scholarly journals Benign Metastatic Leiomyoma: Unusual Heart Location

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Elaouni S ◽  
◽  
Jebli S ◽  
Sassi S ◽  
Bernoussi Z ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Progesterone Receptors ◽  
Smooth Muscle Tumor ◽  
Cardiac Metastasis ◽  
Cardiac Tumors ◽  
Clinical Settings ◽  
Benign Metastasizing Leiomyoma ◽  
First Case ◽  
History Of ◽  
Metastasizing Leiomyoma

Cardiac smooth muscle tumors are rare; three different clinical settings for these tumors have been reported, including benign metastasizing leiomyoma from the uterus, primary cardiac leiomyoma and leiomyosarcoma, and intravenous cardiac extension of pelvic leiomyoma, which is the most common. We present a case of a 56-year-old woman with a benign metastasizing leiomyoma to the heart without associated pulmonary localization 15 years after endoscopic vaginal myomectomy of polymyomatous uterus. Immunohistochemical stains for H-Caldesmon, Desmin, and estrogen, progesterone receptors were positive, indicating a smooth muscle tumor of uterine origin. To our knowledge, this is only the fifth reported case of benign metastasizing leiomyoma to the heart with histological proof and the first case of earlier onset cardiac metastasis without pulmonary metastasis localization. It illustrates that benign metastasizing leiomyoma should be included in the differential diagnosis of cardiac tumors in patients with a history of surgery uterine leiomyoma perfectly benign.

scholarly journals Benign Metastasizing Leiomyoma: A Rare Type of Lung Metastases—Two Case Reports and Review of the Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Rokana Taftaf ◽  
Sandra Starnes ◽  
Jiang Wang ◽  
Ralph Shipley ◽  
Tariq Namad ◽  
...  
Keyword(s):  
Uterine Leiomyoma ◽  
Progesterone Receptors ◽  
Pulmonary Nodules ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Benign Metastasizing Leiomyoma ◽  
Ct Guided ◽  
First Case ◽  
History Of ◽  
Metastasizing Leiomyoma

Benign metastasizing leiomyoma (BML) is a rare disease that usually occurs in women of reproductive age. They typically have history of uterine leiomyoma treated with hysterectomy. BML can metastasize to distant organs, with the lung being the most common organ. We report two patients who presented with benign metastasizing leiomyoma to the lung. Our first case was a fifty-two-year-old female who presented with multiple lung masses, with a past medical history of uterine leiomyoma who underwent hysterectomy 17 years ago. A CT-guided biopsy showed benign appearing spindle cells and pathology confirmed her diagnosis with additional positive estrogen/progesterone receptor stains. Our second case was a fifty-six-year-old female who presented with multiple cavitary pulmonary nodules. She subsequently underwent a video-assisted thoracoscopic surgery (VATS) with wedge resection of one of the nodules. Pathology confirmed the diagnosis based on morphology and immunohistochemical staining strongly positive for estrogen/progesterone receptors. Benign metastasizing leiomyoma is a rare condition which may affect women of reproductive age. This should be considered in the differential in patients who present with multiple pulmonary nodules, especially with a history of uterine leiomyoma. Additional stains, such as estrogen/progesterone receptors, may need to be done to confirm the diagnosis.

scholarly journals An Unusual Cause of Pulmonary Nodules in the Emergency Department

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Ryan Yu ◽  
Melanie Ferri
Keyword(s):  
Emergency Department ◽  
Smooth Muscle ◽  
Clinical Presentation ◽  
Pulmonary Nodules ◽  
Pleuritic Chest Pain ◽  
Benign Metastasizing Leiomyoma ◽  
Spindle Cells ◽  
Smooth Muscle Tumors ◽  
Metastasizing Leiomyoma ◽  
Tomography Scan

We report a 51-year-old woman who presented to the emergency department with left-sided pleuritic chest pain 2 weeks after subtotal hysterectomy and bilateral salpingo-oophorectomy for a leiomyomatous uterus. Computed tomography scan of the chest revealed bilateral pulmonary nodules. Biopsy showed cytologically bland spindle cells without overt malignant features. Immunohistochemistry confirmed smooth muscle phenotype, in keeping with a clinicopathologic diagnosis of benign metastasizing leiomyoma (BML). BML does not frequently come to the attention of the emergency physician because it is rare and usually asymptomatic. When symptomatic, its clinical presentation depends on the site(s) of metastasis, number, and size of the smooth muscle tumors. Emergent presentations of BML are reviewed.

scholarly journals Saccharomyces cerevisiaeLaryngitis and Oral Lesions in a Patient with Laryngeal Carcinoma

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Jumanah N. Algazaq ◽  
Kevan Akrami ◽  
Fernando Martinez ◽  
Allen McCutchan ◽  
Ajay R. Bharti
Keyword(s):  
Laryngeal Carcinoma ◽  
Opportunistic Infections ◽  
Nutritional Supplement ◽  
Clinical Settings ◽  
Oral Lesions ◽  
Health Food ◽  
First Case ◽  
Antibiotic Associated Diarrhea ◽  
History Of ◽  
Tract Infections

Saccharomyces cerevisiaeis increasingly being promoted as a nutritional supplement by health food enthusiasts and is also recommended as prophylaxis against antibiotic-associated diarrhea. However, severe opportunistic infections due toS. cerevisiaehave been reported in patients with chronic disease, cancer, and immunosuppression. Fungemia, endocarditis, pneumonia, peritonitis, urinary tract infections, skin infections, and esophagitis have been described. It is important to consider infections due toS. cerevisiaein appropriate clinical settings. Here, we describe the first case ofS. cerevisiaelaryngitis in a patient with a history of laryngeal carcinoma who also had oral lesions.

Perivascular Leiomyomatosis: A Unique Case Report

2018 ◽  
Vol 26 (7) ◽  
pp. 676-679 ◽  
Author(s):  
Scott Wolfe ◽  
James Sullivan ◽  
Leonard Kahn
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Outer Surface ◽  
Muscle Layer ◽  
Growth Patterns ◽  
Unique Case ◽  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma ◽  
Multiple Nodules

There are 3 histologically benign smooth muscle neoplasms that have unusual growth patterns. These include intravascular leiomyomatosis, benign metastasizing leiomyoma, and leiomyomatosis peritonealis desseminata. We report a unique case of perivascular leiomyomatosis. The tumor showed multiple nodules of benign smooth muscle with some of the nodules closely associated with the periphery of the medial muscle layer of venous channels. All the neoplastic nodules were located on the outer surface of venous channels, thus precluding a diagnosis of intravascular leiomyomatosis. To the best of our knowledge, this is the first documentation of such an entity.

scholarly journals A Disorder Easy to be Misdiagnosed--benign Metastasizing Uterine Leiomyoma with Multiple Metastasis to Lungs and Pelvic Lymph Nodes Simultaneously and Literature Review

2021 ◽  
Author(s):  
tong tong ◽  
Qiong Fan ◽  
Yudong Wang ◽  
Yuhong Li
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Skeletal Muscles ◽  
Left Renal Vein ◽  
Uterine Sarcoma ◽  
Bilateral Oophorectomy ◽  
Benign Metastasizing Leiomyoma ◽  
History Of ◽  
Benign Nature ◽  
Metastasizing Leiomyoma

Abstract Background: Benign metastasizing leiomyoma (BML) is a rare disease that is usually seen in females of reproductive or premenopausal age with a previous surgery history of uterine myomectomy or hysterectomy. The most common sites of metastases are pulmonary metastases, and other sites include heart, bones, liver, lymph nodes, skin, bladder, esophagus, skeletal muscles, and central nervous system. Here we report a case of 50-year-old women with history of hysterectomy whom was first suspect uterine sarcoma but finally confirmed BML with lung and lymph node metastases at the same time and discuss the treatment and prognosis of BML. Case presentation: A 50-year-old women who have a history of abdominal total hysterectomy presented with mild but persistent abdominal pain for over 3 months. She was suspected uterine sarcoma before surgery and laparoscopic extensive debulking surgery including bilateral oophorectomy, pelvic and para-aortic lymph node dissection to the level of the left renal vein, and right inguinal lymph nodes dissection trans-cutaneously were done. Pathology after surgery confirmed benign leiomyoma and she was diagnosed BML. No medicine was given after the surgery and now the follow up is of no significance. Conclusions: Benign metastasizing leiomyoma (BML) is a rare disorder in which histologically benign smooth muscle tumor metastasize to extra-uterine sites. Metastases are commonly seen in the lung, liver, lymph nodes, skin, bladder, esophagus, skeletal muscles, et al. BML is usually misdiagnosed as malignant tumor before surgery until pathology confirmed the benign nature. The treatment is controversial and undetermined. The prognosis is usually favorable because of its benign nature.

scholarly journals Primary Intraosseous Smooth Muscle Tumor of Uncertain Malignant Potential: Original Report and Molecular Characterization

Rare Tumors ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 155-158 ◽  
Author(s):  
Lauren Kropp ◽  
Gene P. Siegal ◽  
Garrett M. Frampton ◽  
Michael G. Rodriguez ◽  
Svetlana McKee ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Molecular Characterization ◽  
Smooth Muscle Tumor ◽  
Malignant Potential ◽  
Uncertain Malignant Potential ◽  
First Case ◽  
Chromosome 12P ◽  
Life Threatening ◽  
Original Report ◽  
Muscle Tumor

We report the first case of primary intraosseous smooth muscle tumor of uncertain malignant potential (STUMP) which is analogous to borderline malignant uterine smooth muscle tumors so designated. The tumor presented in the femur of an otherwise healthy 30-year-old woman. Over a 3-year period, the patient underwent 11 biopsies or resections and 2 cytologic procedures. Multiple pathologists reviewed the histologic material including musculoskeletal pathologists but could not reach a definitive diagnosis. However, metastases eventually developed and were rapidly progressive and responsive to gemcitabine and docetaxel. Molecular characterization and ultrastructural analysis was consistent with smooth muscle origin, and amplification of unmutated chromosome 12p and 12q segments appears to be the major genomic driver of this tumor. Primary intraosseous STUMP is thought to be genetically related to leiomyosarcoma of bone, but likely representing an earlier stage of carcinogenesis. Wide excision and aggressive follow-up is warranted for this potentially life-threatening neoplasm.

scholarly journals Benign Metastasizing Leiomyoma to the Lung and Spine: A Case Report and Literature Review

2019 ◽  
Vol 12 (1) ◽  
pp. 218-223 ◽  
Author(s):  
Emily Barber ◽  
Ann Eapen ◽  
Rita Mehta ◽  
Erin Lin ◽  
Karen Lane ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Postmenopausal Woman ◽  
Hormonal Treatment ◽  
Current Management ◽  
Benign Metastasizing Leiomyoma ◽  
Clinical Challenge ◽  
Management Plans ◽  
Metastasizing Leiomyoma ◽  
Molecular Patterns

Benign metastasizing leiomyomas (BML) represent a rare phenomenon consisting of the extra-uterine spread of smooth muscle cells with similar histological, immunological, and molecular patterns to those of benign uterine leiomyomas. They are considered benign based off their low mitotic activity, lack of anaplasia or necrosis, and limited vascularization. This condition represents an interesting diagnostic and treatment challenge based on their rarity and indolent nature. Our case represents a unique finding of BML in the thoracic spine in a postmenopausal woman many years after hysterectomy and partial oophorectomy. There are currently no standard guidelines for treatment of BML, given the rare nature of this condition, with most patients treated with a combination of surgical resection and radiotherapy, followed by hormonal treatment and radiological surveillance serving as the primary backbone of current management plans. Given that these patients present a unique clinical challenge in terms of diagnosis and management, it is important to delineate and further examine these rare entities.

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