scholarly journals Reversible Photo-Control over Transmembrane Anion Transport Using Visible-Light Responsive Supramolecular Carriers

2020 ◽  
Author(s):  
Aidan Kerckhoffs ◽  
Matthew Langton
Keyword(s):  
Visible Light ◽  
Lipid Bilayer ◽  
Bilayer Membrane ◽  
Anion Transport ◽  
Temporal Control ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes ◽  
Spatio Temporal ◽  
Visible Wavelengths ◽  
External Signals

<p>Ion transport across lipid bilayer membranes in biology is controlled by membrane proteins, which in turn are regulated in response to chemical-, physical- and photo-stimuli. The design of synthetic supramolecular ion transporters able to be precisely controlled by external signals, in particular bio-compatible wavelengths of visible light, is key for achieving spatio-temporal control over function. Here we report two-colour responsive molecular photo-switches that act as supramolecular transmembrane anion carriers. Reversible switching of the photo-switch within the lipid bilayer membrane is achieved using biocompatible visible wavelengths of light, such that temporal control over transmembrane anion transport is achieved through alternating irradiation with red and blue light. </p>

scholarly journals Reversible Photo-Control over Transmembrane Anion Transport Using Visible-Light Responsive Supramolecular Carriers

2020 ◽  
Author(s):  
Aidan Kerckhoffs ◽  
Matthew Langton
Keyword(s):  
Visible Light ◽  
Lipid Bilayer ◽  
Bilayer Membrane ◽  
Anion Transport ◽  
Temporal Control ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes ◽  
Spatio Temporal ◽  
Visible Wavelengths ◽  
External Signals

<p>Ion transport across lipid bilayer membranes in biology is controlled by membrane proteins, which in turn are regulated in response to chemical-, physical- and photo-stimuli. The design of synthetic supramolecular ion transporters able to be precisely controlled by external signals, in particular bio-compatible wavelengths of visible light, is key for achieving spatio-temporal control over function. Here we report two-colour responsive molecular photo-switches that act as supramolecular transmembrane anion carriers. Reversible switching of the photo-switch within the lipid bilayer membrane is achieved using biocompatible visible wavelengths of light, such that temporal control over transmembrane anion transport is achieved through alternating irradiation with red and blue light. </p>

scholarly journals Coumarin-bisureas as potent fluorescent transmembrane anion transporters

2021 ◽  
Author(s):  
Mohamed Fares ◽  
Xin Wu ◽  
Daniel A. McNaughton ◽  
Alexander M. Gilchrist ◽  
William Lewis ◽  
...  
Keyword(s):  
Transport Properties ◽  
Lipid Bilayer ◽  
Anion Transport ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes ◽  
Anion Transporters

A series of fluorescent coumarin bis-ureas have been synthesised and their anion transport properties studied. The compounds function as highly potent HCl co-transport agents in lipid bilayer membranes.

scholarly journals Transmembrane anion transport mediated by halogen bonding and hydrogen bonding triazole anionophores

2020 ◽  
Vol 11 (18) ◽  
pp. 4722-4729 ◽  
Author(s):  
Laura E. Bickerton ◽  
Alistair J. Sterling ◽  
Paul D. Beer ◽  
Fernanda Duarte ◽  
Matthew J. Langton
Keyword(s):  
Hydrogen Bonding ◽  
Lipid Bilayer ◽  
Halogen Bonding ◽  
Anion Transport ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes ◽  
Triazole Derivatives ◽  
Anion Selectivity

Halogen and hydrogen bonding 1,2,3-triazole derivatives efficiently mediate anion transport across lipid bilayer membranes with unusual anion selectivity profiles.

scholarly journals Pores formed in lipid bilayer membranes by nystatin, Differences in its one-sided and two-sided action.

1975 ◽  
Vol 65 (4) ◽  
pp. 515-526 ◽  
Author(s):  
A Marty ◽  
A Finkelstein
Keyword(s):  
Hydrogen Bonding ◽  
Lipid Bilayer ◽  
Pore Formation ◽  
Plasma Membranes ◽  
Bilayer Membrane ◽  
Bilayer Structure ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes ◽  
The One

Nystatin and amphotericin B induce a cation-selective conductance when added to one side of a lipid bilayer membrane and an anion-selective conductance when added to both sides. The concentrations of antibiotic required for the one-sided action are comparable to those employed on plasma membranes and are considerably larger than those required for the two-sided action. We propose that the two-sided effect results from the formation of aqueous pores formed by the hydrogen bonding in the middle of the bilayer of two "half pores," whereas the one-sided effect results from the half pores alone. We discuss, in terms of the flexibility of bilayer structure and its thickness, how it is possible to have conducting half pores and "complete pores" in the same membrane. The role of sterol (cholesterol and ergosterol) in pore formation is also examined.

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