Dietary total antioxidant capacity and the risk of breast cancer: a case–control study

Abstract Objective: The aim of this study was to determine the relationship between dietary total antioxidant capacity (dTAC) and risk of breast cancer among Iranian women. Design: In this hospital-based case–control study, dietary intake of participants was collected using a 168-item validated FFQ. Dietary TAC was assessed using FRAP assay considering. Logistic regression was used to obtain ORs for breast cancer across quartiles of dTAC. Setting: Cancer Institute, Iran. Participants: We included 412 women with pathologically confirmed breast cancer and 456 apparently healthy controls. Results: Mean dTAC was 11·3 ± 5·8 for cases and 12·1 ± 7·9 for controls. A trend towards significant inverse association was seen between dTAC and odds of breast cancer in the whole population; such that after controlling for several potential confounders, individuals in the highest quartile of dTAC were 0·39 times less likely to have breast cancer than those in the lowest quartile (0·61; 95 % CI: 0·38, 0·99, P < 0·05). In the stratified analysis by menopausal status, we found that postmenopausal women with the greatest dTAC had lower odds for breast cancer, compared with those with the lowest dTAC (0·47; 95 % CI: 0·24, 0·93, P < 0·05). This association strengthened after additional adjustment for BMI (0·28; 95 % CI: 0·11, 0·72, P < 0·05). No significant association was seen between dTAC and odds of breast cancer in premenopausal women. Conclusions: We found that dietary TAC was inversely associated with risk of breast cancer, in particular among postmenopausal women. Prospective cohort studies are needed to confirm these findings.

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The Association between dietary total antioxidant capacity with the risk of helicobacter pylori infection among adult: a case–control study

10.21203/rs.3.rs-26614/v1 ◽

2020 ◽

Author(s):

Mohammadhassan Sohouli ◽

Niloufar Haghshenas ◽

Somaye Fatahi

Keyword(s):

Helicobacter Pylori ◽

Antioxidant Capacity ◽

Total Antioxidant Capacity ◽

Case Control Study ◽

Case Control ◽

Antioxidant Power ◽

Total Antioxidant ◽

H Pylori ◽

Control Study ◽

Dietary Total Antioxidant Capacity

Abstract Background Dietary total antioxidant capacity (DTAC) has been assumed as a useful tool to assess the relationship between the cumulative antioxidant food capacity and several chronic disorders. The aim of this study was to evaluate the association between DTAC and risk of Helicobacter pylori in a case-control study.Methods This case-control study was carried out among 150 patients with Helicobacter pylori and 302 healthy subjects aged 18–55 years. Dietary data were collected using a validated 168- items quantitative food frequency questionnaire. DTAC was calculated based on the ferric reducing-antioxidant power (FRAP) values that reported by US Department of Agriculture. Results The mean age and BMI of the study participants were 38.70 years and 25.86, respectively. Compared with control subjects, participants with H pylori significantly were older and had higher BMI and smoking use. Patients with H pylori compared with control individuals had also lower intake of total fiber, vitamin E, vitamin C, vitamin D, total dairy, whole grain and vegetables. Compared with participants in the lowest tertile of DTAC, those in the highest terrtile had a significantly lower OR for H pylori after further adjustment for potential confounders (Model 2: OR, 0.20; 95% CI, 0.10 – 0.40; P for trend, < 0.001).Conclusions Our findings showed that a high DTAC was associated with a reduced risk of Helicobacter pylori in adult, which reflects the increased intake of natural dietary antioxidants to prevent the progression of Helicobacter pylori. However, further studies are needed to investigate the t relation between DTAC and risk of Helicobacter pylori.

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The Association between dietary total antioxidant capacity with the risk of helicobacter pylori infection among adult: a case–control study

10.21203/rs.3.rs-26732/v1 ◽

2020 ◽

Author(s):

Mohammadhassan Sohouli ◽

Niloufar Haghshenas ◽

Somaye Fatahi

Keyword(s):

Helicobacter Pylori ◽

Antioxidant Capacity ◽

Total Antioxidant Capacity ◽

Case Control Study ◽

Case Control ◽

Antioxidant Power ◽

Total Antioxidant ◽

H Pylori ◽

Control Study ◽

Dietary Total Antioxidant Capacity

Abstract Objective Dietary total antioxidant capacity (TAC) has been assumed as a useful tool to assess the relationship between the cumulative antioxidant food capacity and several chronic disorders. The aim of this study was to evaluate the association between DTAC and risk of Helicobacter pylori in a case-control study. Methods This case-control study was carried out among 150 patients with Helicobacter pylori and 302 healthy subjects aged 18–55 years. Dietary data were collected using a validated 168- items quantitative food frequency questionnaire. DTAC was calculated based on the ferric reducing-antioxidant power (FRAP) values that reported by US Department of Agriculture. Results The mean age and BMI of the study participants were 38.70 years and 25.86, respectively. Compared with control subjects, participants with H pylori significantly were older and had higher BMI and smoking use. Patients with H pylori compared with control individuals had also lower intake of total fiber, vitamin E, vitamin C, vitamin D, total dairy, whole grain and vegetables. Compared with participants in the lowest tertile of DTAC, those in the highest terrtile had a significantly lower OR for H pylori after further adjustment for potential confounders (Model 2: OR, 0.20; 95% CI, 0.10–0.40; P for trend, < 0.001). Conclusions Our findings showed that a high DTAC was associated with a reduced risk of Helicobacter pylori in adult, which reflects the increased intake of natural dietary antioxidants to prevent the progression of Helicobacter pylori. However, further studies are needed to investigate the t relation between DTAC and risk of Helicobacter pylori.

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The association between Dietary total antioxidant capacity with Rheumatoid Arthritis in adults: A case-control study

10.21203/rs.3.rs-25418/v1 ◽

2020 ◽

Author(s):

Shokufeh Nezamoleslami ◽

Saeed Nezamoleslami ◽

Reza Ghiasvand ◽

Behnoosh Boozari ◽

Mohammadhassan Sohouli

Keyword(s):

Antioxidant Capacity ◽

Total Antioxidant Capacity ◽

Case Control Study ◽

Case Control ◽

Antioxidant Power ◽

Vitamin B9 ◽

Total Antioxidant ◽

The Relationship ◽

Control Study ◽

Dietary Total Antioxidant Capacity

Abstract Objective Dietary total antioxidant capacity (TAC) has been assumed as a useful tool to assess the relationship between the cumulative antioxidant food capacity and several chronic disorders. However, the relationship between the total antioxidant capacity of the diet (TAC) and the risk of RA has not been previously examined. The aim of this study was to evaluate the association between DTAC and risk of RA in a case-control study. Methods This case-control study was carried out among 100 patients with RA and 200 healthy subjects aged 18–55 years. Dietary data were collected using a validated 147- items quantitative food frequency questionnaire. DTAC was calculated based on the ferric reducing-antioxidant power (FRAP) values that reported by US Department of Agriculture. Results The mean age and BMI of the study participants were 49.4 years and 25.6 Kg.m2.. The energy, protein, fiber, MUFA, n-3 fatty acid, vitamin B9, vegetable, and fruit were significantly increased across tertiles of DTAC. Also, Compared with participants in the lowest tertile of DTAC, those in the highest terrtile had a significantly lower OR for rheumatoid after adjustment for BMI; physical activity; waist circumference; smoking; and dietary intake energy and fat (model 3: OR, 0.19; 95% CI, 0.07–0.51; p for trend, 0.001). Conclusions Our findings showed that a high DTAC was associated with a reduced risk of RA in adult, suggesting that promoting a naturally elevated antioxidant capacity might help prevent the development of RA. Further prospective studies should be conducted in this regard.

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