Impact of Interleukin-17 Inhibitor Therapy on Arterial Intima-media Thickness among Severe Psoriatic Patients

Background: Psoriasis is frequently accompanied by cardiovascular diseases based on the shared immunopathogenic pathway. Authors determined the effect of interleukin (IL)-17 inhibitor therapy on arterial intima-media thickness (IMT) among severe psoriatic patients. Methods: Thirty-one severe psoriatic patients were enrolled. Twenty received secukinumab and 11 received ixekizumab. Before treatment initiation and after 6 months, the carotid-brachial-femoral IMT, the Psoriasis Area Severity Index (PASI), the Dermatology Life Quality of Index (DLQI) and the EuroQol Visual Analogue Scale (EQ VAS) were evaluated. Results: After 6 months, significant ameliorations were observed in PASI (p < 0.001) from 18 to 0, in DLQI (p < 0.001) from 17 to 0, in EQ VAS (p < 0.001) from 60 to 90, in right carotid IMT (p < 0.001) from 1.1 mm to 0.8 mm, in left carotid IMT (p < 0.001) from 1.1 mm to 0.7 mm, in right brachial IMT (p < 0.001) from 0.75 mm to 0.6 mm, in left brachial IMT (p < 0.001) from 0.8 mm to 0.5 mm, in right femoral IMT (p < 0.001) from 0.9 mm to 0.7 mm and in left femoral IMT (p < 0.001) from 0.8 mm to 0.7 mm. Conclusions: By reducing the inflammation of the vascular wall, anti-IL-17 therapy may have a beneficial long-term effect on cardiovascular complications of systemic inflammation.

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Interleukin-17 inhibitor therapy reduces arterial intima-media thickness in severe psoriasis

10.26226/morressier.61081ff8bc981037240fe3b8 ◽

2021 ◽

Author(s):

Éva Anna Piros MD ◽

Péter Holló

Keyword(s):

Intima Media Thickness ◽

Severe Psoriasis ◽

Inhibitor Therapy ◽

Interleukin 17 ◽

Media Thickness ◽

Arterial Intima

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047 Interleukin-17 inhibitor therapy reduces arterial intima-media thickness in severe psoriasis

Journal of Investigative Dermatology ◽

10.1016/j.jid.2021.08.049 ◽

2021 ◽

Vol 141 (10) ◽

pp. S156

Author(s):

É.A. Piros ◽

Á. Szabó ◽

F. Rencz ◽

V. Brodszky ◽

K. Szalai ◽

...

Keyword(s):

Intima Media Thickness ◽

Severe Psoriasis ◽

Inhibitor Therapy ◽

Interleukin 17 ◽

Media Thickness ◽

Arterial Intima

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Arterial intima-media thickness: site-specific associations with HRT and habitual exercise

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00035.2002 ◽

2002 ◽

Vol 283 (4) ◽

pp. H1409-H1417 ◽

Cited By ~ 46

Author(s):

Kerrie L. Moreau ◽

Anthony J. Donato ◽

Douglas R. Seals ◽

Frank A. Dinenno ◽

Sharon D. Blackett ◽

...

Keyword(s):

Postmenopausal Women ◽

Hormone Replacement ◽

Intima Media Thickness ◽

Group Differences ◽

Significant Group ◽

Site Specific ◽

Carotid Imt ◽

Media Thickness ◽

Habitual Exercise ◽

Arterial Intima

We determined the site-specific relations of hormone replacement therapy (HRT) and habitual exercise status with intima-media thickness (IMT) in both elastic (carotid) and muscular (femoral) arteries in 77 healthy postmenopausal women: 43 women were sedentary (20 no-HRT and 23 HRT users) and 34 women were endurance trained (14 no-HRT and 20 HRT users). Femoral IMT was not different among the sedentary HRT and endurance-trained no-HRT and HRT groups, but was lower ( P < 0.005) in these three groups than in the sedentary no-HRT women. There were no significant group differences in carotid IMT. However, in older women (≥65 yrs) carotid IMT was smaller ( P < 0.05) in HRT compared with no-HRT women. We conclude that both endurance training and HRT status are independently associated with a smaller IMT and these effects are evident primarily in muscular arteries. These results suggest that HRT and habitual exercise may protect postmenopausal women against cardiovascular disease through influences on IMT. The site-specific relations may be due to a greater number of smooth muscle cells and plasticity of muscular arteries compared with elastic arteries and/or differences in heterogeneous influences such as metabolic requirements and hydrostatic pressures.

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Nonclassical Monocytes (CD14dimCD16+) Are Associated With Carotid Intima-Media Thickness Progression for Men but Not Women

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvbaha.120.315886 ◽

2021 ◽

Author(s):

Matthew J. Feinstein ◽

Margaret F. Doyle ◽

James H. Stein ◽

Colleen M. Sitlani ◽

Alison E. Fohner ◽

...

Keyword(s):

Mononuclear Cells ◽

Disease Onset ◽

Intima Media Thickness ◽

Interleukin 17 ◽

T Helper ◽

Monocyte Subsets ◽

Peripheral Blood Mononuclear ◽

Carotid Imt ◽

Media Thickness ◽

Classical Monocytes

Objective: Few studies of population-based cohorts have investigated prospective associations of lymphoid and myeloid cell subsets in cardiovascular disease onset and progression. The purpose of this analysis was to determine associations of prespecified myeloid and lymphoid lineage cell subsets with common carotid artery intima-media thickness (IMT) progression. Approach and Results: We performed a prospective case-cohort study of 1195 participants from the Multi-Ethnic Study of Atherosclerosis who had peripheral blood mononuclear cells stored from the baseline examination. Key exposure variables were prespecified subsets of lymphoid and myeloid lineage immune cells, phenotyped by multicolor flow cytometry. The primary outcome was progression from baseline (Exam 1) to year 10 (Exam 5) in common carotid IMT. Higher proportions of nonclassical monocytes (CD14dimCD16++) were significantly associated with IMT progression over 10 years, but classical monocytes (CD14++CD16−), CD4+CD28− T cells, and T helper cells producing IL-17 (interleukin 17; T helper 17 cells) were not associated with significant changes in IMT over 10 years. There were significant interactions between monocyte subsets and sex with respect to IMT progression: in sex-stratified analyses, nonclassical monocytes were associated with significant IMT progression and classical monocytes were associated with significant IMT regression for men, whereas there were no significant associations of monocyte subsets with IMT change for women. Conclusions: Nonclassical monocytes were associated with progression of carotid IMT. There were significant sex differences in associations of monocyte subsets with IMT progression: for men, nonclassical monocytes were associated with IMT progression and classical monocytes were associated with regression, whereas these associations were null for women.

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Abstract P218: Carotid Intima-media Thickness and Incident End-stage Renal Disease: The Atherosclerosis Risk in Communities Study

Circulation ◽

10.1161/circ.133.suppl_1.p218 ◽

2016 ◽

Vol 133 (suppl_1) ◽

Author(s):

Yuanjie Pang ◽

Yingying Sang ◽

Shoshana Ballew ◽

Morgan Grams ◽

Gerardo Heiss ◽

...

Keyword(s):

Renal Disease ◽

Kidney Function ◽

End Stage Renal Disease ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Carotid Imt ◽

Media Thickness ◽

Hazard Ratios ◽

Stage Renal Disease ◽

End Stage

Introduction: Carotid intima-media thickness (IMT) has been reported to predict kidney function decline. However, whether carotid IMT is associated with a hard kidney endpoint, end-stage renal disease (ESRD), has not been investigated. Hypothesis: We assessed the hypothesis that increased carotid IMT is associated with ESRD risk. Methods: We studied 13,197 ARIC participants at visit 1 (1987-1989) without history of cardiovascular disease including coronary heart disease, stroke and heart failure and assessed whether carotid IMT measured by B-mode ultrasound is associated with ESRD risk using Cox proportional-hazards models. Regarding carotid IMT parameters, we investigated the mean and maximum values of overall and segment-specific (common, bifurcation and internal carotid arteries) measurements. Results: Mean age was 54.0 (SD 5.7) years, and there were 3,373 (25.6%) blacks and 7,370 (55.8%) women. During a median follow-up of 22.7 years, 433 participants developed ESRD (1.4/1,000 person-years). After adjusting for shared risk factors for atherosclerosis and kidney disease, including baseline kidney function, carotid IMT was significantly associated with ESRD risk (hazard ratios between quartiles 4 and 1, 1.43 [95%CI: 1.01-2.04] for overall mean IMT and 1.73 [95%CI: 1.22-2.44] for overall maximum IMT). The associations were largely consistent in demographic and clinical subgroups. When we explored segment-specific IMTs, the associations with ESRD were most robust for bifurcation carotid. The adjusted hazard ratios between quartiles 4 and 1 were 1.48 (95%CI: 1.04-2.11) for mean bifurcation IMT and 1.42 (95%CI: 0.99-2.03) for maximum bifurcation IMT. Conclusions: Carotid IMT was independently associated with incident ESRD in the general population. Our findings suggest the shared etiology between atherosclerosis and ESRD and highlight the importance of monitoring kidney function over time in individuals with subclinical atherosclerosis.

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Abstract 950: Should We Measure Intima Media Thickness In Patients With Peripheral Arterial Disease?

Circulation ◽

10.1161/circ.118.suppl_18.s_634-b ◽

2008 ◽

Vol 118 (suppl_18) ◽

Author(s):

Christine Espinola-Klein ◽

Hans J Rupprecht ◽

Christoph Bickel ◽

Karl Lackner ◽

Savvas Savvidis ◽

...

Keyword(s):

Peripheral Arterial Disease ◽

Cardiovascular Mortality ◽

Independent Predictor ◽

Intima Media Thickness ◽

Arterial Disease ◽

Prognostic Impact ◽

Carotid Imt ◽

Coronary Syndrome ◽

Media Thickness ◽

Peripheral Arterial

Background: Carotid intima-media thickness (IMT) is a marker of early atherosclerosis. Patients with peripheral arterial disease (PAD) have advanced atherosclerosis and a high cardiovascular event rate. The aim of this study was to evaluate, whether measurement of carotid IMT adds prognostic information in PAD patients. Methods: We included 165 patients (mean age 64.5 ± 9 years, 71.5% men) with PAD. In all patients IMT was measured at both common carotid arteries and the mean IMT was used for further evaluation. Carotid IMT of more than 0.9 mm was defined as thickened. After a median follow-up of 6.5 years in total 33 patients (20%) died from cardiovascular causes. Results: Mean IMT was 0.75 ± 0.19 mm and in 30 patients (18.2%) an IMT ≥ 0.9 mm could be detected. Cardiovascular mortality was significantly higher in patients with PAD and IMT ≥ 0.9 mm than in patients with IMT ≥ 0.9 mm (IMT ≥ 0.9 mm = 40.0 % versus IMT < 0.9 mm = 15.6 %; P=0.002, figure ). In a fully adjusted Cox regression analysis (adjusted for age, sex, diabetes, hypertension, high density lipoprotein cholesterol, smoking, body mass index and acute coronary syndrome) a carotid IMT ≥ 0.9 mm could not be identified as an independent predictor for cardiovascular death (Hazard Ratio (95% Confidence Interval) = 2.0 (0.9 – 4.2), P=0.09). Conclusion: Patients with PAD and a carotid IMT ≥ 0.9 mm had a higher cardiovascular mortality than patients with normal IMT. But an increased carotid IMT could not be identified as independent predictor for cardiovascular mortality. Therefore it should be discussed whether IMT measurement adds prognostic impact in patients with PAD. Survival in Accordance to Carotid IMT

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Atherosclerosis in rheumatoid arthtritis: the role of high-resolution B mode ultrasound in the measurement of the arterial intima-media thickness

Reumatismo ◽

10.4081/reumatismo.2007.38 ◽

2011 ◽

Vol 59 (1) ◽

Author(s):

M. Carotti ◽

F. Salaffi ◽

M. Mangiacotti ◽

A. Cerioni ◽

G.M. Giuseppetti ◽

...

Keyword(s):

High Resolution ◽

Intima Media Thickness ◽

Media Thickness ◽

Arterial Intima

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Endothelial Dysfunction and Increased Arterial Intima-Media Thickness in Children With Type 1 Diabetes

Circulation ◽

10.1161/01.cir.0000124725.46165.2c ◽

2004 ◽

Vol 109 (14) ◽

pp. 1750-1755 ◽

Cited By ~ 280

Author(s):

Mikko J. Järvisalo ◽

Maria Raitakari ◽

Jyri O. Toikka ◽

Anne Putto-Laurila ◽

Riikka Rontu ◽

...

Keyword(s):

Type 1 Diabetes ◽

Endothelial Dysfunction ◽

Intima Media Thickness ◽

Media Thickness ◽

Arterial Intima

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Common femoral artery intima-media thickness as marker for cardiovascular disease in asymptomatic adults

VASA ◽

10.1024/0301-1526.38.2.147 ◽

2009 ◽

Vol 38 (2) ◽

pp. 147-154 ◽

Cited By ~ 7

Author(s):

Giannoukas ◽

Antoniou ◽

Saleptsis ◽

Baros ◽

Griffin ◽

...

Keyword(s):

Cardiovascular Disease ◽

Risk Score ◽

Density Lipoprotein ◽

Intima Media Thickness ◽

Common Femoral Artery ◽

Carotid Intima Media Thickness ◽

Carotid Imt ◽

Media Thickness ◽

Similar Correlation ◽

The Common

Background: The common carotid intima-media thickness (IMT) is considered as a marker of cardiovascular disease, while the value of the common femoral IMT is not well defined. The aim of the present study was to investigate the value of common femoral IMT alone or in combination with the common carotid IMT as a marker of cardiovascular disease in asymptomatic adults. Patients and Methods: Eighty-three individuals with no history of cardiovascular disease were subjected to IMT measurement of both common carotid and common femoral arteries with high-resolution ultrasonography. The Framingham Heart Study (FHS) risk score was calculated for each subject (according to gender) and was correlated with the carotid IMT, femoral IMT, and the combined IMT measured at both arterial sites. Results: The carotid and femoral IMT separately and in combination were found to be correlated with the FHS risk score, calculated based on either the total cholesterol or low density lipoprotein plasma levels (carotid IMT: r = 0.28, p = 0.035, and r = 0.35, p = 0.007, respectively, femoral IMT: r = 0.38, p = 0.003, and r = 0.43, p = 0.001, respectively, carotid-femoral IMT: r = 0.37, p = 0.005, and r = 0.46, p = 0.0001, respectively). In addition, femoral IMT was found to be correlated with the carotid IMT (r = 0.41, p = 0.001). Conclusions: Common carotid and common femoral IMT showed similar correlation with the FHS risk score. Additionally, the combination of IMT from both arterial sites was found to have similar correlation with the FHS risk score to carotid IMT alone.

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