scholarly journals NEUROTROPIC ACTIVITY OF PLANT ALKALOIDS

2021 ◽  
Vol 88 (3) ◽  
Author(s):  
R. B. Seydakhmetova ◽  
K.D. Rakhimov ◽  
D.S. Tutay ◽  
T.T. Mukhanova ◽  
А. А. Zholbarys ◽  
...  
Keyword(s):  
Neurotropic Activity ◽  
Plant Alkaloids

Effect of Some Metabolic Inhibitors on Vinblastine-Induced Ribosomal-Granular Material Complexes

1971 ◽  
Vol 29 ◽  
pp. 548-549
Author(s):  
Awtar Krishan ◽  
Dora Hsu
Keyword(s):  
Granular Material ◽  
Rna Synthesis ◽  
Culture Medium ◽  
Actinomycin D ◽  
Metabolic Inhibitors ◽  
Protein And Rna Synthesis ◽  
Apparent Reduction ◽  
Plant Alkaloids ◽  
In Cells

Cells exposed to antitumor plant alkaloids, vinblastine and vincristine sulfate have large proteinacious crystals and complexes of ribosomes, helical polyribosomes and electron-dense granular material (ribosomal complexes) in their cytoplasm, Binding of H3-colchicine by the in vivo crystals shows that they contain microtubular proteins. Association of ribosomal complexes with the crystals suggests that these structures may be interrelated.In the present study cultured human leukemic lymphoblasts (CCRF-CEM), were incubated with protein and RNA-synthesis inhibitors, p. fluorophenylalanine, puromycin, cycloheximide or actinomycin-D before the addition of crystal-inducing doses of vinblastine to the culture medium. None of these compounds could completely prevent the formation of the ribosomal complexes or the crystals. However, in cells pre-incubated with puromycin, cycloheximide, or actinomycin-D, a reduction in the number and size of the ribosomal complexes was seen. Large helical polyribosomes were absent in the ribosomal complexes of cells treated with puromycin, while in cells exposed to cycloheximide, there was an apparent reduction in the number of ribosomes associated with the ribosomal complexes (Fig. 2).

Comparative Study of the Biologically Active Substances Composition and Content in Meadowsweet (Filipendula ulmaria (L.) Maxim) Crude Herbal Drugs (Herb, Leafs, Flowers) of Russian Origin

2018 ◽  
Vol 9 (3) ◽  
Author(s):  
Dmitry Olegovich Bokov ◽  
Tatyana Yuryevna Kovaleva ◽  
Valentina Alekseevna Ermakova ◽  
Daria Aleksandrovna Trashchenkova ◽  
Ekaterina Anatolievna Dorovskih ◽  
...  
Keyword(s):  
Traditional Medicine ◽  
Neurotropic Activity ◽  
Comparative Investigation ◽  
Biologically Active ◽  
Total Flavonoids ◽  
Herbal Drugs ◽  
Filipendula Ulmaria ◽  
Pharmacopoeial Monograph ◽  
Total Extractives ◽  
Layer Chromatography

Filipendula ulmaria (L.) Maxim. (Meadowsweet) is known in traditional medicine as anti-inflammatory, wound-healing,astringent and antibacterial remedy. However recent studies show that it also has neurotropic activity. In Russia meadowsweet flowers are used as crude herbal drugs (temporary pharmacopoeial monograph 42-1777-87), also leafs and herb are used in the traditional medicine. Objective of the study was to carry out comparative investigation of composition and content of major biologically active compounds (BAC) in Filipendula ulmaria herb, flowers and leafs by thin-layer chromatography, differential spectrophotometry with aluminum chloride reagent (total flavonoids in terms of rutoside), gravimetry (total extractives, extracted by water), permanganatometric titration (total tannins in terms of tannin). Rutoside, tannin, gallic acid and salicylic acid were identified in Filipendula ulmaria herb, flowers and leafs by TLC. Also we analyzed content of substances extracted by water, flavonoids and tannins. Total extractives, extracted by water in F. ulmaria herb is 13.12±0.10%, in leafs – 13.98±0.37%, in flowers – 18.09±0.17%. Total tannins in F. ulmaria herb is 11.87±0.47%, in leafs – 12.06±0.18%, in flowers – 12.26±0.29%. Total flavonoids in F. ulmaria herb 4.34±0.17%, in leafs – 6.98±0.23%, in flowers – 11.75±0.57%. The obtained data will be used for development of a pharmacopoeial monograph project "Filipendula ulmaria (L.) Maxim., herba" for inclusion in the State Pharmacopoeia of the Russian Federation.

scholarly journals Self-assembly of Quaternary Benzo[c]phenanthridine Plant Alkaloids into Dimer in Aqueous Solution

2021 ◽  
pp. 116014
Author(s):  
Zsombor Miskolczy ◽  
Mónika Megyesi ◽  
György Lendvay ◽  
László Biczók
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Plant Alkaloids

scholarly journals Potential of plant alkaloids as dengue ns3 protease inhibitors: Molecular docking and simulation approach

2014 ◽  
Vol 9 (3) ◽  
Author(s):  
Muhammad Tahir Ul Qamar ◽  
Arooj Mumtaz ◽  
Usman Ali Ashfaq ◽  
Muhammad Muzammal Adeel ◽  
Tabeer Fatima
Keyword(s):  
Molecular Docking ◽  
Protease Inhibitors ◽  
Simulation Approach ◽  
Ns3 Protease Inhibitors ◽  
Plant Alkaloids ◽  
Ns3 Protease

Cytotoxicity and cell cycle effects of the plant alkaloids cryptolepine and neocryptolepine: relation to drug-induced apoptosis

2000 ◽  
Vol 409 (1) ◽  
pp. 9-18 ◽  
Author(s):  
Laurent Dassonneville ◽  
Amélie Lansiaux ◽  
Aurélie Wattelet ◽  
Nicole Wattez ◽  
Christine Mahieu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Drug Induced ◽  
Plant Alkaloids ◽  
Induced Apoptosis

scholarly journals Synthesis, neurotropic activity and SAR of new S-alkyl derivatives of 8-pyrazol-1-yl pyrano[3,4-c]pyridines

ARKIVOC ◽  
2022 ◽  
Vol 2022 (2) ◽  
Author(s):  
Shushanik Shamir Dashyan ◽  
Ruzanna Garnik Paronikyan ◽  
Suren Sergey Mamyan ◽  
Ervand Garnik Paronikyan
Keyword(s):  
Neurotropic Activity ◽  
Alkyl Derivatives ◽  
Derivatives Of

Synthesis and neurotropic activity of N-D-pantothenoyl-γ-aminobutyric acid and mixed-ligand compounds of metals with D-pantothenic and γ-aminobutyric acids

1983 ◽  
Vol 17 (1) ◽  
pp. 32-36
Author(s):  
Ya. D. Fridman ◽  
Dzh S. Sarbaev ◽  
N. M. Kebets ◽  
V. M. Kopelevich ◽  
L. N. Bulanova ◽  
...  
Keyword(s):  
Neurotropic Activity ◽  
Mixed Ligand ◽  
Aminobutyric Acid
Sign in / Sign up

Export Citation Format

Share Document