scholarly journals Expanding the Scope of Pyclen-Picolinate Lanthanide Chelates to Po-Tential Theranostic Applications

2020 ◽  
Author(s):  
Gwladys Nizou ◽  
Chiara Favaretto ◽  
Francesca Borgna ◽  
Pascal V. Grundler ◽  
Nathalie Saffon-Merceron ◽  
...  
Keyword(s):  
Solid State ◽  
Dft Calculations ◽  
Stability Constants ◽  
High Stability ◽  
Lanthanide Ions ◽  
Lanthanide Chelates ◽  
The Stability ◽  
Theranostic Applications ◽  
First Time ◽  
Very High

A family of three picolinate pyclen based ligands, previously investigated for the complexation of Y<sup>3+</sup> and some lanthanide ions (Gd<sup>3+</sup>, Eu<sup>3+</sup>), was studied with <sup>161</sup>Tb and <sup>177</sup>Lu in view of potential radiotherapeutic applications. The set of six Tb<sup>3+ </sup>and Lu<sup>3+ </sup>complexes was synthesized and fully characterized. The coordination properties in the solid state and in solution were thoroughly studied. Potentiometric titrations, corroborated by DFT calculations, showed the very high stability constants of the Tb<sup>3+</sup> and Lu<sup>3+</sup> complexes, which are associated to remarkable kinetic inertness. A complete radiolabeling study performed with both<sup> 161</sup>Tb and <sup>177</sup>Lu radionuclides, including experiments with regard to the stability with and without scavengers and kinetic inertness using challenging agents, proved that the ligands could reasonably compete with the DOTA analogue. To conclude, the potential of using the same ligand for both radiotherapy and optical imaging was highlighted for the first time.

scholarly journals Expanding the Scope of Pyclen-Picolinate Lanthanide Chelates to Po-Tential Theranostic Applications

2020 ◽  
Author(s):  
Gwladys Nizou ◽  
Chiara Favaretto ◽  
Francesca Borgna ◽  
Pascal V. Grundler ◽  
Nathalie Saffon-Merceron ◽  
...  
Keyword(s):  
Solid State ◽  
Dft Calculations ◽  
Stability Constants ◽  
High Stability ◽  
Lanthanide Ions ◽  
Lanthanide Chelates ◽  
The Stability ◽  
Theranostic Applications ◽  
First Time ◽  
Very High

A family of three picolinate pyclen based ligands, previously investigated for the complexation of Y<sup>3+</sup> and some lanthanide ions (Gd<sup>3+</sup>, Eu<sup>3+</sup>), was studied with <sup>161</sup>Tb and <sup>177</sup>Lu in view of potential radiotherapeutic applications. The set of six Tb<sup>3+ </sup>and Lu<sup>3+ </sup>complexes was synthesized and fully characterized. The coordination properties in the solid state and in solution were thoroughly studied. Potentiometric titrations, corroborated by DFT calculations, showed the very high stability constants of the Tb<sup>3+</sup> and Lu<sup>3+</sup> complexes, which are associated to remarkable kinetic inertness. A complete radiolabeling study performed with both<sup> 161</sup>Tb and <sup>177</sup>Lu radionuclides, including experiments with regard to the stability with and without scavengers and kinetic inertness using challenging agents, proved that the ligands could reasonably compete with the DOTA analogue. To conclude, the potential of using the same ligand for both radiotherapy and optical imaging was highlighted for the first time.

Persistence in the fine-scale distribution and spatial aggregation of fishing

2018 ◽  
Vol 76 (4) ◽  
pp. 1072-1082 ◽  
Author(s):  
Niels T Hintzen ◽  
Geert Aarts ◽  
Adriaan D Rijnsdorp
Keyword(s):  
High Stability ◽  
Large Scale ◽  
Spatial Scales ◽  
Negative Relationship ◽  
Fishing Effort ◽  
Local Scale ◽  
Fine Scale ◽  
Effort Allocation ◽  
The Stability ◽  
First Time

Abstract High-resolution vessel monitoring (VMS) data have led to detailed estimates of the distribution of fishing in both time and space. While several studies have documented large-scale changes in fishing distribution, fine-scale patterns are still poorly documented, despite VMS data allowing for such analyses. We apply a methodology that can explain and predict effort allocation at fine spatial scales; a scale relevant to assess impact on the benthic ecosystem. This study uses VMS data to quantify the stability of fishing grounds (i.e. aggregated fishing effort) at a microscale (tens of meters). The model links effort registered at a large scale (ICES rectangle; 1° longitude × 0.5° latitude, ˜3600 km2) to fine spatial trawling intensities at a local scale (i.e. scale matching gear width, here 24 m). For the first time in the literature, the method estimates the part of an ICES rectangle that is unfavourable or inaccessible for fisheries, which is shown to be highly stable over time and suggests higher proportions of inaccessible grounds for either extremely muddy or courser substrates. The study furthermore shows high stability in aggregation of fishing, where aggregation shows a positive relationship with depth heterogeneity and a negative relationship with year-on-year variability in fishing intensity.

Complexation of Actinides with Amide Derivatives of Oxydiacetic Acid

2005 ◽  
Vol 893 ◽  
Author(s):  
Linfeng Rao ◽  
Guoxin Tian
Keyword(s):  
Stability Constants ◽  
Structural Information ◽  
Lanthanide Ions ◽  
Carboxylate Groups ◽  
Amide Derivatives ◽  
Ether Oxygen ◽  
The Difference ◽  
Solid Compounds ◽  
The Stability ◽  
Oxydiacetic Acid

AbstractComplexation of Np(V), U(VI) and Nd(III) with dimethyl-3-oxa-glutaramic acid (DMOGA) and tetramethyl-3-oxa-glutaramide (TMOGA) was studied in comparison with the complexation with oxydiacetic acid (ODA). Stability constants and enthalpy of complexation were determined by potentiometry, spectrophotometry and calorimetry. Thermodynamic parameters, in conjunction with structural information of solid compounds, indicate that DMOGA and TMOGA form tridentate complexes with the ether-oxygen participating in bonding with actinide/lanthanide ions. The trends in the stability constants, enthalpy and entropy of complexation are discussed in terms of the difference in the hydration of the amide groups and carboxylate groups and the difference in the charge density of the metal ions.

Structural and thermodynamic investigation of AnIVLI(O)HOPO

2017 ◽  
Vol 41 (19) ◽  
pp. 11291-11298 ◽  
Author(s):  
J. Aupiais ◽  
A. Younes ◽  
P. Moisy ◽  
C. Hennig ◽  
A. Rossberg ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Capillary Electrophoresis ◽  
Stability Constants ◽  
Inductively Coupled Plasma ◽  
Chelating Agents ◽  
Thermodynamic Investigation ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
The Stability ◽  
First Time

For the first time, capillary electrophoresis coupled with inductively coupled plasma mass spectrometry has been used to determine the stability constants of PuIV with the multidentate hydroxypyridinonate chelating agents LI(O)HOPO in 0.1 M NaNO3 solution, pcH = 1.395 at 25 °C through competition with the NTA ligand.

Crystal Structure of Pyridoxal Amino Methyl Phosphonic Acid (PYRAMPA) and Its Stability Constants with Al3+

2013 ◽  
Vol 1 ◽  
pp. 194308921350703
Author(s):  
Yahia Z. Hamada ◽  
Wesley R. Harris ◽  
Nigam P. Rath
Keyword(s):  
Crystal Structure ◽  
Aqueous Solutions ◽  
Stability Constants ◽  
Phosphonic Acid ◽  
High Stability ◽  
Deionized Water ◽  
Multidentate Ligand ◽  
Green Materials ◽  
Living Organisms ◽  
Very High

The crystal structure of the newly synthesized ligand pyridoxal amino methyl phosphonic acid (PYRAMPA) from green materials in deionized water and methanol is presented. It took only two steps to prepare this new ligand. The ligands’ stability constants with Al3+ are also reported in aqueous solutions at 25 °C ± 0.1 °C. The ligand was introduced as part of our concerted efforts to identify and synthesize an orally effective aluminum sequestering agent due to the known toxic effect of aluminum in living organisms particularly humans. PYRAMPA is a multidentate ligand suitable to sequester aluminum with very high stability.

Effect of species composition on stability and reproductivity of a small-scale microcosm system

1994 ◽  
Vol 30 (10) ◽  
pp. 125-131 ◽  
Author(s):  
N. Tanaka ◽  
Y. Inamori ◽  
K. Murakami ◽  
T. Akamatsu ◽  
Y. Kurihara
Keyword(s):  
Species Composition ◽  
High Stability ◽  
Genetically Engineered ◽  
Small Scale ◽  
Genetically Engineered Microorganisms ◽  
Ecosystem Level ◽  
The Stability ◽  
Very High

In this study, the effect of species composition on the stability and reproductivity of small-scale microcosm system was investigated. Small-scale microcosm system in this study was gnotobiotic type, which consisted of micro animals as predator, algae as producer and bacteria as decomposer. Three species of protozoa and three species of metazoa as predator, seven species of algae as producer and four species of bacteria as decomposer were employed. With these microorganisms, twenty-four sorts of species composition were made to investigate their effect on stability and reproductivity of microcosm system. As a result, some systems showed very high stability and reproductivity while some did not. And it was suggested that this high stable and reproductive microcosm system can be used as one of tools to assess the effect of genetically engineered microorganisms, micro pollutant and so forth on ecosystem level, because has enough capability to be applied as standard.

Surface Hydroxyl OH Defects of η-Al2O3 and χ-Al2O3 by Solid State NMR, XRD, and DFT Calculations

2017 ◽  
Vol 231 (4) ◽  
Author(s):  
Dzhalil F. Khabibulin ◽  
Evgeniy Papulovskiy ◽  
Andrey S. Andreev ◽  
Aleksandr A. Shubin ◽  
Alexander M. Volodin ◽  
...  
Keyword(s):  
Solid State ◽  
Dft Calculations ◽  
Solid State Nmr ◽  
Detailed Structure ◽  
Surface Hydroxyl ◽  
Oh Defects ◽  
First Time

AbstractFor the first time, the detailed structure of χ-Al

scholarly journals Tales of the Unexpected: The Case of Zirconium(IV) Complexes with Desferrioxamine

Molecules ◽  
2019 ◽  
Vol 24 (11) ◽  
pp. 2098 ◽  
Author(s):  
Matteo Savastano ◽  
Carla Bazzicalupi ◽  
Giovanni Ferraro ◽  
Emiliano Fratini ◽  
Paola Gratteri ◽  
...  
Keyword(s):  
Stability Constants ◽  
Density Functional ◽  
Maldi Mass Spectrometry ◽  
Binuclear Complexes ◽  
X Ray Scattering ◽  
Complex Solutions ◽  
The Stability ◽  
Ph Range ◽  
First Time

The Zr4+ complexes with desferrioxamine (H3DFO) and its derivatives are the only 89Zr-based imaging agents for proton emission tomography (PET) that have been used so far in clinical trials. Nevertheless, a complete speciation of the Zr4+/H3DFO system in solution has never been performed and the stability constants of the relevant complexes are still unknown. Here we report, for the first time, the speciation of this system in water, performed by potentiometric titrations, and the determination of the stability constants of all complexes formed in the pH range 2.5–11.5. Surprisingly, although desferrioxamine gives rise to very stable 1:1 complexes with Zr4+ (logK = 36.14 for Zr4+ + DFO3− = [ZrDFO]+), 2:2 and 2:3 ones are also formed in solution. Depending on the conditions, these binuclear complexes can be main species in solution. These results were corroborated by small-angle X-ray scattering (SAXS) and MALDI mass spectrometry analyses of complex solutions. Information on complex structures was obtained by means of density functional theory (DFT) calculations.

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