scholarly journals Nature to Nurture- Identifying Phytochemicals from Indian Medicinal Plants as Prophylactic Medicine by Rational Screening to Be Potent Against Multiple Drug Targets of SARS-CoV-2

2020 ◽  
Author(s):  
Pratap Kumar Parida ◽  
Dipak Paul ◽  
Debamitra Chakravorty
Keyword(s):  
Medicinal Plants ◽  
Drug Targets ◽  
Alternative Therapy ◽  
Health Sector ◽  
Multiple Drug ◽  
Natural Immunity ◽  
Protein Targets ◽  
Long Time ◽  
Potent Drug ◽  
Indian Medicinal Plants

The COVID-19 pandemic resulted in millions of people being quarantined, impacting the world economy and health sector. There is no existing proven treatment for this disease. It may takea long time until a good candidate vaccine or a potent drug is made available in the market. Therefore, there is a need to search for alternative therapy. In the context, this work explored natural compounds from Indian medicinal plants to develop a prophylactic treatment regimen that will be instrumentalin controlling the spread of the deadly virus. In this work 1916 phytochemicals from 55 Indian medicinal plants, reported to possess anti-viral properties, were subjected to virtual screening on 8 structural and non-structural SARS-CoV-2 protein targets. Docking interactions, ADME and toxicity profiles of the 66 screened phytochemicals were correlated with 21 repurposed drugs that have been most cited in literature to be effective against SARS-CoV-2. Steroidal lactones from Withaniasomnifera and triterpenoids from Azadirachtaindica- with docking score ranging from -13 kcal/mol upto -6 kcal/mol were identified to occupy the top scoring virtually screened phytochemicals against the various targets of SARS-CoV-2. Importantly this work proposes that a concoction of these phytochemicals can act as prophylactic anti-viral medicine to control the spread of SARS-CoV-2 and also enhance natural immunity as the first line of defence towards such a deadly virus.

scholarly journals Nature to Nurture- Identifying Phytochemicals from Indian Medicinal Plants as Prophylactic Medicine by Rational Screening to Be Potent Against Multiple Drug Targets of SARS-CoV-2

2020 ◽  
Author(s):  
Pratap Kumar Parida ◽  
Dipak Paul ◽  
Debamitra Chakravorty
Keyword(s):  
Medicinal Plants ◽  
Drug Targets ◽  
Alternative Therapy ◽  
Health Sector ◽  
Multiple Drug ◽  
Natural Immunity ◽  
Protein Targets ◽  
Long Time ◽  
Potent Drug ◽  
Indian Medicinal Plants

The COVID-19 pandemic resulted in millions of people being quarantined, impacting the world economy and health sector. There is no existing proven treatment for this disease. It may takea long time until a good candidate vaccine or a potent drug is made available in the market. Therefore, there is a need to search for alternative therapy. In the context, this work explored natural compounds from Indian medicinal plants to develop a prophylactic treatment regimen that will be instrumentalin controlling the spread of the deadly virus. In this work 1916 phytochemicals from 55 Indian medicinal plants, reported to possess anti-viral properties, were subjected to virtual screening on 8 structural and non-structural SARS-CoV-2 protein targets. Docking interactions, ADME and toxicity profiles of the 66 screened phytochemicals were correlated with 21 repurposed drugs that have been most cited in literature to be effective against SARS-CoV-2. Steroidal lactones from Withaniasomnifera and triterpenoids from Azadirachtaindica- with docking score ranging from -13 kcal/mol upto -6 kcal/mol were identified to occupy the top scoring virtually screened phytochemicals against the various targets of SARS-CoV-2. Importantly this work proposes that a concoction of these phytochemicals can act as prophylactic anti-viral medicine to control the spread of SARS-CoV-2 and also enhance natural immunity as the first line of defence towards such a deadly virus.

NURTURING HAIR

2021 ◽  
Author(s):  
Bhagyashali Karle
Keyword(s):  
Medicinal Plants ◽  
Present Review ◽  
Indian Women ◽  
Active Constituents ◽  
Ancient Time ◽  
Traditional Uses ◽  
Area Of Interest ◽  
Long Time ◽  
Hair Care ◽  
Indian Medicinal Plants

Hair is always remains intimate topic not only for women but also for men. Beautiful, healthy hair is intrinsic part of beauty and health. Even medicinal plants are always remains area of interest for the researchers. In these notion Indian medicinal plants, used for hair care has been given good results since ancient time. Hence Indian women are blessed with the healthy hair. In present review of the Indian medicinal plants, used for hair care since long time are listed. A book provides information for particular traditional uses of the plants for common hair problems as well as active constituents present in it. Original photographs of the plants also support to literature. This work may provide platform for further research in cosmeceutical studies.

scholarly journals Natures Therapy for COVID-19: Targeting the Vital Non-Structural Proteins (NSP) from SARS-CoV-2 with Phytochemicals from Indian Medicinal Plants

2020 ◽  
Author(s):  
Pratap Kumar Parida ◽  
Dipak Paul ◽  
Debamitra Chakravorty
Keyword(s):  
Medicinal Plants ◽  
Health Sector ◽  
Principal Component ◽  
Binding Energies ◽  
Structural Proteins ◽  
P Value ◽  
Pathway Enrichment Analysis ◽  
Binding Modes ◽  
Chemical Structures ◽  
Indian Medicinal Plants

Containing COVID-19 is still a global challenge. It has affected the "normal" world by<br>targeting its economy and health sector. Research is more focused on finding a cure to this<br>disease and is less concerned about other life threatening diseases like cancer. Thus we need to<br>develop a medical solution at the earliest. In this context the present work aimed to understand<br>the efficacy of 22 rationally screened phytochemicals from Indian medicinal plants obtained<br>from our previous work, following drug-likeness properties, against 6 non-structural-proteins<br>(NSP) from SARS-CoV-2. 100 ns molecular dynamics simulations were performed and<br>relative binding free energies were computed by MM/PBSA. Further, principal component<br>analysis, dynamic cross correlation and hydrogen bond occupancy were analyzed to<br>characterize protein–ligand interactions. Biological pathway enrichment analysis was also<br>carried out to elucidate the therapeutic targets of the phytochemicals in comparison to SARS-<br>CoV-2. The potential binding modes and favourable molecular interaction profile of 9<br>phytochemicals, majorly from Withania sominifera with lowest free binding energies, against<br>the SARS-CoV-2 NSP targets were identified. It was understood that phytochemicals and<br>repurposed drugs with steroidal moieties in their chemical structures formed stable interactions<br>with the NSPs. Additionally, human target pathway analysis for SARS-CoV-2 and<br>phytochemicals showed that cytokine mediated pathway and phosphorylation pathways were<br>with the most significant p-value. To summarize this work, we suggest a global approach of<br>targeting multiple proteins of SARS-CoV-2 with phytochemicals as a natural alternative<br>therapy for COVID-19. We also suggest that these phytochemicals need to be tested<br>experimentally to confirm their efficacy.

scholarly journals Natures Therapy for COVID-19: Targeting the Vital Non-Structural Proteins (NSP) from SARS-CoV-2 with Phytochemicals from Indian Medicinal Plants

2020 ◽  
Author(s):  
Pratap Kumar Parida ◽  
Dipak Paul ◽  
Debamitra Chakravorty
Keyword(s):  
Medicinal Plants ◽  
Health Sector ◽  
Principal Component ◽  
Binding Energies ◽  
Structural Proteins ◽  
P Value ◽  
Pathway Enrichment Analysis ◽  
Binding Modes ◽  
Chemical Structures ◽  
Indian Medicinal Plants

Containing COVID-19 is still a global challenge. It has affected the "normal" world by<br>targeting its economy and health sector. Research is more focused on finding a cure to this<br>disease and is less concerned about other life threatening diseases like cancer. Thus we need to<br>develop a medical solution at the earliest. In this context the present work aimed to understand<br>the efficacy of 22 rationally screened phytochemicals from Indian medicinal plants obtained<br>from our previous work, following drug-likeness properties, against 6 non-structural-proteins<br>(NSP) from SARS-CoV-2. 100 ns molecular dynamics simulations were performed and<br>relative binding free energies were computed by MM/PBSA. Further, principal component<br>analysis, dynamic cross correlation and hydrogen bond occupancy were analyzed to<br>characterize protein–ligand interactions. Biological pathway enrichment analysis was also<br>carried out to elucidate the therapeutic targets of the phytochemicals in comparison to SARS-<br>CoV-2. The potential binding modes and favourable molecular interaction profile of 9<br>phytochemicals, majorly from Withania sominifera with lowest free binding energies, against<br>the SARS-CoV-2 NSP targets were identified. It was understood that phytochemicals and<br>repurposed drugs with steroidal moieties in their chemical structures formed stable interactions<br>with the NSPs. Additionally, human target pathway analysis for SARS-CoV-2 and<br>phytochemicals showed that cytokine mediated pathway and phosphorylation pathways were<br>with the most significant p-value. To summarize this work, we suggest a global approach of<br>targeting multiple proteins of SARS-CoV-2 with phytochemicals as a natural alternative<br>therapy for COVID-19. We also suggest that these phytochemicals need to be tested<br>experimentally to confirm their efficacy.

scholarly journals Natures Therapy for COVID-19: Targeting the Vital Non-Structural Proteins (NSP) from SARS-CoV-2 with Phytochemicals from Indian Medicinal Plants

2020 ◽  
Author(s):  
Pratap Kumar Parida ◽  
Dipak Paul ◽  
Debamitra Chakravorty
Keyword(s):  
Medicinal Plants ◽  
Health Sector ◽  
Principal Component ◽  
Binding Energies ◽  
Structural Proteins ◽  
P Value ◽  
Pathway Enrichment Analysis ◽  
Binding Modes ◽  
Chemical Structures ◽  
Indian Medicinal Plants

Containing COVID-19 is still a global challenge. It has affected the "normal" world by<br>targeting its economy and health sector. Research is more focused on finding a cure to this<br>disease and is less concerned about other life threatening diseases like cancer. Thus we need to<br>develop a medical solution at the earliest. In this context the present work aimed to understand<br>the efficacy of 22 rationally screened phytochemicals from Indian medicinal plants obtained<br>from our previous work, following drug-likeness properties, against 6 non-structural-proteins<br>(NSP) from SARS-CoV-2. 100 ns molecular dynamics simulations were performed and<br>relative binding free energies were computed by MM/PBSA. Further, principal component<br>analysis, dynamic cross correlation and hydrogen bond occupancy were analyzed to<br>characterize protein–ligand interactions. Biological pathway enrichment analysis was also<br>carried out to elucidate the therapeutic targets of the phytochemicals in comparison to SARS-<br>CoV-2. The potential binding modes and favourable molecular interaction profile of 9<br>phytochemicals, majorly from Withania sominifera with lowest free binding energies, against<br>the SARS-CoV-2 NSP targets were identified. It was understood that phytochemicals and<br>repurposed drugs with steroidal moieties in their chemical structures formed stable interactions<br>with the NSPs. Additionally, human target pathway analysis for SARS-CoV-2 and<br>phytochemicals showed that cytokine mediated pathway and phosphorylation pathways were<br>with the most significant p-value. To summarize this work, we suggest a global approach of<br>targeting multiple proteins of SARS-CoV-2 with phytochemicals as a natural alternative<br>therapy for COVID-19. We also suggest that these phytochemicals need to be tested<br>experimentally to confirm their efficacy.

Current Status and Future Perspective for Research on Medicinal Plants with Anticancerous Activity and Minimum Cytotoxic Value

2019 ◽  
Vol 20 (12) ◽  
pp. 1227-1243
Author(s):  
Hina Qamar ◽  
Sumbul Rehman ◽  
D.K. Chauhan
Keyword(s):  
Side Effects ◽  
Medicinal Plants ◽  
Anticancer Agents ◽  
Drug Targets ◽  
Psidium Guajava ◽  
Current Status ◽  
Future Perspective ◽  
Wide Range

Cancer is the second leading cause of morbidity and mortality worldwide. Although chemotherapy and radiotherapy enhance the survival rate of cancerous patients but they have several acute toxic effects. Therefore, there is a need to search for new anticancer agents having better efficacy and lesser side effects. In this regard, herbal treatment is found to be a safe method for treating and preventing cancer. Here, an attempt has been made to screen some less explored medicinal plants like Ammania baccifera, Asclepias curassavica, Azadarichta indica, Butea monosperma, Croton tiglium, Hedera nepalensis, Jatropha curcas, Momordica charantia, Moringa oleifera, Psidium guajava, etc. having potent anticancer activity with minimum cytotoxic value (IC50 >3μM) and lesser or negligible toxicity. They are rich in active phytochemicals with a wide range of drug targets. In this study, these medicinal plants were evaluated for dose-dependent cytotoxicological studies via in vitro MTT assay and in vivo tumor models along with some more plants which are reported to have IC50 value in the range of 0.019-0.528 mg/ml. The findings indicate that these plants inhibit tumor growth by their antiproliferative, pro-apoptotic, anti-metastatic and anti-angiogenic molecular targets. They are widely used because of their easy availability, affordable price and having no or sometimes minimal side effects. This review provides a baseline for the discovery of anticancer drugs from medicinal plants having minimum cytotoxic value with minimal side effects and establishment of their analogues for the welfare of mankind.

Exploration of Ion Channels in Mycobacterium tuberculosis: Implication on Drug Discovery and Potent Drug Targets Against Tuberculosis

2020 ◽  
Vol 14 (1) ◽  
pp. 14-29
Author(s):  
Manish Dwivedi
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Drug Targets ◽  
Cell Envelope ◽  
Intracellular Pathogen ◽  
Host Immune System ◽  
Transporter Proteins ◽  
Channel Proteins ◽  
Medical Importance ◽  
Potent Drug ◽  
Emergence Of Resistance

Scientific interest in mycobacteria has been sparked by the medical importance of Mycobacterium tuberculosis (Mtb) that is known to cause severe diseases in mammals, i.e. tuberculosis and by properties that distinguish them from other microorganisms which are notoriously difficult to treat. The treatment of their infections is difficult because mycobacteria fortify themselves with a thick impermeable cell envelope. Channel and transporter proteins are among the crucial adaptations of Mycobacterium that facilitate their strength to combat against host immune system and anti-tuberculosis drugs. In previous studies, it was investigated that some of the channel proteins contribute to the overall antibiotic resistance in Mtb. Moreover, in some of the cases, membrane proteins were found responsible for virulence of these pathogens. Given the ability of M. tuberculosis to survive as an intracellular pathogen and its inclination to develop resistance to the prevailing anti-tuberculosis drugs, its treatment requires new approaches and optimization of anti-TB drugs and investigation of new targets are needed for their potential in clinical usage. Therefore, it is imperative to investigate the survival of Mtb. in stressed conditions with different behavior of particular channel/ transporter proteins. Comprehensive understanding of channel proteins and their mechanism will provide us direction to find out preventive measures against the emergence of resistance and reduce the duration of the treatment, eventually leading to plausible eradication of tuberculosis.

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