Radical Functionalization of Thioglycosides in Aqueous Medium
Keyword(s):
<p>A visible-light-mediated thiol-ene reaction is successfully operated in aqueous medium. Organic photoredox catalyst (9-mesityl-10-methylacridinum tetrafluoroborate) is used to initiate the radical process to generate thiyl radicals upon light irradiation. Two reaction pathways are discovered in different aqueous buffer system. Thiol-ene adduct is preferred in acidity reaction medium; while disulfide formation is found to be favored in basic reaction medium. Moreover, a visible-light-mediated modified Danishefsky-Wan desulfurization is used to convert thioglycoside to highly substituted tetrahydropyran ring.</p>
1985 ◽
Vol 50
(8)
◽
pp. 1842-1851
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1999 ◽
Vol 64
(1)
◽
pp. 149-156
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2016 ◽
Vol 81
(16)
◽
pp. 7217-7229
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Keyword(s):
Keyword(s):