STUDY OF THE DYNAMICS OF REPRODUCTION OF M. LEPRAE UNDER THE CONDITIONS OF APPLICATION OF ANISEED LOFANT EXTRACT OBTAINED FROM SUPERCRITICAL FLUID EXTRACTION METHOD

2021 ◽  
pp. 38-43
Author(s):  
Yurtaeva E.A. ◽  
Luzhnova S.A. ◽  
Tyrkov A.G.
Keyword(s):  
Supercritical Fluid Extraction ◽  
Supercritical Fluid ◽  
Blood Parameters ◽  
Term Therapy ◽  
Fluid Extraction ◽  
Bacteriostatic Effect ◽  
Drug Of Choice ◽  
High Antibacterial Activity ◽  
Long Term Therapy

One of the ways to solve the problem of drug resistance in the therapy of infectious diseases is to develop herbal preparations with high antibacterial activity, which have a good drug safety profile, is extremely significant for long-term therapy, the use of which could complement and improve the used combination therapy regimens. The aim of our study was to study the anti-leprosy activity of lofant anise extract obtained by supercritical fluid extraction using CO2 containing phenolic compounds such as gallic acid, coumarin, umbelliferon, luteolin, quercetin, taxifolin, rutin. Materials and methods. The anti-leprosy activity had been studied on Shepard's model. Blood parameters were examined on a SYSMEX XT – 2000i hematological analyzer (Japan). Conclusion. Lofant anise extract, obtained by supercritical fluid extraction using CO2, has a bacteriostatic effect on M. leprae, which is not only comparable to the effect of dapsone, but also with a more prolonged course exceeding it. Unlike the drug of choice (dapsone), the extract, when administered for 30 days, does not cause changes in red blood parameters and does not cause neutropenia. The identified effects actualize further research of the extract for the development of dosage forms based on it for practical health care.

Pharmacotherapy of Attention-Deficit Hyperactivity Disorder

1993 ◽  
Vol 38 (6) ◽  
pp. 443-448 ◽  
Author(s):  
Jovan G. Simeon ◽  
Doreen M. Wiggins
Keyword(s):  
Physical Activity ◽  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Impulse Control ◽  
Patient Management ◽  
Term Therapy ◽  
Hyperactivity Disorder ◽  
Drug Of Choice ◽  
Long Term Therapy

Attention-deficit hyperactivity disorder, characterized by poor sustained attention, diminished impulse control and excessive physical activity, is found in most cultures and most countries. However, diagnostic terminology and management vary from centre to centre. Pharmacotherapy in conjunction with individual and family therapy is generally accepted as the most effective treatment, while psychostimulants are the drug of choice. The results of clinical studies with indications, contraindications and side-effects are reviewed. The use of alternative pharmacotherapy for those who do not respond to treatment and long term therapy is discussed. The need for careful diagnosis and patient management is emphasized.

scholarly journals VALSARTAN IN PHARMACOTHERAPY OF CARDIOVASCULAR DISEASES

2013 ◽  
Vol 19 (5) ◽  
pp. 458-471 ◽  
Author(s):  
M. L. Maksimov ◽  
A. S. Ermolaeva ◽  
O. V. Dralova
Keyword(s):  
Angiotensin Receptor Blockers ◽  
Term Therapy ◽  
Primary And Secondary Prevention ◽  
Drug Of Choice ◽  
Receptor Blockers ◽  
Relevant Group ◽  
Long Term Therapy ◽  
New Onset

Angiotensin receptor blockers represent a relevant group of cardiovascular drugs. The results of clinical trials of a generic Valsartan (Valsakor) are reviewed in the paper. Valsartan combines high antihypertensive and organoprotective effects with the low risk of signiicant drug interactions. Due to the favorable metabolic proile valsartan is the drug of choice in hypertension, metabolic syndrome and type 2 diabetes mellitus, and the long-term therapy is associated with the reduction of the risk of new-onset diabetes. Valsartan is effective in primary and secondary prevention of atrial ibrillation, congestive heart failure and chronic renal failure.

Antithrombotic Therapy for DVT/PE

1997 ◽  
Vol 17 (03) ◽  
pp. 161-162
Author(s):  
Thomas Hyers
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Oral Anticoagulants ◽  
Cost Effective ◽  
Therapeutic Agents ◽  
Great Promise ◽  
Term Therapy ◽  
Low Molecular Weight ◽  
Long Term Therapy

SummaryProblems with unfractionated heparin as an antithrombotic have led to the development of new therapeutic agents. Of these, low molecular weight heparin shows great promise and has led to out-patient therapy of DVT/PE in selected patients. Oral anticoagulants remain the choice for long-term therapy. More cost-effective ways to give oral anticoagulants are needed.

Office-based post-marketing surveillance study on the influence of long term therapy with aripiprazole in patients with schizophrenia

2007 ◽  
Vol 40 (05) ◽  
Author(s):  
M Kungel ◽  
A Engelhardt ◽  
T Spevakné-Göröcs ◽  
M Ebrecht ◽  
C Werner ◽  
...  
Keyword(s):  
Surveillance Study ◽  
Term Therapy ◽  
Post Marketing Surveillance ◽  
Post Marketing ◽  
Long Term Therapy

Analytical Supercritical Fluid Extraction

1994 ◽  
Author(s):  
Maria Dolores Luque de Castro ◽  
Miguel Valcárcel ◽  
Maria Teresa Tena
Keyword(s):  
Supercritical Fluid Extraction ◽  
Supercritical Fluid ◽  
Fluid Extraction

VOLATILES IN TAMAIOASA ROMANEASCA VIA SUPERCRITICAL FLUID EXTRACTION (SFE) ANALYSIS

2015 ◽  
Vol 14 (2) ◽  
pp. 297-302 ◽  
Author(s):  
Valeriu V. Cotea ◽  
Lucia Cintia Colibaba ◽  
Liliana Rotaru ◽  
Bogdan Nechita ◽  
Marius Niculaua ◽  
...  
Keyword(s):  
Supercritical Fluid Extraction ◽  
Supercritical Fluid ◽  
Fluid Extraction
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