A Photocatalytic Regioselective Hydroaminoalkylation of Aryl-Substituted Alkenes with Simple Amines
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Scale Up
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A photocatalytic method for the alpha-selective hydroaminoalkylation of cinnamate esters has been developed. The reaction involves the regioselective addition of alpha-aminoalkyl radicals generated from aniline derivatives or aliphatic amines to the alpha-position of unsaturated esters. The scope of aromatic alkenes was extended to styrenes undergoing hydroaminoalkylation with anti-Markovnikov selectivity, which confirms the importance of the aromatic group at the beta-position. Simple scale-up is demonstrated under continuous-flow conditions, highlighting the practicality of the method.<br>
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2004 ◽
Vol 232
(2-3)
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pp. 175-181
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2008 ◽
Vol 18
(6)
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pp. 922-927
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