The Effect in the Acid-Base Status, Electrolyte Levels and Anion-Gap Following Fluid Resuscitation with Normal Saline, Lactated Ringers and Isotonic Electrolyte Solution Fluids Among Pediatric Patients

Author(s):  
Mary Joy Torres
Author(s):  
Akshay Dafal ◽  
Sunil Kumar ◽  
Sachin Agrawal ◽  
Sourya Acharya ◽  
Apoorva Nirmal

Abstract Introduction Anion gap (AG) metabolic acidosis is common in critically ill patients. The relationship between initial AG at the time of admission to the medical intensive care unit (MICU) and mortality or length of stay is unclear. This study was undertaken to evaluate this relationship. Materials and Method We prospectively examined the acid–base status of 500 consecutive patients at the time of MICU admission and outcome was measured in terms of mortality, length of ICU stay, need of ventilator, and laboratory parameters. The patients were divided into four stages based on the severity of AG. Outcome based on the severity of AG was measured, and comparisons that adjusted for baseline characteristics were performed. Results This study showed that increased AG was associated with the higher mortality. Patients with the highest AG also had the longest length of stay in the MICU, and patients with normal acid–base status had the shortest ICU length of stays (p < 0.05). Conclusion A high AG at the time of admission to the MICU was associated with higher mortality and length of stays. Initial risk stratification based on AG and metabolic acidosis may help guide appropriate patient disposition (especially in patients without other definitive criteria for MICU admission) and assist with prognosis.


1989 ◽  
Vol 9 (4) ◽  
pp. 64-73
Author(s):  
A Lorenz

Despite current management, lactic acidosis continues to carry a high mortality because of the severity of the precipitating illness and the complications of lactic acidosis itself. Continuous nursing assessment of hemodynamic function, oxygenation and ventilation, and awareness of specific metabolic indicators (anion-gap, acid-base status) is mandatory. Early recognition of clinical situations likely to precede abnormal lactate accumulation can do much to improve the effectiveness of treatment.


1993 ◽  
Vol 21 (5) ◽  
pp. 808
Author(s):  
David Ernest ◽  
Robert G. Herkes ◽  
Raymond F. Raper

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