scholarly journals Pores formed in lipid bilayer membranes by nystatin, Differences in its one-sided and two-sided action.

1975 ◽  
Vol 65 (4) ◽  
pp. 515-526 ◽  
Author(s):  
A Marty ◽  
A Finkelstein
Keyword(s):  
Hydrogen Bonding ◽  
Lipid Bilayer ◽  
Pore Formation ◽  
Plasma Membranes ◽  
Bilayer Membrane ◽  
Bilayer Structure ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes ◽  
The One

Nystatin and amphotericin B induce a cation-selective conductance when added to one side of a lipid bilayer membrane and an anion-selective conductance when added to both sides. The concentrations of antibiotic required for the one-sided action are comparable to those employed on plasma membranes and are considerably larger than those required for the two-sided action. We propose that the two-sided effect results from the formation of aqueous pores formed by the hydrogen bonding in the middle of the bilayer of two "half pores," whereas the one-sided effect results from the half pores alone. We discuss, in terms of the flexibility of bilayer structure and its thickness, how it is possible to have conducting half pores and "complete pores" in the same membrane. The role of sterol (cholesterol and ergosterol) in pore formation is also examined.

Formation and stabilization of pores in bilayer membranes by peptide-like amphiphilic polymers

Soft Matter ◽  
2018 ◽  
Vol 14 (13) ◽  
pp. 2526-2534 ◽  
Author(s):  
Ankush Checkervarty ◽  
Marco Werner ◽  
Jens-Uwe Sommer
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Lipid Bilayer ◽  
Pore Formation ◽  
Amphiphilic Polymers ◽  
Amphiphilic Copolymers ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes ◽  
Fluid Membrane ◽  
Brush Model

We study pore formation in models of lipid bilayer membranes interacting with amphiphilic copolymers mimicking anti-microbial peptides using Monte Carlo simulations and we rationalize our results by a simple brush-model for the fluid membrane.

scholarly journals Reversible Photo-Control over Transmembrane Anion Transport Using Visible-Light Responsive Supramolecular Carriers

2020 ◽  
Author(s):  
Aidan Kerckhoffs ◽  
Matthew Langton
Keyword(s):  
Visible Light ◽  
Lipid Bilayer ◽  
Bilayer Membrane ◽  
Anion Transport ◽  
Temporal Control ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes ◽  
Spatio Temporal ◽  
Visible Wavelengths ◽  
External Signals

<p>Ion transport across lipid bilayer membranes in biology is controlled by membrane proteins, which in turn are regulated in response to chemical-, physical- and photo-stimuli. The design of synthetic supramolecular ion transporters able to be precisely controlled by external signals, in particular bio-compatible wavelengths of visible light, is key for achieving spatio-temporal control over function. Here we report two-colour responsive molecular photo-switches that act as supramolecular transmembrane anion carriers. Reversible switching of the photo-switch within the lipid bilayer membrane is achieved using biocompatible visible wavelengths of light, such that temporal control over transmembrane anion transport is achieved through alternating irradiation with red and blue light. </p>

scholarly journals Water and nonelectrolyte permeability of lipid bilayer membranes.

1976 ◽  
Vol 68 (2) ◽  
pp. 127-135 ◽  
Author(s):  
A Finkelstein
Keyword(s):  
Lipid Bilayer ◽  
Plasma Membranes ◽  
Diffusion Mechanism ◽  
Diffusion Constant ◽  
Lipid Bilayer Membranes ◽  
Straight Chain ◽  
Bilayer Membranes ◽  
Chain Molecules ◽  
General Average ◽  
D Values

Both the permeability coefficients (Pd's) through lipid bilayer membranes of varying composition (lecithin [L], lecithin:cholesterol [LC], and spingomyelin:cholesterol [SC]) and the n-hexadecane:water partition coefficients (Knc's) of H2O and seven nonelectrolytes (1,6 hexanediol, 1,4 butanediol, n-butyramide, isobutyramide, acetamide, formamide, and urea) were measured. For a given membrane compositiin, Pd/DKnc (where D is the diffusion constant in water) is the same for most of the molecules tested. There is no extraordinary dependence of Pd on molecular weight; thus, given Pd(acetamide), Pd(1,6 hexanediol) is correctly predicted from the Knc and D values for the two molecules. The major exceptions are H2O, whose value of Pd/DKnc is about 10-fold larger, and urea, whose value is about 5-fold smaller than the general average. In a "tight" membrane such as SC, Pd(n-butyramide)/Pd(isobutyramide)=2.5; thus this bilayer manifests the same sort of discrimination between branched and straight chain molecules as occurs in many plasma membranes. Although the absolute values of the Pd's change by more than a factor of 100 in going from the tightest membrane (SC) to the loosest (L), the relative values remain approximately constant. The general conclusion of this study is that H2O and nonelectrolytes cross lipid bilayer membranes by a solubility-diffusion mechanism, and that the bilayer interior is much more like an oil (a la Overton) than a rubber-like polymer (a la Lieb and Stein).

scholarly journals Transmembrane anion transport mediated by halogen bonding and hydrogen bonding triazole anionophores

2020 ◽  
Vol 11 (18) ◽  
pp. 4722-4729 ◽  
Author(s):  
Laura E. Bickerton ◽  
Alistair J. Sterling ◽  
Paul D. Beer ◽  
Fernanda Duarte ◽  
Matthew J. Langton
Keyword(s):  
Hydrogen Bonding ◽  
Lipid Bilayer ◽  
Halogen Bonding ◽  
Anion Transport ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes ◽  
Triazole Derivatives ◽  
Anion Selectivity

Halogen and hydrogen bonding 1,2,3-triazole derivatives efficiently mediate anion transport across lipid bilayer membranes with unusual anion selectivity profiles.

scholarly journals Pore formation by LamB of Escherichia coli in lipid bilayer membranes.

1986 ◽  
Vol 165 (3) ◽  
pp. 978-986 ◽  
Author(s):  
R Benz ◽  
A Schmid ◽  
T Nakae ◽  
G H Vos-Scheperkeuter
Keyword(s):  
Escherichia Coli ◽  
Lipid Bilayer ◽  
Pore Formation ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes
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