scholarly journals The use of angiotensin receptor blocker losartan in the combinational therapy of arterial hypertension

2009 ◽  
Vol 6 (4) ◽  
pp. 12-15
Author(s):  
N Sh Zagidullin ◽  
Sh Z Zagidullin
Keyword(s):  
Cardiovascular Risk ◽  
Combination Therapy ◽  
Arterial Hypertension ◽  
Resistant Hypertension ◽  
Angiotensin Receptor Blocker ◽  
High Efficiency ◽  
Combined Therapy ◽  
Angiotensin Receptor ◽  
High Cardiovascular Risk ◽  
Combinational Therapy

Blockade of renin-angiotensin systems is one problem in the treatment of arterial hypertension. Resistant hypertension and patients with high cardiovascular risk demand frequently use of combination therapy. The efficiency of combined therapy losartan plus hydrochlorothiazide at patients with arterial hypertension was studied in several large clinical multicentre randomized studies. It is proved high efficiency and safety of this combination therapy.

scholarly journals Combined Therapy of Arterial Hypertension. The Opinion of a Clinical Pharmacologist

2020 ◽  
Vol 16 (4) ◽  
pp. 601-606
Author(s):  
M. V. Zhuravleva ◽  
E. V. Luchinina ◽  
T. V. Shelekhova ◽  
S. Yu. Serebrova ◽  
S. A. Belkov ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Arterial Hypertension ◽  
High Efficiency ◽  
Patient Adherence ◽  
Combined Therapy ◽  
Angiotensin Ii Receptor Blocker ◽  
Angiotensin Ii Receptor ◽  
Converting Enzyme Inhibitors ◽  
Hypertensive Patients ◽  
Risk Patients

Modern tactics of treatment of arterial hypertension (AH) involves the use of both monotherapy and combination therapy. Monotherapy is recommended primarily for low-risk patients with systolic blood pressure (BP)< 150 mm Hg. Monotherapy should also be preferred in very high risk patients with high normal BP and frail elderly patients. However, combination therapy is recommended for most hypertensive patients as initial therapy. Starting combination therapy is more effective in lowering BP than monotherapy. Even at low doses, it is usually more effective than maximum dose monotherapy. The most commonly prescribed combinations today contain a renin-angiotensin system blocker (angiotensin converting enzyme inhibitors or angiotensin II receptor blocker) with a calcium antagonist or diuretic. The combination of lisinopril with amlodipine not only proved its high efficiency in various international and Russian studies, but also turned out to be pharmacoeconomically more profitable. Fixed combinations of lisinopril and amlodipine are the optimal choice in the treatment of hypertensive patients, due to all the advantages of both components: higher efficacy and safety rates compared to monotherapy and better patient adherence to treatment.

scholarly journals Effect of Dual Blockade of Renin-Angiotensin System on Proteinuria

2013 ◽  
Vol 1 (1) ◽  
pp. 18-20
Author(s):  
Eqerem Hasani ◽  
Alma Idrizi ◽  
Myftar Barbullushi
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Angiotensin Receptor Blocker ◽  
Enzyme Inhibitor ◽  
Combined Therapy ◽  
Renin Angiotensin System ◽  
Converting Enzyme ◽  
Angiotensin Receptor ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Dual Blockade

Aim: Aim of the study was the evaluation of the effect of dual blockade of the renin-angiotensin system (RAS) on proteinuria. Material and Methods: Sixty patients, included in the study, were treated with angiotensin-converting enzyme inhibitor and angiotensin receptor blocker for a period of 3 months. Results: The dual blockade of RAS resulted with decrease of proteinuria, a slight increase of serum creatinine and was not associated with a lowering of blood pressure.Conclusion: Combined therapy with ACE-I and ARB results in a more complete blockade of the RAS than monotherapy. In proteinuric nephropathies it reduces significantly baseline proteinuria.

scholarly journals Modern Hypolipidemic Therapy in Patients with Arterial Hypertension with High Cardiovascular Risk Under Conditions of Long-Term Ambulatory Observation

2020 ◽  
Vol 12 (14) ◽  
pp. 68-72
Author(s):  
Ruziyeva Amira Asrorovna ◽  
Muradova Railya Rustamovna ◽  
Turaev Khikmatulla Negmatovich ◽  
Nuralieva Rano Matyakubovna
Keyword(s):  
Cardiovascular Risk ◽  
Arterial Hypertension ◽  
High Cardiovascular Risk

scholarly journals Rational combination therapy in resistant arterial hypertension

2011 ◽  
Vol 17 (4) ◽  
pp. 384-390
Author(s):  
I. V. Emelianov ◽  
A. O. Konradi
Keyword(s):  
Combination Therapy ◽  
Arterial Hypertension ◽  
Resistant Hypertension ◽  
Drug Resistant ◽  
Therapeutic Approaches ◽  
Rational Combination ◽  
Resistant Arterial Hypertension

The article reviews therapy in drug-resistant hypertension. Current therapeutic approaches to treatment and rational combination therapy are discussed.

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