scholarly journals Distribution of Oral Submucous Fibrosis Cases and Malignant Transformation Rate among Bhutanese Patients Treated at Jigme Dorji Wangchuck National Referral Hospital, Bhutan

2021 ◽  
Vol 4 (12) ◽  
pp. OR7-OR10
Author(s):  
Pratap Singh Tamang ◽  
Gyan Prasad Bajgai ◽  
Hari Prasad Pokhrel
Keyword(s):  
Retrospective Study ◽  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Referral Hospital ◽  
Transformation Rate ◽  
Limited Mouth Opening ◽  
High Burden ◽  
Submucous Fibrosis ◽  
National Referral Hospital

BACKGROUND: Oral Submucous Fibrosis (OSMF) is a chronic, insidious, scarring disease of the mouth often involving the palate, oro-pharynx, pharynx, esophagus, tongue and the buccal mucosa which leads to ulceration, blanching and ultimately limited mouth opening. The aim of the study is to describe the age, gender and district-wise distribution of oral submucous fibrosis cases and to assess the malignant transformation rate among the patients with oral submucous fibrosis who were treated at Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan.MATERIALS AND METHOD: This is a descriptive retrospective study. The patients were clinically diagnosed by examining their mouth and by measuring their mouth opening (Inter-incisal height). Patients who had less than 3 fingers mouth opening and diagnosed as Oral submucous fibrosis (OSMF) during these three-year period from 2018 to 2020 were considered for the study.RESULTS: There were 278 cases in total. Thimphu district had the maximum number of cases followed by Wangduephodrang and Samtse. Gasa and Haa districts had the minimum cases. More males were affected than females. The malignant transformation rate among these patients was 4.3%.CONCLUSION: Thimphu district had the highest proportion of OSMF cases and was almost equally distributed among genders. Over 90% of the patients reported improvement without surgery while the malignancy transformation rate was 4.3%. The study recommends conducting screening in districts with high burden of OSMF cases for early diagnosis and treatment.

scholarly journals Vascular endothelial growth factor (VEGF) gene polymorphism in oral submucous fibrosis subjects - A preliminary study

2016 ◽  
Vol 7 (5) ◽  
pp. 10-16 ◽  
Author(s):  
Devishree V Rai ◽  
Kruthika S Guttal ◽  
Bhusan B Kulkarni ◽  
Shivaprakash Hiremath ◽  
Krishna N Burde
Keyword(s):  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Control Group ◽  
Transformation Rate ◽  
Significant Finding ◽  
Vegf Gene ◽  
Oral Potentially Malignant Disorders ◽  
Male Predominance ◽  
Submucous Fibrosis

Background: Oral Submucous Fibrosis is one of the oral potentially malignant disorders presenting with progressive restriction in mouth opening. The condition having a high malignant transformation rate necessitates identification of biomarkers to be employed for early detection of malignant change. This will influence the prognosis in addition to adding better quality of life to patients.Aims and Objectives: To relate the association of VEGF -460C/T polymorphism in patients with OSMF and to compare the same among healthy subjects.Materials and Methods: Thirty patients with Oral submucous fibrosis and 20 controls free from habits and any form of lesions were included in the study. The polymorphism of VEGF gene was detected by polymerase chain reaction-based restriction analysis.Results: Sixty-four percent of the population in the study was in the age group of 21-40 yrs suggesting the prominence of disease in younger individuals with male predominance. With reference to polymorphism, 6.67% of the subjects from OSMF group showed CT polymorphism and 16.67% showed TT polymorphism. There were no statistically significant differences in the polymorphism between the study group and controls. However the frequency of T allele in the patient group 12 (20%) was greater than that in the control group 1 (2.5%), which was a significant finding. There was no association between the habits, frequency of habits, duration of quid placement, site of quid placement and style of chewing with the nature of polymorphism. Conclusion: VEGF 460C/T has the potential to be used as a prognostic marker in predicting the malignant transformation of OSMF.Asian Journal of Medical Sciences Vol.7(5) 2016 10-16

Carcinogenesis of Male Oral Submucous Fibrosis Alters Salivary Microbiomes

2020 ◽  
pp. 002203452096875
Author(s):  
M.Y. Chen ◽  
J.W. Chen ◽  
L.W. Wu ◽  
K.C. Huang ◽  
J.Y. Chen ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Oral Microbiome ◽  
Premalignant Lesions ◽  
Rrna Gene ◽  
Transformation Rate ◽  
Validation Data ◽  
Oral Carcinogenesis ◽  
Key Species ◽  
Submucous Fibrosis

Most oral squamous cell carcinoma (OSCC) tumors arise from oral premalignant lesions. Oral submucous fibrosis (OSF), usually occurring in male chewers of betel quid, is a premalignant stromal disease characterized by a high malignant transformation rate and high prevalence. Although a relationship between the inhabited microbiome and carcinogenesis has been proposed, no detailed information regarding the oral microbiome of patients with OSF exists; the changes of the salivary microbiome during cancer formation remain unclear. This study compared the salivary microbiomes of male patients with OSCC and a predisposing OSF background (OSCC-OSF group) and those with OSF only (OSF group). The results of high-throughput sequencing of the bacterial 16S rRNA gene indicated that OSF-related carcinogenesis and smoking status significantly contributed to phylogenetic composition variations in the salivary microbiome, leading to considerable reductions in species richness and phylogenetic diversity. The microbiome profile of OSF-related malignancy was associated with increased microbial stochastic fluctuation, which dominated the salivary microbiome assembly and caused species co-occurrence network collapse. Artificial intelligence selection algorithms consistently identified 5 key species in the OSCC-OSF group: Porphyromonas catoniae, Prevotella multisaccharivorax, Prevotella sp. HMT-300, Mitsuokella sp. HMT-131, and Treponema sp. HMT-927. Robust accuracy in predicting oral carcinogenesis was obtained with our exploratory and validation data sets. In functional analysis, the microbiome of the OSCC-OSF group had greater potential for S-adenosyl-l-methionine and norspermidine synthesis but lower potential for l-ornithine and pyrimidine deoxyribonucleotide synthesis and formaldehyde metabolism. These findings indicated that the salivary microbiome plays important roles in modulating microbial metabolites during oral carcinogenesis. In conclusion, our results provided new insights into salivary microbiome alterations during the malignant transformation of OSF.

scholarly journals PROSTHODONTIC REHABILITATION OF A PATIENT WITH ORAL SUBMUCOUS FIBROSIS AND MICROSTOMIA : A CASE REPORT

2012 ◽  
Vol 02 (02) ◽  
pp. 68-71
Author(s):  
Anupama Prasad D. ◽  
Krishna Prasad D. ◽  
Chethan Hegde
Keyword(s):  
Case Report ◽  
Female Patient ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Complete Denture ◽  
Limited Mouth Opening ◽  
Submucous Fibrosis

AbstractThis case report deals with treatment of a female patient aged 45 years with limited mouth opening due to submucous fibrosis ,who was completely edentulous and was prosthetically treated with modification of techniques for impression making and jaw relation so that a complete denture was made without sections which could be easily inserted and removed without compromising retention and esthetics.

scholarly journals Oral submucous fibrosis: Histopathological features with pathophysiologic correlations

2021 ◽  
Vol 6 (3) ◽  
pp. 211-215
Author(s):  
Sanpreet Singh Sachdev ◽  
Yogita Bhaginath Adhane ◽  
Manisha Ahire Sardar ◽  
Tabita Joy Chettiankandy ◽  
Sarang Gautam Sonawane
Keyword(s):  
Connective Tissue ◽  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Survival Rates ◽  
Clinical Manifestations ◽  
Response To Treatment ◽  
Transformation Rate ◽  
Histopathological Features ◽  
Potentially Malignant ◽  
Submucous Fibrosis

Oral submucous fibrosis (OSMF) is a potentially malignant disorder characterized by juxtaepithelial inflammation and progressive fibrosis of submucosal tissues. It may affect any part of the oral cavity, as well as pharynx and oesophagus. The pathogenesis of OSMF may be attributable to habitual chewing of areca nut and its products, which is more prevalent amongst young population of South East Asia and India. Various histopathological features in different tissue components- epithelial, connective tissue stroma, muscle and salivary gland may be observed along the course of this chronic disorder. In connective tissue, extensive fibrosis with progressive hyalinization of collagen fibers and muscles accompanied by inflammatory response is considered to be pathognomonic feature. Advanced stages of OSMF may show atrophic changes or even dysplasia in the epithelium which may undergo malignant transformation. Malignant transformation rate of OSMF has been proved to be around 7.5%. Thus, identification of early histopathological changes in OSMF can lead to improved survival rates. The present article illustrates the various histopathological features observed during different stages of development of OSMF. A better understanding of the correlation between histopathological features and corresponding clinical manifestations can aid dental surgeons in prognostication of the lesion and determining response to treatment.

Malignant transformation rate in oral submucous fibrosis over a 17-year period

1985 ◽  
Vol 13 (6) ◽  
pp. 340-341 ◽  
Author(s):  
P.R. Murti ◽  
R.B. Bhonsle ◽  
J. J. Pindborg ◽  
D.K. Daftary ◽  
P.C. Gupta ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Transformation Rate ◽  
Submucous Fibrosis

scholarly journals Rebamipide to Manage Stomatopyrosis in Oral Submucous Fibrosis

2016 ◽  
Vol 17 (12) ◽  
pp. 1009-1012 ◽  
Author(s):  
Joanna Baptist ◽  
Shrijana Shakya
Keyword(s):  
Repeated Measures ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Standard Of Care ◽  
Burning Sensation ◽  
Limited Mouth Opening ◽  
Repeated Measures Analysis ◽  
Intralesional Steroid ◽  
Submucous Fibrosis ◽  
Oral Burning

ABSTRACT Introduction Oral submucous fibrosis (OSF) causes progressive debilitating symptoms, such as oral burning sensation (stomatopyrosis) and limited mouth opening. The standard of care (SOC) protocol includes habit cessation, intralesional steroid and hyaluronidase injections, and mouth opening exercises. The objective of the study was to evaluate efficacy of rebamipide in alleviating burning sensation of the oral mucosa in OSF in comparison with SOC intralesional steroid injections. Materials and methods Twenty OSF patients were divided into two groups [rebamipide (100 mg TID for 21 days) and betamethasone (4 mg/mL biweekly for 4 weeks)] of 10 each by random sampling. Burning sensation was assessed every week for 1 month. Burning sensation scores were analyzed using repeated measures analysis of variance (ANOVA) and paired t-test. Results Change in burning sensation score was significant (p < 0.05) in the first four visits. However, score between the 4th and 5th visit was not statistically significant (p > 0.05). Conclusion Our study has shown that rebamipide can be considered as an effective modality to manage burning sensation in patients suffering from OSF. Clinical significance Considering stomatopyrosis and trismus as a major cause for inability to eat in OSF, use of newer adjunctive modalities, such as rebamipide will ease patients suffering and also encourage them to consume food. How to cite this article Baptist J, Shakya S, Ongole R. Rebamipide to Manage Stomatopyrosis in Oral Submucous Fibrosis. J Contemp Dent Pract 2016;17(12):1009-1012.

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