scholarly journals Accidental Trihexyphenidyl Intoxication in a Seven-Year-Old Child: A Case Report from Senegal

2021 ◽  
Vol 6 (3) ◽  
Author(s):  
Diagne I ◽  
◽  
Petit V ◽  
Boiro D ◽  
◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Case Report ◽  
Side Effects ◽  
Supportive Care ◽  
Gastric Lavage ◽  
High Dose ◽  
Extrapyramidal Side Effects ◽  
Accidental Ingestion ◽  
Anticholinergic Syndrome ◽  
Cholinergic Drug

Trihexyphenidyl or Artane® /Parkinane® is an anti-cholinergic drug belonging to the antimuscarinic class. It is used in the treatment of Parkinson’s disease and widely in psychiatry for the management of extrapyramidal side effects of neuroleptics. Its overdose leads to a central and peripheral anticholinergic syndrome. We report here the case of a seven-year-old Senegalese boy who developed signs of intoxication due to accidental ingestion of a high dose of trihexyphenidyl and recovered completely after administration of parenteral antipyretic, gastric lavage and supportive care in a paediatric setting.

scholarly journals The combination of levomepromazine (methotrimeprazine) and rotigotine enables the safe and effective management of refractory nausea and vomiting in a patient with idiopathic Parkinson’s disease

2018 ◽  
Vol 33 (1) ◽  
pp. 109-113 ◽  
Author(s):  
Jonathan Hindmarsh ◽  
Sharlene Hindmarsh ◽  
Mark Lee ◽  
Richard Telford
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Report ◽  
Side Effects ◽  
Locally Advanced ◽  
Nausea And Vomiting ◽  
Serous Carcinoma ◽  
Extrapyramidal Side Effects ◽  
Idiopathic Parkinson’S Disease ◽  
Idiopathic Parkinson's Disease

Background: This case report describes a patient with known idiopathic Parkinson’s disease, being managed with transdermal rotigotine, whose refractory nausea and vomiting was successfully controlled with subcutaneous levomepromazine. No drug-induced extrapyramidal side effects emerged. Case presentation: A patient was found to have a locally advanced serous carcinoma, causing secondary bowel obstruction. Furthermore, due to compromised oral access, the patient’s oral antiparkinsonian medications for motor control were converted to transdermal rotigotine. Unfortunately, the patient’s nausea and vomiting was refractory to a number of recommended antiemetic options. Case management: Low dose levomepromazine was administered on a, ‘when required’ basis, via subcutaneous injection. Case outcome: After the first dose of levomepromazine, the patient’s nausea and vomiting completely subsided and no extrapyramidal side effects were observed. This was confirmed by daily assessments, revealing no worsening of the motor symptoms associated with idiopathic Parkinson’s disease. Conclusions: The pharmacology of rotigotine and levomepromazine appear complementary and may allow for the simultaneous use of both drugs, with favourable outcomes. This case report highlights that rotigotine may afford protection against antipsychotic induced extrapyramidal side effects, while preserving antiemetic effects. Such combinations may have a role in the end-of-life management of idiopathic Parkinson’s disease.

Imipramine Poisoning

1980 ◽  
Vol 1 (10) ◽  
pp. 317-320
Author(s):  
Quang X. Nghiem ◽  
Randy C. Randel ◽  
Thomas L. Leach
Keyword(s):  
Case Report ◽  
Cardiogenic Shock ◽  
Cardiac Toxicity ◽  
Gastric Lavage ◽  
Anticholinergic Syndrome ◽  
Case Presentation ◽  
Common Cause ◽  
Adults And Children ◽  
Electrocardiographic Changes ◽  
Good Agent

The incidence of imipramine poisoning in adults and children is increasing. Toxic effects include an anticholinergic syndrome in the early phase and direct cardiotoxicity that produces abnormalities in rhythm, conduction, and depression of contractility in later phases. In fatal cases, the cardiotoxicity is the most common cause of death. Electrocardiographic changes are so characteristic of imipramine poisoning that the diagnosis can be made or at least suspected on the basis of electrocardiographic alteration. This is illustrated by the case report. Treatment includes induced emesis and/or gastric lavage to remove unabsorbed drug. Diazepam followed by phenobarbital is used to control seizures. Physostigmine is a good agent for treatment of the anticholinergic syndrome, including supraventricular hyperexcitability. Lidocaine is useful for ventricular hyperexcitability. As shown in the case presentation, epinephrine can be effective in reversing the most advanced manifestation of cardiac toxicity, cardiogenic shock.

OLANZAPINE INDUCED AMENORRHEA REVERSED BY SWITCHING TO ARIPIPRAZOLE- A RARE CASE REPORT

2021 ◽  
pp. 50-51
Author(s):  
Ankit Halder ◽  
Navna Panchami ◽  
Abhishek Das
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Rare Case ◽  
Atypical Antipsychotics ◽  
Extrapyramidal Side Effects ◽  
Rare Case Report

Due to less extrapyramidal side-effects ,atypical antipsychotics use in psychiatry has increased a lot. But it is associated with other metabolic and endocrine side effects. Olanzapine is one such antipsychotic that less likely to cause hyperprolactinemia which can present as amenorrhea in patients.Here we present a rare case of olanzapine induced amenorrhoea reversed by switching to Aripiprazole.

scholarly journals Extrapyramidal side effects and suicidal ideation under fluoxetine treatment: a case report

2010 ◽  
Vol 9 (1) ◽  
Author(s):  
Christos Christodoulou ◽  
Athanasia Papadopoulou ◽  
Emmanouil Rizos ◽  
Kalliopi Tournikioti ◽  
Xenia Gonda ◽  
...  
Keyword(s):  
Case Report ◽  
Suicidal Ideation ◽  
Side Effects ◽  
Extrapyramidal Side Effects ◽  
Fluoxetine Treatment

Risperidone-Induced Neuroleptic Malignant Syndrome: A Case Report and Review

1996 ◽  
Vol 41 (1) ◽  
pp. 52-54 ◽  
Author(s):  
Gb Meterissian
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Neuroleptic Malignant Syndrome ◽  
Clinical Features ◽  
Prior History ◽  
Extrapyramidal Side Effects ◽  
Life Threatening ◽  
History Of ◽  
Life Threatening Complication ◽  
The One

Objectives: 1. To report the case of a 53-year-old patient who developed neuroleptic malignant syndrome (NMS) — a rare but potentially life-threatening complication of neuroleptic therapy — 4 days after treatment with risperidone was initiated. 2. To review previously reported cases of NMS associated with risperidone. Methods: A computerized search of several databases, including MEDLINE, was conducted to find all previously reported cases of NMS with risperidone. Results: Five reported cases of risperidone-induced NMS were found in the literature. All cases including the one reported here displayed typical clinical features of NMS and all 6 patients had a prior history of extrapyramidal side effects and/or NMS. Age and duration of exposure to risperidone did not seem to be of significance. Conclusions: These cases illustrate that clinicians should be on the lookout for risperidone-induced NMS.

Defining Parkinsonism in the Canadian Study of Health and Aging

2001 ◽  
Vol 13 (S1) ◽  
pp. 107-113 ◽  
Author(s):  
Susan L. Mitchell ◽  
Kenneth Rockwood
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Side Effects ◽  
Operational Definition ◽  
Extrapyramidal Side Effects ◽  
Canadian Study ◽  
Resting Tremor ◽  
History Of ◽  
Gait Abnormalities ◽  
Definition Of

This study sought an operational definition of parkinsonism in elderly people (n = 2,914) who underwent a clinical examination in the Canadian Study of Health and Aging (CSHA). Parkinsonism was defined as having two of the following features: (1) bradykinesia of face or limbs, (2) resting tremor, (3) rigidity, and (4) abnormality of gait and posture. The association of parkinsonism with other parkinsonian-related features (prior diagnosis of Parkinson's disease, use of drugs with extrapyramidal side effects, and use of antiparkinsonian medications) and variables not expected to be related to parkinsonism (stroke and Hachinski score > 5) was determined. Parkinsonism was identified in 337 people (11.6%). It was significantly more likely with other parkinsonian-related characteristics, and was not associated with a history of stroke, but was slightly higher among those subjects with a Hachinski score > 5. Posture and gait abnormalities were significantly associated with other parkinsonian-related variables, but were also more common among subjects with stroke-related features. When the gait and posture disturbance category was excluded as a parkinsonian sign, the narrower definition was more specific but less sensitive in detecting cases with a clinical diagnosis of Parkinson's disease. Despite limitations, the approach presented in this article is a valid method to operationalize parkinsonism from the dataset.

Deterioration of parkinsonian symptoms following treatment of dopaminergic hallucinosis with olanzapine

1999 ◽  
Vol 14 (6) ◽  
pp. 356-357 ◽  
Author(s):  
J. Rudolf ◽  
M. Ghaemi ◽  
S. Schmülling
Keyword(s):  
Parkinson’S Disease ◽  
Side Effects ◽  
Atypical Antipsychotic ◽  
Antipsychotic Drug ◽  
Extrapyramidal Side Effects ◽  
Atypical Antipsychotic Drug ◽  
Extrapyramidal Syndrome ◽  
Olanzapine Treatment ◽  
Dopaminergic Psychosis ◽  
Paranoid Symptoms

SummaryThe atypical antipsychotic drug olanzapine has been proposed for treatment of dopaminergic psychosis in Parkinson's disease (PD). We report on a 68-year-old patient who developed a severe akinetic-rigid extrapyramidal syndrome, accompanied by additional paranoid symptoms, following olanzapine treatment of optic hallucinosis in PD. Olanzapine may also induce clinically relevant extrapyramidal side effects in PD patients.

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