scholarly journals 5 - The role of an Enzyme-Alginogel (Flaminal® Forte) in the management of necrotizing soft tissue infections (NSTI).

Author(s):  
Karen Decock ◽  
Frans Vanwingh
Toxins ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 332 ◽  
Author(s):  
Patience Shumba ◽  
Srikanth Mairpady Shambat ◽  
Nikolai Siemens

Necrotizing soft tissue infections (NSTIs) are critical clinical conditions characterized by extensive necrosis of any layer of the soft tissue and systemic toxicity. Group A streptococci (GAS) and Staphylococcus aureus are two major pathogens associated with monomicrobial NSTIs. In the tissue environment, both Gram-positive bacteria secrete a variety of molecules, including pore-forming exotoxins, superantigens, and proteases with cytolytic and immunomodulatory functions. The present review summarizes the current knowledge about streptococcal and staphylococcal toxins in NSTIs with a special focus on their contribution to disease progression, tissue pathology, and immune evasion strategies.


2017 ◽  
Vol 42 (1) ◽  
pp. 82-87 ◽  
Author(s):  
Myriam Martinez ◽  
Thomas Peponis ◽  
Aglaia Hage ◽  
Daniel D. Yeh ◽  
Haytham M. A. Kaafarani ◽  
...  

2018 ◽  
Vol 218 (1) ◽  
pp. 44-52 ◽  
Author(s):  
Anshu Babbar ◽  
Trond Bruun ◽  
Ole Hyldegaard ◽  
Michael Nekludov ◽  
Per Arnell ◽  
...  

2016 ◽  
Vol 81 (5) ◽  
pp. 921-924 ◽  
Author(s):  
Stefan Walter Leichtle ◽  
Lily Tung ◽  
Moazzam Khan ◽  
Kenji Inaba ◽  
Demetrios Demetriades

2017 ◽  
Vol 44 (6) ◽  
pp. 535-542
Author(s):  
António Pedro Pinto Ferreira ◽  
◽  
Sérgio Santos Vide ◽  
Tiago David Fonseca Fernandes ◽  
Pedro Miguel Barata de Silva Coelho ◽  
...  

2017 ◽  
Vol 220 ◽  
pp. 372-378 ◽  
Author(s):  
Angela M. Ingraham ◽  
Hee Soo Jung ◽  
Amy E. Liepert ◽  
Charles Warner-Hillard ◽  
Caprice C. Greenberg ◽  
...  

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