scholarly journals taphylococcus aureus as a paradiagm of a persistent problem of bacterial multiple antibiotic resistance in Abha, Saudi Arabia

2000 ◽  
Vol 6 (5-6) ◽  
pp. 948-954
Author(s):  
N. E. Bilal ◽  
M. Gedebou
Keyword(s):  
Staphylococcus Aureus ◽  
Saudi Arabia ◽  
Antibiotic Resistance ◽  
Maternity Hospital ◽  
Microbiology Laboratory ◽  
Multiple Antibiotic Resistance ◽  
Methicillin Resistant ◽  
Persistent Problem ◽  
Resistance Patterns

We reviewed the microbiology laboratory records of Abha Maternity Hospital, Saudi Arabia for 1996 and 1998 to assess multiple antibiotic resistance, using Staphylococcus aureus as a paradigm. A total of 587 and 485 strains were isolated in 1996 and 1998 respectively. In 1996, over 60.0% were resistant to five of the nine antibiotics tested; in 1998, over 55.0% were resistant to six antibiotics. In both years, 71.0% were methicillin-resistant S. aureus. Over 85.0% of all strains were multiresistant. Although over 100 types of resistance patterns were detected, more than half of the strains displayed fewer than 15 types. The strains most frequently isolated were considered hospital strains, which accounted for most infections.

scholarly journals An outbreak of methicillin resistant Staphylococcus epidermidis among neonates in a hospital in Saudi Arabia

2011 ◽  
Vol 5 (10) ◽  
pp. 692-699 ◽  
Author(s):  
Maha Abd El Hafez ◽  
Noha G. Khalaf ◽  
Mohamed El Ahmady ◽  
Ahmed Abd El Aziz ◽  
Abd El Gawad Hashim
Keyword(s):  
Saudi Arabia ◽  
Antibiotic Resistance ◽  
Staphylococcus Epidermidis ◽  
Neonatal Intensive Care ◽  
Meca Gene ◽  
Neonatal Intensive Care Units ◽  
Methicillin Resistant ◽  
Resistance Patterns ◽  
Clonal Origin ◽  
Resistance Rates

Introduction: Staphylococcus epidermidis is a pathogen associated with nosocomial infection in neonatal intensive care units (NICU). This study investigates an outbreak of methicillin resistant S. epidermidis in an NICU in a hospital in Saudi Arabia. Methodology: A total of 41 isolates identified as Gram-positive cocci were obtained from blood culture, umbilical wound swabs and endotracheal aspirate specimens of neonates, of which 29 were identified as S. epidermidis. Bacterial identification at the species level and determination of antibiotic resistance were performed by MicroScan (Dade Behring, USA). Genotyping was completed using randomly amplified polymorphic DNA (RAPD) and the mecA gene was detected by PCR. Results: All 29 S. epidermidis isolates were found to be resistant to oxacillin and were positive for the mecA gene. The isolates showed several multidrug-resistance patterns; the resistance rates to gentamicin, erythromycin, clindamycin, and trimethoprim/sulfamethoxazole were 89.7%, 86.2%, 75.9% and 72.4%, respectively. All isolates were susceptible to vancomycin, teicoplanin, rifampin, synercid, and ciprofloxacin. Several genotypic and phenotypic patterns were detected among the S. epidermidis isolates: antibiogram typing showed seven different patterns, one of which was shared by 65% of the isolates, whereas the most prevalent RAPD genotype was shared by only five S. epidermidis isolates, and did not correlate with antibiotic resistance phenotype. Conclusion: The diverse clonal origin of tested isolates indicates the presence of multiple S. epidermidis strains among neonates in the NICU setting

scholarly journals Methicillin-Resistant Staphylococcus aureus ST80 Clone: A Systematic Review

Toxins ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 119 ◽  
Author(s):  
Assia Mairi ◽  
Abdelaziz Touati ◽  
Jean-Philippe Lavigne
Keyword(s):  
Systematic Review ◽  
Staphylococcus Aureus ◽  
Antibiotic Resistance ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Sampling Period ◽  
Spa Typing ◽  
Methicillin Resistant ◽  
Resistance Patterns ◽  
Mrsa Strains ◽  
Spa Type

This review assessed the molecular characterization of the methicillin-resistant Staphylococcus aureus (MRSA)-ST80 clone with an emphasis on its proportion of total MRSA strains isolated, PVL production, spa-typing, antibiotic resistance, and virulence. A systematic review of the literature was conducted on MRSA-ST80 clone published between 1 January 2000 and 31 August 2019. Citations were chosen for a review of the full text if we found evidence that MRSA-ST80 clone was reported in the study. For each isolate, the country of isolation, the sampling period, the source of isolation (the type of infection, nasal swabs, or extra-human), the total number of MRSA strains isolated, number of MRSA-ST80 strains, antibiotic resistance patterns, PVL production, virulence genes, and spa type were recorded. The data from 103 articles were abstracted into an Excel database. Analysis of the data showed that the overall proportion of MRSA-ST80 has been decreasing in many countries in recent years. The majority of MRSA-ST80 were PVL positive with spa-type t044. Only six reports of MRSA-ST80 in extra-human niches were found. This review summarizes the rise of MRSA-ST80 and the evidence that suggests that it could be in decline in many countries.

scholarly journals Trends in antibiotic resistance patterns of methicillin resistant and methicillin sensitive Staphylococcus aureus in Khwaja Yunus Ali Medical College Hospital

KYAMC Journal ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Abdullah Akhtar Ahmed ◽  
Md Abdus Salam ◽  
Md Shakhaowat Hossain ◽  
Md Babul Aktar ◽  
Nusrat Akhtar Juyee ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Resistance ◽  
Antimicrobial Resistance ◽  
Pathogenic Bacteria ◽  
Current Status ◽  
Clinical Samples ◽  
Sensitivity Testing ◽  
Methicillin Resistant ◽  
Resistance Patterns ◽  
Antibiotic Resistance Patterns

Background: Antimicrobial resistance in pathogens is a growing concern for health. It is a great concern around the globe about the threat of increasing antimicrobial resistance. In response to this concerns, medical experts have proposed initiatives to curtail the spread of antimicrobial resistance in pathogenic bacteria. We have taken this surveillance study in KYAMCH to contain the spread of antimicrobial resistance.Objectives: To determine the prevalence of MRSA from different clinical samples and to record its current status to commonly used anti Staphylococcus antibiotics.Methods: The clinical samples were taken to the laboratory and within four hours cultured for isolates and identification pathogens. Finally, antibiotic sensitivity testing of the isolated Staphylococcus aureus was performed. Results: More than 80% of MRSA isolates were resistant to ampicillin (98%) followed by amoxicillin, cefixime and azithromycin with 94%, 93.5% and 85% respectively and maximum sensitivity toward tobramycin with 86% followed by 85% gentamicin and 79% meropenem.Conclusion: The detected trend in antibiotic resistance patterns of methicillin-resistant and methicillin-sensitive Staphylococcus aureus in this study is alarming. This has created a huge clinical burden in the hospital settings as well as in the community.KYAMC Journal Vol. 9, No.-1, April 2018, Page 6-10

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