◽

Embryo Transfer ◽

Fixed Effects ◽

Clinical Pregnancy ◽

Clinical Pregnancy Rate ◽

Cochrane Library ◽

Fixed Effects Model ◽

Ivf Outcomes ◽

Transfer Group

Abstract Background Sequential embryo transfer has been proposed as a way to improve embryo implantation in women for in vitro fertilization (IVF), but the effect on pregnancy outcomes remains ambiguous. This systematic review was conducted to investigate the efficacy of sequential embryo transfer on IVF outcomes. Methods A literature search was performed in the PubMed, Web of Science, Cochrane Library, ScienceDirect and Wanfang databases. Data were pooled using a random- or fixed-effects model according to study heterogeneity. The results are expressed as relative risks (RRs) with 95% confidence intervals (CIs). Heterogeneity was evaluated by the I2 statistic. The study protocol was registered prospectively on INPLASY, ID: INPLASY202180019. Results Ten eligible studies with 2658 participants compared sequential embryo transfer and cleavage transfer, while four studies with 513 participants compared sequential embryo transfer and blastocyst transfer. The synthesis results showed that the clinical pregnancy rate was higher in the sequential embryo transfer group than in the cleavage embryo transfer group (RR 1.42, 95% CI 1.26–1.60, P< 0.01) for both women who did experience repeated implantation failure (RIF) (RR 1.58, 95% CI 1.17–2.13, P< 0.01) and did not experience RIF (Non-RIF) (RR 1.44, 95% CI 1.20–1.66, P< 0.01). However, sequential embryo transfer showed no significant benefit over blastocyst embryo transfer. Conclusion The current systematic review demonstrates that sequential cleavage and blastocyst embryo transfer improve the clinical pregnancy rate over conventional cleavage embryo transfer. For women with adequate embryos, sequential transfer could be attempted following careful consideration. More high-grade evidence from prospective randomized studies is warranted.

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The effect of unilateral tubal block on clinical pregnancy rate in intrauterine insemination cycles: Systematic review & meta-analysis

10.26226/morressier.5af300ad738ab10027aa91ed ◽

2018 ◽

Author(s):

Justin Tan ◽

Arohumam Kan

Keyword(s):

Systematic Review ◽

Pregnancy Rate ◽

Intrauterine Insemination ◽

Meta Analysis ◽

Clinical Pregnancy ◽

Clinical Pregnancy Rate

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Glucocorticoids Improves Pregnancy Rate and Outcome in Woman With Unexplained Positive Autoantibody: a Systematic Review and Meta-analysis

10.21203/rs.3.rs-147807/v1 ◽

2021 ◽

Author(s):

Ting Li ◽

Yilin Yuan ◽

Huixin Liu ◽

Qun Lu ◽

Rong Mu

Keyword(s):

Systematic Review ◽

Pregnancy Rate ◽

Pregnancy Outcome ◽

Live Birth ◽

Birth Rate ◽

Meta Analysis ◽

Live Birth Rate ◽

Clinical Pregnancy ◽

Clinical Pregnancy Rate ◽

Cochrane Central Register

Abstract Background: The effect of glucocorticoids (GCs) therapy for women with unexplained positive autoantibody is under debate. This systematic review and meta-analysis was performed to evaluate whether GCs administration can improve the pregnancy outcome of this population.Methods: A meta-analysis based on a systematic review of PubMed, Embase, EBSCO, and the Cochrane Central Register of Controlled Trials, until January 2021, was used to evaluate pregnancy outcome of GCs treatment for women with unexplained recurrent fetal loss or infertility whose autoantibody positive, but does not meet any classification criteria for autoimmune diseases.Results: We found GCs treatment improved clinical pregnancy rate (RR 2.19, 95% CI 1.64 to 2.92) and live birth rate (RR 1.92, 95% CI 1.17 to 3.16), especially when started GCs administration before pregnancy (clinical pregnancy rate: RR 2.30, 95% CI 1.58 to 3.34; live birth rate: RR 2.30, 95% CI 1.58 to 3.34). However, no effect of GCs on miscarriage rate was found (RR 0.75, 95% CI 0.55 to 1.02) regardless of time of drug administration.Conclusions: Our systematic review and meta-analysis surports the rational use of GCs in women with unexplained positive autoantibody.

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