Comparative Characteristics of the Effectiveness of Treating Chronic Cholecystitis, Techanical Jaundice and Chronic Pancreatitis Using Biochemical Tests

SummaryThe biochemical values of 76 patients with suspected cholecystitis were subjected to discriminant analysis. The final diagnoses, i. e. acute cholecystitis, chronic cholecystitis and non-biliary disease, were used as the grouping variable. Cholescintigraphy identified patients with acute cholecystitis. Routine preoperative biochemical tests were found to be of limited value. Only alkaline phosphatase was of help in predicting common-duct stones, especially in patients with acute cholecystitis. The conclusion is that many biochemical tests presently in common use could as well be dispensed with.

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Biochemical tests in the diagnosis of chronic pancreatitis and in the evaluation of pancreatic insufficiency

Clinical Biochemistry ◽

10.1016/0009-9120(93)90124-o ◽

1993 ◽

Vol 26 (4) ◽

pp. 253-275 ◽

Cited By ~ 14

Author(s):

David M. Goldberg ◽

Peter R. Durie

Keyword(s):

Chronic Pancreatitis ◽

Pancreatic Insufficiency ◽

Biochemical Tests

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A STUDY OF THE CORRELATION BETWEEN HISTOPATHOLOGICAL EXAMINATION OF THEHEPATOBILIARY TISSUE WITH SERUM ALANINE AMINOTRANSFERASE AND ALKALINE PHOSPHATASE

International Journal of Advanced Research ◽

10.21474/ijar01/12295 ◽

2021 ◽

Vol 9 (01) ◽

pp. 196-199

Author(s):

Kalpesh Gupta ◽

◽

Adil Rahman ◽

Shailendra Pal Singh ◽

Roopak Aggarwal ◽

...

Keyword(s):

Bone Growth ◽

Histopathological Examination ◽

Pathological Condition ◽

Tertiary Care ◽

Uttar Pradesh ◽

Quality Standard ◽

Chronic Cholecystitis ◽

Care Hospital ◽

Biochemical Tests ◽

Mean Values

Background: Several biochemical tests are useful in the evaluation and management of patients with hepatic dysfunction.These tests can be used to detect the presence of liver disease, distinguish among different types of liver disorders, gauge the extent of known liver damage, and follow the response to treatment.ALT reflects damage to hepatocytes and it is found primarily in liver in low concentrations and get released into the blood in greater amount when there is damage to liver cell membrane resulting in increased permeability.The activity of ALP in a pathological condition is usually elevated in cholestasis.Non-pathologically it is also elevated in children and adolescents undergoing rapid bone growth and in late pregnancy.The main objective of this study was to correlate these serum biomarkers with the histopathological reports of the resected gallbladder specimen. Methodology: This study was conducted prospectively on 493 patients in a tertiary care hospital in eastern Uttar Pradesh (India).In year 2019, from January to December, patients admitted for cholecystectomy in surgery ward of this hospital were included in this study.After surgery, about 3-4 ml of the blood sample was obtained and analyzed in the biochemistry laboratory after proper control and calibration, meeting the quality standard of the laboratory.Results thus obtained were correlated with the histopathological report of the gallbladder specimen provided by the pathology department of the institute. Results: In our study, out of 493 patients it was observed that 70 (14.2%) patients were males with mean age of 39.6 years and 423 (85.8%) patients were females with mean age of 37.6 years.Chronic cholecystitis with cholelithiasis was reported in 284 (57.6%) patients with mean values of serum ALT as 79.9 IU/L and serum ALP as 263.9 IU/L.Chronic cholecystitis was reported in 79 (16%) patients with mean values of serum ALT as 59.1 IU/L and serum ALP as 228.1 IU/L. Conclusion: From our study, we concluded that in patients of chronic cholecystitis with cholelithiasis, observed values of serum ALT and serum ALP were much higher than in chronic cholecystitis.

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The Value of Routine Biochemical Tests in Discriminating Between Malignant and Benign Pancreatic Tumours

HPB Surgery ◽

10.1155/1991/17956 ◽

1991 ◽

Vol 4 (2) ◽

pp. 147-155 ◽

Cited By ~ 1

Author(s):

L. Athlin ◽

P-J Blind ◽

S. Eriksson

Keyword(s):

Alkaline Phosphatase ◽

Chronic Pancreatitis ◽

Discriminant Analysis ◽

Pancreatic Carcinoma ◽

Predictive Value ◽

Laboratory Tests ◽

Total Bilirubin ◽

Lactic Dehydrogenase ◽

Biochemical Tests ◽

Pancreatic Tumours

The probability that routine hematological laboratory tests of liver and pancreatic function can discriminate between malignant and benign pancreatic tumours, incidentally detected during operation, was investigated. The records of 53 patients with a verified diagnosis of pancreatic carcinoma and 19 patients with chronic pancreatitis were reviewed with regard to preoperative total bilirubin, direct reacting bilirubin, alkaline phosphatase, glutamyltranspeptidase, aminotransferases, lactic dehydrogenase and amylase. Multivariate and discriminant analysis were performed to calculate the predictive value for cancer, using SYSTAT statistical package in a Macintosh II computer. Total and direct reacting bilirubin and glutamyltranspeptidase were significantly higher in patients with pancreatic carcinoma. However, only considerably increased levels of direct reating bilirubin were predictive of pancreatic carcinoma.

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