Interleukin-17 inhibitor therapy reduces arterial intima-media thickness in severe psoriasis

2021 ◽  
Author(s):  
Éva Anna Piros MD ◽  
Péter Holló
Keyword(s):  
Intima Media Thickness ◽  
Severe Psoriasis ◽  
Inhibitor Therapy ◽  
Interleukin 17 ◽  
Media Thickness ◽  
Arterial Intima

scholarly journals 047 Interleukin-17 inhibitor therapy reduces arterial intima-media thickness in severe psoriasis

2021 ◽  
Vol 141 (10) ◽  
pp. S156
Author(s):  
É.A. Piros ◽  
Á. Szabó ◽  
F. Rencz ◽  
V. Brodszky ◽  
K. Szalai ◽  
...  
Keyword(s):  
Intima Media Thickness ◽  
Severe Psoriasis ◽  
Inhibitor Therapy ◽  
Interleukin 17 ◽  
Media Thickness ◽  
Arterial Intima

scholarly journals Impact of Interleukin-17 Inhibitor Therapy on Arterial Intima-media Thickness among Severe Psoriatic Patients

Life ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 919
Author(s):  
Éva Anna Piros ◽  
Ákos Szabó ◽  
Fanni Rencz ◽  
Valentin Brodszky ◽  
Klára Szalai ◽  
...  
Keyword(s):  
Life Quality ◽  
Intima Media Thickness ◽  
Severity Index ◽  
Inhibitor Therapy ◽  
Interleukin 17 ◽  
Psoriasis Area Severity Index ◽  
Carotid Imt ◽  
Media Thickness ◽  
Arterial Intima ◽  
Eq Vas

Background: Psoriasis is frequently accompanied by cardiovascular diseases based on the shared immunopathogenic pathway. Authors determined the effect of interleukin (IL)-17 inhibitor therapy on arterial intima-media thickness (IMT) among severe psoriatic patients. Methods: Thirty-one severe psoriatic patients were enrolled. Twenty received secukinumab and 11 received ixekizumab. Before treatment initiation and after 6 months, the carotid-brachial-femoral IMT, the Psoriasis Area Severity Index (PASI), the Dermatology Life Quality of Index (DLQI) and the EuroQol Visual Analogue Scale (EQ VAS) were evaluated. Results: After 6 months, significant ameliorations were observed in PASI (p < 0.001) from 18 to 0, in DLQI (p < 0.001) from 17 to 0, in EQ VAS (p < 0.001) from 60 to 90, in right carotid IMT (p < 0.001) from 1.1 mm to 0.8 mm, in left carotid IMT (p < 0.001) from 1.1 mm to 0.7 mm, in right brachial IMT (p < 0.001) from 0.75 mm to 0.6 mm, in left brachial IMT (p < 0.001) from 0.8 mm to 0.5 mm, in right femoral IMT (p < 0.001) from 0.9 mm to 0.7 mm and in left femoral IMT (p < 0.001) from 0.8 mm to 0.7 mm. Conclusions: By reducing the inflammation of the vascular wall, anti-IL-17 therapy may have a beneficial long-term effect on cardiovascular complications of systemic inflammation.

scholarly journals Atherosclerosis in rheumatoid arthtritis: the role of high-resolution B mode ultrasound in the measurement of the arterial intima-media thickness

Reumatismo ◽  
2011 ◽  
Vol 59 (1) ◽  
Author(s):  
M. Carotti ◽  
F. Salaffi ◽  
M. Mangiacotti ◽  
A. Cerioni ◽  
G.M. Giuseppetti ◽  
...  
Keyword(s):  
High Resolution ◽  
Intima Media Thickness ◽  
Media Thickness ◽  
Arterial Intima

scholarly journals Endothelial Dysfunction and Increased Arterial Intima-Media Thickness in Children With Type 1 Diabetes

Circulation ◽  
2004 ◽  
Vol 109 (14) ◽  
pp. 1750-1755 ◽  
Author(s):  
Mikko J. Järvisalo ◽  
Maria Raitakari ◽  
Jyri O. Toikka ◽  
Anne Putto-Laurila ◽  
Riikka Rontu ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Intima Media Thickness ◽  
Media Thickness ◽  
Arterial Intima

Arterial Intima-Media Thickness in 13-Year-Old Adolescents and Previous Antichlamydial Antimicrobial Use: A Retrospective Follow-up Study

PEDIATRICS ◽  
2008 ◽  
Vol 122 (3) ◽  
pp. e675-e681 ◽  
Author(s):  
I. Volanen ◽  
K. Kallio ◽  
M. Saarinen ◽  
M. J. Jarvisalo ◽  
R. Vainionpaa ◽  
...  
Keyword(s):  
Intima Media Thickness ◽  
Antimicrobial Use ◽  
Follow Up Study ◽  
Media Thickness ◽  
Arterial Intima

Investigation of the arterial intima-media thickness in Behcet’s disease patients without vascular complaints

Vascular ◽  
2017 ◽  
Vol 26 (4) ◽  
pp. 356-361
Author(s):  
Nazım Kankilic ◽  
Aydın Aslan ◽  
Oguz Karahan ◽  
Sinan Demirtas ◽  
Ahmet Caliskan ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Intima Media Thickness ◽  
Vascular Involvement ◽  
Behcet's Disease ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Media Thickness ◽  
Arterial Intima

Objectives Behcet’s disease is a multisystemic, inflammatory disease. Various factors have been implicated in the disease, including genetics, infections, immunoglobulins, immune complexes, antibodies, and oxidative stress. However, the underlying etiopathogenesis remains unclear. Behcet’s disease can occur with or without vascular involvement. This prospective study investigated the relationship between the intima-media thickness of the major arteries, in addition to other factors affecting the disease process, in Behcet’s disease without vascular involvement. Methods Twenty-four patients (average age: 38.50 ± 10.931) without vascular involvement or any vascular complaints who were diagnosed with Behcet’s disease were included in the study. Sixteen healthy subjects (average age: 39.75 ± 7.793) were included as a control group. Demographic information and medical histories were recorded, and routine blood tests were performed in both groups. The intima-media thickness of the subclavian, axillary, femoral, and carotid arteries of all the participants were recorded using Doppler ultrasonography. The data were then subjected to intergroup statistical and correlation analyses. Results There were no significant differences between the arterial intima-media thickness values of the Behcet’s disease patients and those of the control group ( p > 0.05). However, there was a significant difference between the neutrophil–lymphocyte ratio ( p = 0.004), low-density lipoprotein ( p = 0.007), and triglyceride ( p = 0042) levels of the two groups. Significant correlations were found between intima-media thickness and neutrophil–lymphocyte ratio levels ( p = 0.012) and the disease duration ( p = 0.030). There was also a significant correlation between the intima-media thickness of the femoral artery and disease duration ( p = 0.014). Conclusions The results showed that the duration of illness had a significant effect on arterial intima-media thickness in Behcet’s disease. Blood neutrophil–lymphocyte ratio levels were also associated with increased intima-media thickness.

Arterial intima-media thickness: site-specific associations with HRT and habitual exercise

2002 ◽  
Vol 283 (4) ◽  
pp. H1409-H1417 ◽  
Author(s):  
Kerrie L. Moreau ◽  
Anthony J. Donato ◽  
Douglas R. Seals ◽  
Frank A. Dinenno ◽  
Sharon D. Blackett ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Hormone Replacement ◽  
Intima Media Thickness ◽  
Group Differences ◽  
Significant Group ◽  
Site Specific ◽  
Carotid Imt ◽  
Media Thickness ◽  
Habitual Exercise ◽  
Arterial Intima

We determined the site-specific relations of hormone replacement therapy (HRT) and habitual exercise status with intima-media thickness (IMT) in both elastic (carotid) and muscular (femoral) arteries in 77 healthy postmenopausal women: 43 women were sedentary (20 no-HRT and 23 HRT users) and 34 women were endurance trained (14 no-HRT and 20 HRT users). Femoral IMT was not different among the sedentary HRT and endurance-trained no-HRT and HRT groups, but was lower ( P < 0.005) in these three groups than in the sedentary no-HRT women. There were no significant group differences in carotid IMT. However, in older women (≥65 yrs) carotid IMT was smaller ( P < 0.05) in HRT compared with no-HRT women. We conclude that both endurance training and HRT status are independently associated with a smaller IMT and these effects are evident primarily in muscular arteries. These results suggest that HRT and habitual exercise may protect postmenopausal women against cardiovascular disease through influences on IMT. The site-specific relations may be due to a greater number of smooth muscle cells and plasticity of muscular arteries compared with elastic arteries and/or differences in heterogeneous influences such as metabolic requirements and hydrostatic pressures.

scholarly journals Decrease in Carotid Intima-Media Thickness after 1-Year Therapy with Etidronate for Osteopenia Associated with Type 2 Diabetes1

2000 ◽  
Vol 85 (8) ◽  
pp. 2793-2796 ◽  
Author(s):  
Hiroyuki Koshiyama ◽  
Yoshio Nakamura ◽  
Satsuki Tanaka ◽  
Jun Minamikawa
Keyword(s):  
Type 2 Diabetes ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Experimental Animals ◽  
Media Thickness ◽  
Cyclical Etidronate ◽  
Arterial Intima ◽  
Carotid Arterial

It has been suggested that bisphosphonates may have some antiatherogenic actions in experimental animals or in vitro, but their effects on the atherogenic process in humans has not been reported. In the present study the effect of etidronate treatment on carotid arterial intima-media thickness was prospectively examined in 57 subjects with type 2 diabetes associated with osteopenia. After 1 yr of therapy with cyclical etidronate (200 mg/day for 2 weeks every 3 months), intima-media thickness showed a decrease (mean ± se, −0.038 ± 0.011 mm), which was significantly different from a change in 57 control subjects (0.023 ± 0.015 mm; P &lt; 0.005). Cardiovascular parameters were not changed after etidronate treatment. These findings suggest that etidronate in clinical dosage may have an antiatherogenic action, at least in type 2 diabetes, although its mechanisms remain to be elucidated.

Increased arterial intima-media thickness by B-M mode echodoppler ultrasonography in acromegaly

2001 ◽  
Vol 54 (4) ◽  
pp. 515-524 ◽  
Author(s):  
Annamaria Colao ◽  
Stefano Spiezia ◽  
Gaetana Cerbone ◽  
Rosario Pivonello ◽  
Paolo Marzullo ◽  
...  
Keyword(s):  
Intima Media Thickness ◽  
Media Thickness ◽  
Arterial Intima
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