Deterioration of quality of life in patients with chronic pancreatitis

Objective We aimed to describe the clinical characteristics of chronic pancreatitis (CP) and patient quality of life (QOL) in a resource-limited setting. Methods We performed a cross-sectional study including patients with clinical and radiological features of CP. We collected clinical data and assessed QOL using the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire. Results We included 103 patients (median age 44 years, 84 men). Median age at symptom onset was 36 (4–78) years. Around 70% of patients had diabetes mellitus and 62.1% had consumed alcohol; 36 (35%) were current smokers. The mean overall global QOL score was 68.7. Most patients (91.3%) sought treatment from multiple centers. Nineteen (18.5%) had pancreatic stone disease, 38 (36.9%) had persistent abdominal pain (median severity 7.8/10, 59 (57.3%) had steatorrhea, and 56 (54.4%) had jaundice. Poor QOL was significantly associated with weight loss, loss of appetite, and intractable pain. No correlation with age, sex, or alcohol consumption was noted. Conclusion A considerable proportion of patients with CP had troublesome symptoms. Intractable pain, loss of appetite, and weight loss were significantly associated with poor QOL. Further assessment is needed of patients’ psychosocial well-being and its association with QOL.

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Strengthening the pharmacological potential of drug therapy in treatment of patients with chronic pancreatitis by using therapeutic physical factors

Fizioterapevt (Physiotherapist) ◽

10.33920/med-14-2012-01 ◽

2020 ◽

pp. 8-14

Author(s):

R. M. Mallaeva ◽

A. N. Makhinko ◽

M. B. Uzdenov

Keyword(s):

Quality Of Life ◽

Chronic Pancreatitis ◽

Drug Therapy ◽

Clinical Manifestations ◽

Medical Rehabilitation ◽

Control Group ◽

Physical Factors ◽

Standard Drug ◽

Pharmacological Potential

The purpose of the study is to improve rehabilitation treatment of patients with chronic pancreatitis (CP) at inpatient stage by strengthening pharmacological potential of drug therapy due to inclusion of therapeutic physical factors (TPF) in therapeutic programs. Materials and methods. 159 patients with acute CP were observed. By simple randomization, 4 groups were formed: the control group (MG, 39 people) received standard drug therapy; 1st comparison group (GC1; 38 people) additionally received TPF; GC2 (40 people) in addition to treatment in GC1 had drinking mineral water «Slavyanovskaya»; in main group (42 people) in addition to the treatment in GC2 got preformed peloidotherapy on the cervical-collar zone. All the patients underwent the evaluation of clinical score and quality of life before and after medical rehabilitation. Results. In MG, clinical symptomatology leveling was by 78,2% (p<0,01), in GC1 — by 71,5% (p<0,01), GC2 — by 62,3% (p<0,01), CG — by 57,2% (p<0,01) on average immediately after the treatment, which was in a clear correlation with indicators of quality of life. In the long term (in 6 and 12 months), the advantage of combination therapy was noted with the same validity, the preservation of the achieved positive result was mostly noted in the MG: after 6 months the improvement in physical health compared to the initial values was noted by 34,4% (p<0,01), after 12 months — by 24,0% (p<0,05); mental — by 32,3% (p<0,01) and 22,5% (p<0,05), respectively. In both comparison groups, positive dynamics was 10–12% lower, and in the control group, after 6 months, there was only a tendency to improve quality of life indicators. Conclusion. The inclusion of TPF in the programs of the inpatient stage of medical rehabilitation of patients with chronic pancreatitis by strengthening the pharmacological potential of drug therapy contributes to the leveling of clinical manifestations (abdominal pain, dyspepsia and diarrhea), the result of which is an improvement in the quality of life of this category of patients.

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QUALITY OF LIFE IN PATIENTS WITH CHRONIC PANCREATITIS IN THE MOSCOW REGION

Almanac of Clinical Medicine ◽

10.18786/2072-0505-2015-40-64-71 ◽

2016 ◽

pp. 64-71

Author(s):

S. V. Belyakova ◽

E. A. Belousova

Keyword(s):

Quality Of Life ◽

Chronic Pancreatitis ◽

Moscow Region

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Quality of life comparison in chronic pancreatitis patients: A case-control study

Pancreatology ◽

10.1016/j.pan.2015.05.257 ◽

2015 ◽

Vol 15 (3) ◽

pp. S68 ◽

Cited By ~ 1

Author(s):

Samuel Han ◽

Yoel Carrasquillo ◽

Julien Fahed ◽

Joan Kheder ◽

Wahid Wassef

Keyword(s):

Quality Of Life ◽

Chronic Pancreatitis ◽

Case Control Study ◽

Case Control ◽

Control Study

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A Modern Review of the Operative Management of Chronic Pancreatitis

The American Surgeon ◽

10.1177/000313481007601010 ◽

2010 ◽

Vol 76 (10) ◽

pp. 1071-1074 ◽

Cited By ~ 4

Author(s):

Jonathan C. King ◽

Shannon Abeywardina ◽

James J. Farrell ◽

Howard A. Reber ◽

O. Joe Hines

Keyword(s):

Quality Of Life ◽

Chronic Pancreatitis ◽

Short Form ◽

Operative Management ◽

Poor Quality ◽

Whipple Procedure ◽

Life Questionnaire ◽

Historical Controls

Chronic pancreatitis is a debilitating disease resulting in pain, intestinal malabsorption, endocrine dysfunction, and poor quality of life (QoL). Our aim was to analyze surgical outcomes for patients with chronic pancreatitis. Data for patients undergoing operations for chronic pancreatitis between 1990 and 2009 were reviewed. Demographics, operative and perioperative data, and survival were catalogued. QoL was determined (Short Form 36 and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire + PAN-26) and compared with historical controls. The mean age was 51 ± 2 years, 38 patients were male (53%), the most common indication was pain (71%), the etiology of pancreatitis often was alcohol, and most patients underwent a Whipple procedure (56%). Operative time was 316 ± 17 minutes and blood loss was 363 ± 75 mL. There were 34 complications in 30 patients (42%) and one death. QoL surveys were administered for 25 of 55 (45%) surviving patients at a mean follow-up of 72 ± 16 months. Mean survival was 99 ± 9 months, whereas 5- and 10-year survival were 86 and 75 per cent. QoL scores were uniformly better than historical controls. Our data demonstrate that operations for chronic pancreatitis can be performed with acceptable morbidity and mortality. Patients have excellent survival and improved QoL compared with historical controls. Surgery is an effective and durable treatment option for patients with chronic pancreatitis.

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