Plasmacytoid dendritic cells sense SARS-CoV-2 through TLR2-IL6 and TLR7-INFα pathways that protect epithelial cells from infection

2021 ◽  
Author(s):  
Renee van der Sluis
Keyword(s):  
Dendritic Cells ◽  
Epithelial Cells ◽  
Plasmacytoid Dendritic Cells

scholarly journals Airway epithelial cells prime plasmacytoid dendritic cells to respond to pathogens via secretion of growth factors

2018 ◽  
Vol 12 (1) ◽  
pp. 77-84 ◽  
Author(s):  
Farah Rahmatpanah ◽  
Sudhanshu Agrawal ◽  
Natasha Jaiswal ◽  
Hannah M. Nguyen ◽  
Michael McClelland ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Growth Factors ◽  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Airway Epithelial

scholarly journals Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections

2020 ◽  
Author(s):  
Alan Bénard ◽  
Anne Jacobsen ◽  
Maximilian Brunner ◽  
Christian Krautz ◽  
Bettina Klösch ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Epithelial Cells ◽  
Severe Acute Respiratory Syndrome ◽  
Therapeutic Target ◽  
Predictive Marker ◽  
Plasmacytoid Dendritic Cells ◽  
Potential Therapeutic Target ◽  
Health Threat ◽  
Interleukin 3 ◽  
Disease Marker

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a worldwide health threat. Here, we report that low plasma interleukin-3 (IL-3) levels were associated with increased severity and mortality during SARS-CoV-2 infections. IL-3 promoted the recruitment of antiviral circulating plasmacytoid dendritic cells (pDCs) into the airways by stimulating CXCL12 secretion from pulmonary CD123+ epithelial cells. This study identifies IL-3 as a predictive disease marker and potential therapeutic target for SARS-CoV-2 infections.

scholarly journals Correction: Airway epithelial cells prime plasmacytoid dendritic cells to respond to pathogens via secretion of growth factors

2019 ◽  
Vol 12 (3) ◽  
pp. 841-841
Author(s):  
Farah Rahmatpanah ◽  
Sudhanshu Agrawal ◽  
Natasha Jaiswal ◽  
Hannah M. Nguyen ◽  
Michael McClelland ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Growth Factors ◽  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Airway Epithelial

scholarly journals Human plasmacytoid dendritic cells acquire phagocytic capacity by TLR9 ligation in the presence of soluble factors produced by renal epithelial cells

2018 ◽  
Vol 93 (2) ◽  
pp. 355-364 ◽  
Author(s):  
Jurjen M. Ruben ◽  
Gina Stella García-Romo ◽  
Eytan Breman ◽  
Sandra van der Kooij ◽  
Anke Redeker ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Epithelial Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Phagocytic Capacity ◽  
Soluble Factors ◽  
Renal Epithelial Cells

scholarly journals Epithelial Cells Activate Plasmacytoid Dendritic Cells Improving Their Anti-HIV Activity

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e28709 ◽  
Author(s):  
Christian Rodriguez Rodrigues ◽  
Mercedes Cabrini ◽  
Federico Remes Lenicov ◽  
Juan Sabatté ◽  
Ana Ceballos ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Epithelial Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Anti Hiv

scholarly journals Plasmacytoid dendritic cells produce type I interferon and reduce viral replication in airway epithelial cells after SARS-CoV-2 infection

2021 ◽  
Author(s):  
Luisa Cervantes-Barragan ◽  
Abigail Vanderheiden ◽  
Charlotte J Royer ◽  
Meredith E Davis-Gardner ◽  
Philipp Ralfs ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Epithelial Cells ◽  
Viral Replication ◽  
Immune Cell ◽  
Type I Interferon ◽  
Airway Epithelial Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Type I ◽  
Airway Epithelial ◽  
Type I Ifn

Infection with SARS-CoV-2 has caused a pandemic of unprecedented dimensions. SARS-CoV-2 infects airway and lung cells causing viral pneumonia. The importance of type I interferon (IFN) production for the control of SARS-CoV-2 infection is highlighted by the increased severity of COVID-19 in patients with inborn errors of type I IFN response or auto-antibodies against IFN-α. Plasmacytoid dendritic cells (pDCs) are a unique immune cell population specialized in recognizing and controlling viral infections through the production of high concentrations of type I IFN. In this study, we isolated pDCs from healthy donors and showed that pDCs are able to recognize SARS-CoV-2 and rapidly produce large amounts of type I IFN. Sensing of SARS-CoV-2 by pDCs was independent of viral replication since pDCs were also able to recognize UV-inactivated SARS-CoV-2 and produce type I IFN. Transcriptional profiling of SARS-CoV-2 and UV-SARS-CoV-2 stimulated pDCs also showed a rapid type I and III IFN response as well as induction of several chemokines, and the induction of apoptosis in pDCs. Moreover, we modeled SARS-CoV-2 infection in the lung using primary human airway epithelial cells (pHAEs) and showed that co-culture of pDCs with SARS-CoV-2 infected pHAEs induces an antiviral response and upregulation of antigen presentation in pHAE cells. Importantly, the presence of pDCs in the co-culture results in control of SARS-CoV-2 replication in pHAEs. Our study identifies pDCs as one of the key cells that can recognize SARS-CoV-2 infection, produce type I and III IFN and control viral replication in infected cells.

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