scholarly journals Vascular endothelial growth factor (VEGF) gene polymorphism in oral submucous fibrosis subjects - A preliminary study

2016 ◽  
Vol 7 (5) ◽  
pp. 10-16 ◽  
Author(s):  
Devishree V Rai ◽  
Kruthika S Guttal ◽  
Bhusan B Kulkarni ◽  
Shivaprakash Hiremath ◽  
Krishna N Burde
Keyword(s):  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Control Group ◽  
Transformation Rate ◽  
Significant Finding ◽  
Vegf Gene ◽  
Oral Potentially Malignant Disorders ◽  
Male Predominance ◽  
Submucous Fibrosis

Background: Oral Submucous Fibrosis is one of the oral potentially malignant disorders presenting with progressive restriction in mouth opening. The condition having a high malignant transformation rate necessitates identification of biomarkers to be employed for early detection of malignant change. This will influence the prognosis in addition to adding better quality of life to patients.Aims and Objectives: To relate the association of VEGF -460C/T polymorphism in patients with OSMF and to compare the same among healthy subjects.Materials and Methods: Thirty patients with Oral submucous fibrosis and 20 controls free from habits and any form of lesions were included in the study. The polymorphism of VEGF gene was detected by polymerase chain reaction-based restriction analysis.Results: Sixty-four percent of the population in the study was in the age group of 21-40 yrs suggesting the prominence of disease in younger individuals with male predominance. With reference to polymorphism, 6.67% of the subjects from OSMF group showed CT polymorphism and 16.67% showed TT polymorphism. There were no statistically significant differences in the polymorphism between the study group and controls. However the frequency of T allele in the patient group 12 (20%) was greater than that in the control group 1 (2.5%), which was a significant finding. There was no association between the habits, frequency of habits, duration of quid placement, site of quid placement and style of chewing with the nature of polymorphism. Conclusion: VEGF 460C/T has the potential to be used as a prognostic marker in predicting the malignant transformation of OSMF.Asian Journal of Medical Sciences Vol.7(5) 2016 10-16

scholarly journals Distribution of Oral Submucous Fibrosis Cases and Malignant Transformation Rate among Bhutanese Patients Treated at Jigme Dorji Wangchuck National Referral Hospital, Bhutan

2021 ◽  
Vol 4 (12) ◽  
pp. OR7-OR10
Author(s):  
Pratap Singh Tamang ◽  
Gyan Prasad Bajgai ◽  
Hari Prasad Pokhrel
Keyword(s):  
Retrospective Study ◽  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Referral Hospital ◽  
Transformation Rate ◽  
Limited Mouth Opening ◽  
High Burden ◽  
Submucous Fibrosis ◽  
National Referral Hospital

BACKGROUND: Oral Submucous Fibrosis (OSMF) is a chronic, insidious, scarring disease of the mouth often involving the palate, oro-pharynx, pharynx, esophagus, tongue and the buccal mucosa which leads to ulceration, blanching and ultimately limited mouth opening. The aim of the study is to describe the age, gender and district-wise distribution of oral submucous fibrosis cases and to assess the malignant transformation rate among the patients with oral submucous fibrosis who were treated at Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan.MATERIALS AND METHOD: This is a descriptive retrospective study. The patients were clinically diagnosed by examining their mouth and by measuring their mouth opening (Inter-incisal height). Patients who had less than 3 fingers mouth opening and diagnosed as Oral submucous fibrosis (OSMF) during these three-year period from 2018 to 2020 were considered for the study.RESULTS: There were 278 cases in total. Thimphu district had the maximum number of cases followed by Wangduephodrang and Samtse. Gasa and Haa districts had the minimum cases. More males were affected than females. The malignant transformation rate among these patients was 4.3%.CONCLUSION: Thimphu district had the highest proportion of OSMF cases and was almost equally distributed among genders. Over 90% of the patients reported improvement without surgery while the malignancy transformation rate was 4.3%. The study recommends conducting screening in districts with high burden of OSMF cases for early diagnosis and treatment.

Carcinogenesis of Male Oral Submucous Fibrosis Alters Salivary Microbiomes

2020 ◽  
pp. 002203452096875
Author(s):  
M.Y. Chen ◽  
J.W. Chen ◽  
L.W. Wu ◽  
K.C. Huang ◽  
J.Y. Chen ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Oral Microbiome ◽  
Premalignant Lesions ◽  
Rrna Gene ◽  
Transformation Rate ◽  
Validation Data ◽  
Oral Carcinogenesis ◽  
Key Species ◽  
Submucous Fibrosis

Most oral squamous cell carcinoma (OSCC) tumors arise from oral premalignant lesions. Oral submucous fibrosis (OSF), usually occurring in male chewers of betel quid, is a premalignant stromal disease characterized by a high malignant transformation rate and high prevalence. Although a relationship between the inhabited microbiome and carcinogenesis has been proposed, no detailed information regarding the oral microbiome of patients with OSF exists; the changes of the salivary microbiome during cancer formation remain unclear. This study compared the salivary microbiomes of male patients with OSCC and a predisposing OSF background (OSCC-OSF group) and those with OSF only (OSF group). The results of high-throughput sequencing of the bacterial 16S rRNA gene indicated that OSF-related carcinogenesis and smoking status significantly contributed to phylogenetic composition variations in the salivary microbiome, leading to considerable reductions in species richness and phylogenetic diversity. The microbiome profile of OSF-related malignancy was associated with increased microbial stochastic fluctuation, which dominated the salivary microbiome assembly and caused species co-occurrence network collapse. Artificial intelligence selection algorithms consistently identified 5 key species in the OSCC-OSF group: Porphyromonas catoniae, Prevotella multisaccharivorax, Prevotella sp. HMT-300, Mitsuokella sp. HMT-131, and Treponema sp. HMT-927. Robust accuracy in predicting oral carcinogenesis was obtained with our exploratory and validation data sets. In functional analysis, the microbiome of the OSCC-OSF group had greater potential for S-adenosyl-l-methionine and norspermidine synthesis but lower potential for l-ornithine and pyrimidine deoxyribonucleotide synthesis and formaldehyde metabolism. These findings indicated that the salivary microbiome plays important roles in modulating microbial metabolites during oral carcinogenesis. In conclusion, our results provided new insights into salivary microbiome alterations during the malignant transformation of OSF.

scholarly journals Effectiveness of Pentoxifylline in the treatment of oral submucous fibrosis patients: a case-control study

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Annette M. Bhambal ◽  
Ajay Bhambal ◽  
U. S. Shukla ◽  
Aashna Dhingra
Keyword(s):  
Case Control Study ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Case Control ◽  
Control Group ◽  
Study Group ◽  
Base Line ◽  
Submucous Fibrosis ◽  
U Value ◽  
Control Study

Abstract Background Oral submucous fibrosis (OSMF) is a potentially malignant disorder largely seen in the South-Asian countries where areca nut is found to be the main predisposing factor. Pentoxifylline, a methylxanthine derivative, has vasodilating properties and is believed to increase the vascularity of the mucosal layer. This study was designed to determine the effect of pentoxifylline (Trental) on the clinical progression of oral submucous fibrosis. Aim: The present study was aimed to evaluate the effectiveness of drug pentoxifylline in the management of OSMF and to correlate the clinical parameters evaluated before and after treatment. Methods Study Design: This investigation was conducted as a case-control study incorporating a Control Group in comparison to a Study Group where pentoxifylline 400 mg was administered 3 times daily, as coated, sustained-release tablets for prescribed for 3 months. The stipulated period for the study was 8 months and a total of 80 cases of oral submucous fibrosis (40 test subjects and 40 controls) were included in this study and 100% acquiescence was reported at the end of the test period. Results Mild dizziness and gastric irritation were the only untoward symptoms reported in 2 of the volunteers in the study group during this trial. These were managed by diet protocols. A review of the patients and controls was done at an interval of every 4 weeks for 3 months. The subjective and objective measurements were recorded. The follow-up data at each visit concerning each other and to base-line values were calibrated using nonparametric tests of the Chi-Square test and Mann-Whitney. Significant comparisons with regard to improvement were recorded as objective criteria of mouth opening (u value =1.137, p = 0.260), tongue protrusion (u value = 0.262, p = 0.794 and cheek flexibility (u value =0.990, p = 0.326). Subjective symptoms of burning sensation of mouth (U value = 2.673, p = 0.008), pain on opening the mouth (U value = 4.320, p < 0.0001), difficulty in swallowing and difficulty in the speech were also recorded. Conclusion This study showed the effectiveness of pentoxifylline as an additional therapy in the routine management of oral submucous fibrosis.

scholarly journals Oral submucous fibrosis: Histopathological features with pathophysiologic correlations

2021 ◽  
Vol 6 (3) ◽  
pp. 211-215
Author(s):  
Sanpreet Singh Sachdev ◽  
Yogita Bhaginath Adhane ◽  
Manisha Ahire Sardar ◽  
Tabita Joy Chettiankandy ◽  
Sarang Gautam Sonawane
Keyword(s):  
Connective Tissue ◽  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Survival Rates ◽  
Clinical Manifestations ◽  
Response To Treatment ◽  
Transformation Rate ◽  
Histopathological Features ◽  
Potentially Malignant ◽  
Submucous Fibrosis

Oral submucous fibrosis (OSMF) is a potentially malignant disorder characterized by juxtaepithelial inflammation and progressive fibrosis of submucosal tissues. It may affect any part of the oral cavity, as well as pharynx and oesophagus. The pathogenesis of OSMF may be attributable to habitual chewing of areca nut and its products, which is more prevalent amongst young population of South East Asia and India. Various histopathological features in different tissue components- epithelial, connective tissue stroma, muscle and salivary gland may be observed along the course of this chronic disorder. In connective tissue, extensive fibrosis with progressive hyalinization of collagen fibers and muscles accompanied by inflammatory response is considered to be pathognomonic feature. Advanced stages of OSMF may show atrophic changes or even dysplasia in the epithelium which may undergo malignant transformation. Malignant transformation rate of OSMF has been proved to be around 7.5%. Thus, identification of early histopathological changes in OSMF can lead to improved survival rates. The present article illustrates the various histopathological features observed during different stages of development of OSMF. A better understanding of the correlation between histopathological features and corresponding clinical manifestations can aid dental surgeons in prognostication of the lesion and determining response to treatment.

Malignant transformation rate in oral submucous fibrosis over a 17-year period

1985 ◽  
Vol 13 (6) ◽  
pp. 340-341 ◽  
Author(s):  
P.R. Murti ◽  
R.B. Bhonsle ◽  
J. J. Pindborg ◽  
D.K. Daftary ◽  
P.C. Gupta ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Transformation Rate ◽  
Submucous Fibrosis

scholarly journals Coetaneous Presentation of Oral Leukoplakia and Oral Submucous Fibrosis with High Grade Dysplasia and Its Management with Lasers: A Case Report

2021 ◽  
Vol 6 (08) ◽  
pp. 464-469
Author(s):  
Preethi R ◽  
Malarkodi T ◽  
Arvind Krishnamurthy ◽  
Aravind Warrier S
Keyword(s):  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Oral Leukoplakia ◽  
High Grade Dysplasia ◽  
High Grade ◽  
Oral Potentially Malignant Disorders ◽  
Oral Epithelial Dysplasia ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Submucous Fibrosis

Oral potentially malignant disorders (OPMD) are diverse lesions associated with an increased likelihood for malignant transformation to oral cancer. The most frequently encountered OPMD in clinical practice are Oral Leukoplakia and oral submucous fibrosis (OSMF). The use of tobacco is consistently linked with leukoplakia and areca/betel nut with OSMF. Histopathological features of oral epithelial dysplasia, its varying grades are of immense clinical significance to evaluate its ability for malignant transformation. We report a case of homogenous leukoplakia and OSMF, two oral potentially malignant disorders occurring at the same site with high-grade dysplasia and its management using lasers.

Influence of Risk Habits on Demographic Factors and its Impact on Oral Submucous Fibrosis

2021 ◽  
Vol 15 (11) ◽  
pp. 3058-3061
Author(s):  
Shahrayne Rashid ◽  
Saadia Manzar ◽  
Farhat Kazmi ◽  
Hazik Bin Shahzad ◽  
Zeeshan Aslam Jan ◽  
...  
Keyword(s):  
Paradigm Shift ◽  
Oral Submucous Fibrosis ◽  
Tertiary Care ◽  
Mouth Opening ◽  
Cross Sectional Study ◽  
Control Measures ◽  
Significant Finding ◽  
Areca Nut ◽  
Cross Sectional ◽  
Submucous Fibrosis

Objective: To establish a correlation and evaluate paradigm shift of demographic parameters in oral submucous fibrosis patients due to use of areca nut and tobacco. Study Design: Cross sectional study. Place and Duration of the Study: Outpatient Department of Tertiary Care Teaching Hospital, Lahore from 1st November 2019 to 30th June 2021. Methodology: All patients with compliant of limited mouth opening and diagnosed clinically with oral submucous fibrosis were included. Biographical data was collected based on age, gender, literacy rate, socioeconomic conditions and habit of consumption of areca nut-based products and tobacco. Results: Prevalence of OSMF was 0.45% with mean age of 29.26±14.12 years. Areca nut alone is consumed more by females (44.12%) whereas combination of tobacco and areca nut use was higher in males (87.76%). Risk habits were found to be highest in uneducated/primary education (63.01%) and in low socioeconomic group (59.03%). Conclusion: Comparing the last two decades, there is paradigm shift in age of contracting OSMF towards younger age. Significant finding of areca nut use by females also draws attention for control measures. Harmful effects of areca nut and tobacco products should be highlighted and included in educational and community programs. Keywords: Oral submucous fibrosis, Potentially malignant disorders, Areca nut, Oral squamous cell carcinoma

an Role of Yashtimadhu Siddha Til Tail Kawalgriha in the Management of Oral submucous fibrosis.(osmf)

2020 ◽  
Vol 8 (05) ◽  
Author(s):  
GOVIND VITTHALRAO SHINDE Shinde
Keyword(s):  
Buccal Mucosa ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Control Group ◽  
Trial Group ◽  
Eligibility Criteria ◽  
Mandibular Incisor ◽  
Chronic Inflammatory Condition ◽  
Cheap Alternative ◽  
Submucous Fibrosis

ABSTRACT Oral submucous fibrosis (Osmf) is a chronic inflammatory condition of buccal mucosa with fibrosis,& restricted mouth opening(trismus) characterized by discoloration of buccal mucosa, intolerance to spicy foods& recurrent episodes of stomatitis.it is common in young population having the chewing habits of gutkha, pan masala, tobacco etc. It makes patients life miserable.  As it is a precancerous condition it seeks attention towards this disease. Medical treatments with minor surgical options are available with unsatisfactory results. This study was aimed at finding the safe, effective & cheap alternative remedy of osmf. This study conducted on 60 diagnosed cases of osmf fulfilling eligibility criteria randomly divided in two groups trial group 30 treated with yashtimadhu siddha til tail& control group 30 treated with til tail+saindhav kavalgriha4 for one month with weekly follow-ups .Results in both the groups were encouraging with minimal differences, mouth opening capacity & increased tolerance to spicy foods were the more appreciable results found in trial group. To get more results intervention can be extended for more periods. Before & after mouth opening capacity inter Dental distance between central maxillary & mandibular incisor teeth’s  by venire caliper, along with color of buccal mucosa, pliability of mucosa, cheek retraction& tolerance to spices were assessed for the outcome of treatments in both the Groups. Keywords- OSMF, Fibrosis, Kawal Griha, Siddha tail ABSTRACT Oral submucous fibrosis (Osmf) is a chronic inflammatory condition of buccal mucosa with fibrosis,& restricted mouth opening(trismus) characterized by discoloration of buccal mucosa, intolerance to spicy foods& recurrent episodes of stomatitis.it is common in young population having the chewing habits of gutkha, pan masala, tobacco etc. It makes patients life miserable.  As it is a precancerous condition it seeks attention towards this disease. Medical treatments with minor surgical options are available with unsatisfactory results. This study was aimed at finding the safe, effective & cheap alternative remedy of osmf. This study conducted on 60 diagnosed cases of osmf fulfilling eligibility criteria randomly divided in two groups trial group 30 treated with yashtimadhu siddha til tail& control group 30 treated with til tail+saindhav kavalgriha4 for one month with weekly follow-ups .Results in both the groups were encouraging with minimal differences, mouth opening capacity & increased tolerance to spicy foods were the more appreciable results found in trial group. To get more results intervention can be extended for more periods. Before & after mouth opening capacity inter Dental distance between central maxillary & mandibular incisor teeth’s  by venire caliper, along with color of buccal mucosa, pliability of mucosa, cheek retraction& tolerance to spices were assessed for the outcome of treatments in both the Groups.  

scholarly journals Comparative Study of Intralesional Dexamethasone Plus Hyaluronidase & Oral Colchicine in Patients with Oral Submucous Fibrosis

2018 ◽  
Vol 14 (2) ◽  
pp. 60-65
Author(s):  
Ganesh Prasad Neupane ◽  
Maya Rai ◽  
R. S. Rathore ◽  
V. K. Bhargava ◽  
A. K. Mahat ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Oral Mucosa ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Study Groups ◽  
T Test ◽  
Significant Difference ◽  
Intralesional Injections ◽  
Submucous Fibrosis ◽  
Larger Sample

Introduction: Oral Submucous Fibrosis (OSMF) is a precancerous condition of the oral mucosa. It is characterized by excessive production of collagen leading to inelasticity of the oral mucosa and atrophic changes of the epithelium.Aim and objective: To evaluate the efficacy of oral Colchicine in comparison to intralesional injections of Dexamethasone plus Hyaluronidase in the management of OSMF patients.Materials and Methods: Fourty patients with OSMF were randomly divided equally into two groups. 20 patients in Dexamethasone group received biweekly intralesional injections of Dexamethasone (4mg/ml) plus Hyaluronidase 1500 IU in buccal mucosa for a period of 12 weeks. Other 20 patients in Colchicine group received oral Colchicine 0.5 mg tablets twice daily for 12 weeks. Parameters taken in the study were burning sensation, and mouth opening. Descriptive statistics, paired t test and unpaired t test were used for statistical analysis.Results and Conclusions: The pre- and post-treatment differences were found to be statistically significant for both the groups (p<0.001) and for both the treatment outcomes. When the average difference of the treatment outcomes was compared between the two study groups, statistically highly significant difference was noted (p <0.001) only in mouth opening but not in burning sensation.These encouraging results should prompt further clinical trials with Colchicine on a larger sample size to broaden the therapeutic usefulness of the drug in the management of OSMF. JNGMC,  Vol. 14 No. 2 December 2016, Page: 60-65

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