Epigenetic regulation of BDNF expression in auditory cortex of neonatal chicks in response to prenatal sound stimulation

2018 ◽  
Author(s):  
Poorti Kathpalia ◽  
TAPAS CHANDRA NAG
Keyword(s):  
Auditory Cortex ◽  
Epigenetic Regulation ◽  
Sound Stimulation ◽  
Bdnf Expression ◽  
Neonatal Chicks

In ovo Sound Stimulation Mediated Regulation of BDNF in the Auditory Cortex and Hippocampus of Neonatal Chicks

Neuroscience ◽  
2019 ◽  
Vol 408 ◽  
pp. 293-307 ◽  
Author(s):  
Poorti Kathpalia ◽  
Tapas Chandra Nag ◽  
Parthaprasad Chattopadhyay ◽  
Arundhati Sharma ◽  
Muzaffer Ahmed Bhat ◽  
...  
Keyword(s):  
Auditory Cortex ◽  
Sound Stimulation ◽  
In Ovo ◽  
Neonatal Chicks

Neural interaction in cat primary auditory cortex II. Effects of sound stimulation

1994 ◽  
Vol 71 (1) ◽  
pp. 246-270 ◽  
Author(s):  
J. J. Eggermont
Keyword(s):  
Auditory Cortex ◽  
Cortical Neurons ◽  
Relative Size ◽  
Primary Auditory Cortex ◽  
Mean Value ◽  
Neural Synchrony ◽  
Sound Stimulation ◽  
Common Input ◽  
Neural Correlation ◽  
The Mean

1. The effect of auditory stimulation with click trains, noise bursts, amplitude-modulated noise bursts, and amplitude-modulated tone bursts on the correlation of firing of 1,290 neuron pairs recorded on one or two electrodes in primary auditory cortex of the cat was investigated. A distinction was made between neural synchrony (the correlation under stimulus conditions) and neural correlation (the correlation under spontaneous or under stimulus conditions after correction for stimulus-related correlations). For neural correlation 63% of the single-electrode pairs showed a unilateral excitation component, often combined with a common-input peak, and only 11% of the dual electrode pairs showed this unilateral excitation. 2. Under poststimulus conditions the incidence of correlograms with clear peaks was high for single-electrode pairs (80–90% range) and somewhat lower for dual-electrode pairs (50–60% range). The strength of the neural correlation for poststimulus conditions, from 0.5 to 2 s after a 1-s stimulus, was comparable with that obtained for 15-min continuous silence, suggesting that aftereffects of stimulation had largely disappeared after 0.5 s. A stationary analysis of the correlation coefficient corroborated this. 3. Two stimulus-correction procedures, one based on the shift predictor and the other based on the joint peristimulus-time histogram (JPSTH) were compared. The mean value of the neural correlation under stimulus conditions obtained after applying the poststimulus time (PST) predictor was on average 20% larger than the mean value obtained after application of the shift predictor; however, this was not significantly different at the 0.05 level. There were no differences in the shape of the correlograms. This suggests that the less time-consuming shift predictor-based stimulus-correction procedure can be used for cortical neurons. 4. Under stimulus conditions neural correlation coefficients could be < or = 50% smaller than for spontaneous conditions. The strength of the stimulus-corrected neural correlation was inversely related to the relative size of the stimulus predictor (compared with the neural synchrony) and thus to the effectiveness of stimulation. This suggests that the assumption of additivity of stimulus and connectivity effects on neural synchrony is generally violated both for shift predictor and PST predictor procedures. 5. The neural correlogram peaks were narrower for single-electrode pairs than for dual-electrode pairs both under stimulus and spontaneous conditions. Under stimulus conditions the peaks were generally narrower than under spontaneous firing conditions.(ABSTRACT TRUNCATED AT 400 WORDS)

scholarly journals Gestational stress induces depressive-like and anxiety-like phenotypes through epigenetic regulation of BDNF expression in offspring hippocampus

Epigenetics ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. 150-162 ◽  
Author(s):  
Yu Zheng ◽  
Weidong Fan ◽  
Xianquan Zhang ◽  
Erbo Dong
Keyword(s):  
Epigenetic Regulation ◽  
Bdnf Expression ◽  
Gestational Stress

Sensitivity to Simulated Directional Sound Motion in the Rat Primary Auditory Cortex

1999 ◽  
Vol 81 (5) ◽  
pp. 2075-2087 ◽  
Author(s):  
Daryl E. Doan ◽  
James C. Saunders
Keyword(s):  
Auditory Cortex ◽  
Horizontal Plane ◽  
Tuning Curve ◽  
Primary Auditory Cortex ◽  
Neuron Activity ◽  
Sound Location ◽  
Sound Stimulation ◽  
Adult Rats ◽  
Sound Motion ◽  
Simulated Motion

Sensitivity to simulated directional sound motion in the rat primary auditory cortex. This paper examines neuron responses in rat primary auditory cortex (AI) during sound stimulation of the two ears designed to simulate sound motion in the horizontal plane. The simulated sound motion was synthesized from mathematical equations that generated dynamic changes in interaural phase, intensity, and Doppler shifts at the two ears. The simulated sounds were based on moving sources in the right frontal horizontal quadrant. Stimuli consisted of three circumferential segments between 0 and 30°, 30 and 60°, and 60 and 90° and four radial segments at 0, 30, 60, and 90°. The constant velocity portion of each segment was 0.84 m long. The circumferential segments and center of the radial segments were calculated to simulate a distance of 2 m from the head. Each segment had two trajectories that simulated motion in both directions, and each trajectory was presented at two velocities. Young adult rats were anesthetized, the left primary auditory cortex was exposed, and microelectrode recordings were obtained from sound responsive cells in AI. All testing took place at a tonal frequency that most closely approximated the best frequency of the unit at a level 20 dB above the tuning curve threshold. The results were presented on polar plots that emphasized the two directions of simulated motion for each segment rather than the location of sound in space. The trajectory exhibiting a “maximum motion response” could be identified from these plots. “Neuron discharge profiles” within these trajectories were used to demonstrate neuron activity for the two motion directions. Cells were identified that clearly responded to simulated uni- or multidirectional sound motion (39%), that were sensitive to sound location only (19%), or that were sound driven but insensitive to our location or sound motion stimuli (42%). The results demonstrated the capacity of neurons in rat auditory cortex to selectively process dynamic stimulus conditions representing simulated motion on the horizontal plane. Our data further show that some cells were responsive to location along the horizontal plane but not sensitive to motion. Cells sensitive to motion, however, also responded best to the moving sound at a particular location within the trajectory. It would seem that the mechanisms underlying sensitivity to sound location as well as direction of motion converge on the same cell.

scholarly journals Optical recording of neural activities of guinea pig auditory cortex in response to sound stimulation.

1998 ◽  
Vol 38 (1) ◽  
pp. 14-17
Author(s):  
Junsei HORIKAWA ◽  
Ikuo TANIGUCHI
Keyword(s):  
Guinea Pig ◽  
Auditory Cortex ◽  
Optical Recording ◽  
Sound Stimulation ◽  
Neural Activities

scholarly journals Long-term Administration of Salicylate-induced Changes in BDNF Expression and CREB Phosphorylation in the Auditory Cortex of Rats

2018 ◽  
Vol 39 (3) ◽  
pp. e173-e180 ◽  
Author(s):  
Bin Yi ◽  
Cong Wu ◽  
Runjie Shi ◽  
Kun Han ◽  
Haibin Sheng ◽  
...  
Keyword(s):  
Auditory Cortex ◽  
Bdnf Expression ◽  
Creb Phosphorylation ◽  
Term Administration ◽  
Induced Changes
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