scholarly journals Pandemic Influenza A (H1N1) 2009 and mortality in the United Kingdom: risk factors for death, April 2009 to March 2010

2010 ◽  
Vol 15 (20) ◽  
Author(s):  
R G Pebody ◽  
E McLean ◽  
H Zhao ◽  
P Cleary ◽  
S Bracebridge ◽  
...  
Keyword(s):  
Risk Factors ◽  
United Kingdom ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Binary File ◽  
The United Kingdom ◽  
Influenza A H1n1

Binary file ES_Abstracts_Final_ECDC.txt matches

scholarly journals International flight-related transmission of pandemic influenza A(H1N1)pdm09: an historical cohort study of the first identified cases in the United Kingdom

2013 ◽  
Vol 8 (1) ◽  
pp. 66-73 ◽  
Author(s):  
Nicholas Young ◽  
Richard Pebody ◽  
Gillian Smith ◽  
Babatunde Olowokure ◽  
Giri Shankar ◽  
...  
Keyword(s):  
Cohort Study ◽  
United Kingdom ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Historical Cohort ◽  
The United Kingdom ◽  
Historical Cohort Study ◽  
Influenza A H1n1

scholarly journals Effectiveness of seasonal 2010/11 and pandemic influenza A(H1N1)2009 vaccines in preventing influenza infection in the United Kingdom: mid-season analysis 2010/11

2011 ◽  
Vol 16 (6) ◽  
Author(s):  
R Pebody ◽  
P Hardelid ◽  
D M Fleming ◽  
J McMenamin ◽  
N Andrews ◽  
...  
Keyword(s):  
United Kingdom ◽  
Influenza Vaccine ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Influenza Infection ◽  
Vaccine Effectiveness ◽  
The United Kingdom ◽  
Trivalent Influenza Vaccine ◽  
Monovalent Vaccine ◽  
Influenza A H1n1

This study provides mid-season estimates of the effectiveness of 2010/11 trivalent influenza vaccine and previous vaccination with monovalent influenza A(H1N1)2009 vaccine in preventing confirmed influenza A(H1N1)2009 infection in the United Kingdom in the 2010/11 season. The adjusted vaccine effectiveness was 34% (95% CI: -10 - 60%) if vaccinated only with monovalent vaccine in the 2009/10 season; 46% (95% CI: 7 - 69%) if vaccinated only with trivalent influenza vaccine in the 2010/11 season and 63% (95% CI: 37 - 78%) if vaccinated in both seasons.

scholarly journals Effectiveness of seasonal influenza vaccine for adults and children in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 end-of-season results

2016 ◽  
Vol 21 (38) ◽  
Author(s):  
Richard Pebody ◽  
Fiona Warburton ◽  
Joanna Ellis ◽  
Nick Andrews ◽  
Alison Potts ◽  
...  
Keyword(s):  
Primary Care ◽  
United Kingdom ◽  
Influenza Vaccine ◽  
Influenza A ◽  
Immunisation Programme ◽  
Influenza B ◽  
Live Attenuated Influenza Vaccine ◽  
The United Kingdom ◽  
Influenza A H1n1 ◽  
The Uk

The United Kingdom (UK) is in the third season of introducing universal paediatric influenza vaccination with a quadrivalent live attenuated influenza vaccine (LAIV). The 2015/16 season in the UK was initially dominated by influenza A(H1N1)pdm09 and then influenza of B/Victoria lineage, not contained in that season’s adult trivalent inactivated influenza vaccine (IIV). Overall adjusted end-of-season vaccine effectiveness (VE) was 52.4% (95% confidence interval (CI): 41.0–61.6) against influenza-confirmed primary care consultation, 54.5% (95% CI: 41.6–64.5) against influenza A(H1N1)pdm09 and 54.2% (95% CI: 33.1–68.6) against influenza B. In 2–17 year-olds, adjusted VE for LAIV was 57.6% (95% CI: 25.1 to 76.0) against any influenza, 81.4% (95% CI: 39.6–94.3) against influenza B and 41.5% (95% CI: −8.5 to 68.5) against influenza A(H1N1)pdm09. These estimates demonstrate moderate to good levels of protection, particularly against influenza B in children, but relatively less against influenza A(H1N1)pdm09. Despite lineage mismatch in the trivalent IIV, adults younger than 65 years were still protected against influenza B. These results provide reassurance for the UK to continue its influenza immunisation programme planned for 2016/17.

scholarly journals Mortality of 2009 pandemic influenza A(H1N1) in Germany

2010 ◽  
Vol 15 (49) ◽  
Author(s):  
H Wilking ◽  
S Buda ◽  
E von der Lippe ◽  
D Altmann ◽  
G Krause ◽  
...  
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
Binary File ◽  
Influenza A H1n1

Binary file ES_Abstracts_Final_ECDC.txt matches

scholarly journals Virological analysis of fatal influenza cases in the United Kingdom during the early wave of influenza in winter 2010/11

2011 ◽  
Vol 16 (1) ◽  
Author(s):  
J Ellis ◽  
M Galiano ◽  
R Pebody ◽  
A Lackenby ◽  
CI Thompson ◽  
...  
Keyword(s):  
United Kingdom ◽  
Vaccine Strain ◽  
Influenza A ◽  
Influenza Season ◽  
Severe Illness ◽  
Influenza B ◽  
The United Kingdom ◽  
Influenza A H1n1 ◽  
Influenza Activity ◽  
Children And Young Adults

The 2010/11 winter influenza season is underway in the United Kingdom, with co-circulation of influenza A(H1N1)2009 (antigenically similar to the current 2010/11 vaccine strain), influenza B (mainly B/Victoria/2/87 lineage, similar to the 2010/11 vaccine strain) and a few sporadic influenza A(H3N2) viruses. Clinical influenza activity has been increasing. Severe illness, resulting in hospitalisation and deaths, has occurred in children and young adults and has predominantly been associated with influenza A(H1N1)2009, but also influenza B viruses.

scholarly journals Use of an inactivated vaccine in mitigating pandemic influenza A(H1N1) spread: a modelling study to assess the impact of vaccination timing and prioritisation strategies

2009 ◽  
Vol 14 (41) ◽  
Author(s):  
V Sypsa ◽  
I Pavlopoulou ◽  
A Hatzakis
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
Inactivated Vaccine ◽  
Binary File ◽  
Influenza A H1n1 ◽  
The Impact ◽  
Modelling Study

Binary file ES_Abstracts_Final_ECDC.txt matches

scholarly journals Risk factors for severe outcome of cases with pandemic influenza A(H1N1)pdm09

2015 ◽  
Vol 116 (06) ◽  
pp. 389-393 ◽  
Author(s):  
L. Hlavinkova ◽  
Z. Kristufkova ◽  
J. Mikas
Keyword(s):  
Risk Factors ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Influenza A H1n1

scholarly journals Hospitalized Children with 2009 Pandemic Influenza A (H1N1): Comparison to Seasonal Influenza and Risk Factors for Admission to the ICU

PLoS ONE ◽  
2010 ◽  
Vol 5 (12) ◽  
pp. e15173 ◽  
Author(s):  
Dayanand Bagdure ◽  
Donna J. Curtis ◽  
Emily Dobyns ◽  
Mary P. Glodé ◽  
Samuel R. Dominguez
Keyword(s):  
Risk Factors ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Seasonal Influenza ◽  
Hospitalized Children ◽  
Influenza A H1n1

scholarly journals Hospitalized Adult Patients with 2009 Pandemic Influenza A (H1N1) in Kaunas, Lithuania

Medicina ◽  
2011 ◽  
Vol 47 (1) ◽  
pp. 11-18 ◽  
Author(s):  
◽  
◽  
◽  
◽  
◽  
...  
Keyword(s):  
Risk Factors ◽  
Symptom Onset ◽  
Pandemic Influenza ◽  
Influenza A ◽  
H1n1 Virus ◽  
Clinical Course ◽  
Antiviral Treatment ◽  
Course Of Illness ◽  
Influenza A H1n1 ◽  
Complicated Course

The objective of this study was to identify case characteristics and clinical course of the disease in patients hospitalized with 2009 pandemic influenza A (H1N1) infection during the first wave of the pandemic and to identify risk factors associated with the complicated course of illness. Material and methods. A retrospective study of adult cases of the laboratory-confirmed 2009 pandemic influenza A (H1N1) virus admitted to three hospitals in Kaunas between November 1, 2009, and March 15, 2010, was carried out. The main outcome measures were clinical characteristics, risk factors for complicated disease, treatment, and clinical course of the disease. Results. The study enrolled 121 of the 125 patients hospitalized due to 2009 pandemic influenza A (H1N1) virus infection. The median age was 31 years (range, 18–83); 5% of the patients were aged more than 65 years. Pregnant and postpartum women comprised 26% of all hospitalized cases. Nearly half (49.5%) of those who underwent chest radiography had findings consistent with pneumonia, which was bilateral in one-third of cases. The risk to have pandemic influenza complicated by pneumonia increased significantly with one-day delay from symptom onset to antiviral treatment (OR, 2.241; 95% CI, 1.354–3.710). More than half (57%) of the patients received antiviral treatment. In 45% of the treated patients, antiviral drugs were administered within 48 hours from symptom onset. Intensive care was required in 7.4% of the cases. The overall mortality was 5% (6/121). The median age of the patients who died was 43.5 years (range, 23–62); 4 patients had been previously healthy, 1 patient suffered from chronic lympholeukemia, and 1 patient was a pregnant woman. Conclusion. The 2009 pandemic influenza A (H1N1) caused considerable morbidity in a significant proportion of hospitalized adults. The main risk factor associated with the complicated course of illness was delayed antiviral treatment.

scholarly journals The return of the historic influenza A H1N1 virus and its impact on the population of the United Kingdom

1982 ◽  
Vol 89 (1) ◽  
pp. 89-100 ◽  
Author(s):  
P. Chakraverty ◽  
P. Cunningham ◽  
M. S. Pereira
Keyword(s):  
United Kingdom ◽  
Influenza A ◽  
Antigenic Variation ◽  
Adult Population ◽  
Age Distribution ◽  
Age Groups ◽  
The United Kingdom ◽  
Influenza A H1n1 ◽  
Older Adult Population ◽  
The Impact

SUMMARYThe epidemiology in the United Kingdom of the influenza A H1N1 subtype which returned in 1977 after an absence of 20 years is described for the four winter seasons from 1977/8 to 1980/1. The age distribution of virus isolates and the evidence for antigenic variation is presented. The impact in the susceptible age groups year by year is shown by the change in the population with specific antibody. There was the expected increase of antibody in those under the age of 21 but also evidence for a significant amount of infection or re-infection in the older adult population.

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