Relationship between histological type and PD-L1 expression in non-small cell lung cancer (NSCLC)

Introduction. Lung cancer is one of the most common malignant neoplasms, as well as the most common cause of death cancer. Most lung cancers are squamous cell carcinomas, small cell carcinomas or adenocarcinomas. Objective. Examining changes in trends of lung cancer incidence in Montenegro by histological type during a 15-year period, from 1997 to 2011. Methods. During the study period, histopathological confirmation was obtained for all primary lung cancer cases in the only hospital for lung diseases in the country. Based on the data from medical records, patients were classified by time period, sex, age groups and smoking history. Descriptive method was used. Results. Ratio between incidences of adenocarcinoma and squamous cell carcinoma changes in males, with a significant increase in the incidence rate of adenocarcinoma and drop in the rate of squamous cell carcinoma (p<0.001). In addition, statistically significant (p<0.05) decrease in the incidence of NSCLC (non-small cell lung cancer) and an increase in the incidence of SCLC (small cell lung cancer) was found. A statistically significant increase in linear trend in the incidence of small cell carcinoma was noted in females (p<0.005). Conclusion. Incidence rates of adenocarcinoma and small cell carcinoma have increased during the study period.

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Histological type predicts mediastinal metastasis and surgical outcome in resected cN1 non-small cell lung cancer

General Thoracic and Cardiovascular Surgery ◽

10.1007/s11748-017-0799-4 ◽

2017 ◽

Vol 65 (9) ◽

pp. 519-526 ◽

Cited By ~ 3

Author(s):

Tetsuya Mizuno ◽

Takaaki Arimura ◽

Hiroaki Kuroda ◽

Noriaki Sakakura ◽

Yasushi Yatabe ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Surgical Outcome ◽

Small Cell ◽

Histological Type ◽

Small Cell Lung ◽

Mediastinal Metastasis

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Preoperative systemic immune-inflammation index predicts prognosis and guides clinical treatment in patients with non-small cell lung cancer

Bioscience Reports ◽

10.1042/bsr20200352 ◽

2020 ◽

Vol 40 (3) ◽

Cited By ~ 1

Author(s):

Xue Yan ◽

Guowei Li

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Prognostic Value ◽

Multivariate Analyses ◽

Small Cell ◽

Histological Type ◽

Pathological Stage ◽

Small Cell Lung ◽

Lymphocyte Ratio

Abstract Objectives: The purpose of the present study was to evaluate the prognostic value of a systemic immune-inflammation index (SII) and the relationship between SII and the effectiveness of postoperative treatment in patients with non-small cell lung cancer (NSCLC). Methods: A total of 538 patients diagnosed with NSCLC who had undergone curative surgery were retrospectively enrolled in the study. Clinicopathologic and laboratory variables were collected. SII was defined as neutrophil × platelet/lymphocyte counts. Both univariate and multivariate analyses were performed to analyze the prognostic value of these factors. Results: The preoperative SII level was associated with sex, smoking history, histological type, lesion type, resection type, pathological stage, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR), fibrinogen and bone metastasis (P<0.05). The univariate and multivariate analyses revealed that SII was an independent prognostic factor for disease-free survival (DFS, P=0.033) and overall survival (OS, P=0.020). Furthermore, the prognostic value of SII was also verified regardless of the histological type and pathological stage. The subgroup analysis demonstrated that patients with a high SII may benefit from adjuvant therapy (P=0.024 for DFS and P=0.012 for OS). Conclusion: An increased preoperative SII may independently predict the poor DFS and OS in patients with resectable NSCLC. SII may help select NSCLC patients who might benefit from adjuvant chemotherapy.

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Prognostic value of tumor-infiltrating lymphocytes differs depending on histological type and smoking habit in completely resected non-small-cell lung cancer

Annals of Oncology ◽

10.1093/annonc/mdw319 ◽

2016 ◽

Vol 27 (11) ◽

pp. 2117-2123 ◽

Cited By ~ 58

Author(s):

T. Kinoshita ◽

R. Muramatsu ◽

T. Fujita ◽

H. Nagumo ◽

T. Sakurai ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Prognostic Value ◽

Smoking Habit ◽

Tumor Infiltrating Lymphocytes ◽

Small Cell ◽

Histological Type ◽

Small Cell Lung ◽

Infiltrating Lymphocytes

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Influence of histological type, smoking history and chemotherapy on survival after first-line therapy in patients with advanced non-small cell lung cancer

Cancer Science ◽

10.1111/j.1349-7006.2006.00379.x ◽

2007 ◽

Vol 98 (2) ◽

pp. 226-230 ◽

Cited By ~ 24

Author(s):

Toru Itaya ◽

Nobuyuki Yamaoto ◽

Masahiko Ando ◽

Masako Ebisawa ◽

Yukiko Nakamura ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Histological Type ◽

Smoking History ◽

Small Cell Lung ◽

First Line ◽

First Line Therapy ◽

Line Therapy

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Differences in the efficacy of S-1 monotherapy according to histological type in pretreated patients with advanced non-small cell lung cancer

Thoracic Cancer ◽

10.1111/1759-7714.12071 ◽

2014 ◽

Vol 5 (2) ◽

pp. 121-125 ◽

Cited By ~ 1

Author(s):

Yasushi Hisamatsu ◽

Haruyasu Murakami ◽

Hiroaki Akamatsu ◽

Madoka Kimura ◽

Keita Mori ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Histological Type ◽

Small Cell Lung ◽

Pretreated Patients

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Preoperative CEA, NSE, SCC, TPA and CYFRA 21.1 Serum Levels as Prognostic Indicators in Resected Non-Small Cell Lung Cancer

The International Journal of Biological Markers ◽

10.1177/172460089901400206 ◽

1999 ◽

Vol 14 (2) ◽

pp. 92-98 ◽

Cited By ~ 7

Author(s):

P. Foa ◽

M. Fornier ◽

R. Miceli ◽

E. Seregni ◽

L. Santambrogio ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Prognostic Significance ◽

Predictive Ability ◽

Serum Levels ◽

Small Cell ◽

Histological Type ◽

Pathological Stage ◽

Small Cell Lung

In 62 patients affected by resectable non-small cell lung cancer (NSCLC) submitted to radical surgery we evaluated the prognostic significance of CEA, NSE, SCC, TPA and CYFRA 21.1 serum levels at diagnosis, as well as the predictive ability of these tumor markers with respect to histological type and pathological stage. The group was composed of 56 male and 6 female patients; the median age was 62 years (range 29–73 years). Thirty-four patients had a histological diagnosis of adenocarcinoma and 28 of squamous cell carcinoma; with regard to pathological stage, 32 patients had stage I, 4 patients stage II and 23 patients stage IIIA disease. A good predictive ability with respect to histological type was obtained with SCC serum levels; as for pathological stage, TPA and CYFRA 21.1 were found to have moderate predictive ability. In this series of patients, at a median follow-up of 55 months after surgery, we found that both TPA and CYFRA 21.1 serum levels at diagnosis were reliable predictors of overall survival, high values of these markers being associated with a worse prognosis.

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