The Diagnosis and Recommendation Integrated System (DRIS) has been used successfully in agricultural crops and holds promise for use in forest stands. This study used soil tests to develop DRIS norms and evaluate their effectiveness in coastal Douglas-fir (Pseudotsugamenziesii (Mirb.) Franco) forests. DRIS norms for nitrogen, phosphorus, potassium, and calcium were developed using soil test and site index data from 72 soil series that commonly support Douglas-fir in western Washington. The norms were tested using soil test and stand basal area growth response data from 20 thinned and 30 unthinned N fertilizer test sites in coastal Washington and Oregon. Response to urea fertilizer in thinned stands averaged 34% and 43% for 224 and 448 kg N•ha−1, respectively, when N was identified as the most limiting nutrient. When N was not the most limiting nutrient, N response averaged 8% and 10% for 224 and 448 kg N•ha−1, respectively. Results were similar in unthinned stands and thinned stands, although response to fertilizer appeared to be slightly less in unthinned stands when N was the most limiting nutrient. DRIS correctly classified 25 of the 33 sites (76%) where N fertilizer increased growth by more than 15%. More importantly, 13 of the 17 (76%) sites that responded by less than 15% were correctly identified by DRIS. The results clearly indicate that N fertilizer response is dependent on the interactions (balance) between soil nutrients at a given site. Future soil diagnostic work needs to focus on techniques, like DRIS, that provide an assessment of these interactions.