International flight-related transmission of pandemic influenza A(H1N1)pdm09: an historical cohort study of the first identified cases in the United Kingdom

This study provides mid-season estimates of the effectiveness of 2010/11 trivalent influenza vaccine and previous vaccination with monovalent influenza A(H1N1)2009 vaccine in preventing confirmed influenza A(H1N1)2009 infection in the United Kingdom in the 2010/11 season. The adjusted vaccine effectiveness was 34% (95% CI: -10 - 60%) if vaccinated only with monovalent vaccine in the 2009/10 season; 46% (95% CI: 7 - 69%) if vaccinated only with trivalent influenza vaccine in the 2010/11 season and 63% (95% CI: 37 - 78%) if vaccinated in both seasons.

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Faculty Opinions recommendation of Extracorporeal membrane oxygenation for pandemic influenza A(H1N1)-induced acute respiratory distress syndrome: a cohort study and propensity-matched analysis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718178091.793486987 ◽

2013 ◽

Author(s):

Graeme MacLaren

Keyword(s):

Acute Respiratory Distress Syndrome ◽

Cohort Study ◽

Extracorporeal Membrane Oxygenation ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Pandemic Influenza ◽

Influenza A ◽

Distress Syndrome ◽

Membrane Oxygenation ◽

Influenza A H1n1

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Effectiveness of seasonal influenza vaccine for adults and children in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 end-of-season results

Eurosurveillance ◽

10.2807/1560-7917.es.2016.21.38.30348 ◽

2016 ◽

Vol 21 (38) ◽

Cited By ~ 56

Author(s):

Richard Pebody ◽

Fiona Warburton ◽

Joanna Ellis ◽

Nick Andrews ◽

Alison Potts ◽

...

Keyword(s):

Primary Care ◽

United Kingdom ◽

Influenza Vaccine ◽

Influenza A ◽

Immunisation Programme ◽

Influenza B ◽

Live Attenuated Influenza Vaccine ◽

The United Kingdom ◽

Influenza A H1n1 ◽

The Uk

The United Kingdom (UK) is in the third season of introducing universal paediatric influenza vaccination with a quadrivalent live attenuated influenza vaccine (LAIV). The 2015/16 season in the UK was initially dominated by influenza A(H1N1)pdm09 and then influenza of B/Victoria lineage, not contained in that season’s adult trivalent inactivated influenza vaccine (IIV). Overall adjusted end-of-season vaccine effectiveness (VE) was 52.4% (95% confidence interval (CI): 41.0–61.6) against influenza-confirmed primary care consultation, 54.5% (95% CI: 41.6–64.5) against influenza A(H1N1)pdm09 and 54.2% (95% CI: 33.1–68.6) against influenza B. In 2–17 year-olds, adjusted VE for LAIV was 57.6% (95% CI: 25.1 to 76.0) against any influenza, 81.4% (95% CI: 39.6–94.3) against influenza B and 41.5% (95% CI: −8.5 to 68.5) against influenza A(H1N1)pdm09. These estimates demonstrate moderate to good levels of protection, particularly against influenza B in children, but relatively less against influenza A(H1N1)pdm09. Despite lineage mismatch in the trivalent IIV, adults younger than 65 years were still protected against influenza B. These results provide reassurance for the UK to continue its influenza immunisation programme planned for 2016/17.

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Virological analysis of fatal influenza cases in the United Kingdom during the early wave of influenza in winter 2010/11

Eurosurveillance ◽

10.2807/ese.16.01.19760-en ◽

2011 ◽

Vol 16 (1) ◽

Author(s):

J Ellis ◽

M Galiano ◽

R Pebody ◽

A Lackenby ◽

CI Thompson ◽

...

Keyword(s):

United Kingdom ◽

Vaccine Strain ◽

Influenza A ◽

Influenza Season ◽

Severe Illness ◽

Influenza B ◽

The United Kingdom ◽

Influenza A H1n1 ◽

Influenza Activity ◽

Children And Young Adults

The 2010/11 winter influenza season is underway in the United Kingdom, with co-circulation of influenza A(H1N1)2009 (antigenically similar to the current 2010/11 vaccine strain), influenza B (mainly B/Victoria/2/87 lineage, similar to the 2010/11 vaccine strain) and a few sporadic influenza A(H3N2) viruses. Clinical influenza activity has been increasing. Severe illness, resulting in hospitalisation and deaths, has occurred in children and young adults and has predominantly been associated with influenza A(H1N1)2009, but also influenza B viruses.

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The return of the historic influenza A H1N1 virus and its impact on the population of the United Kingdom

Journal of Hygiene ◽

10.1017/s0022172400070571 ◽

1982 ◽

Vol 89 (1) ◽

pp. 89-100 ◽

Cited By ~ 6

Author(s):

P. Chakraverty ◽

P. Cunningham ◽

M. S. Pereira

Keyword(s):

United Kingdom ◽

Influenza A ◽

Antigenic Variation ◽

Adult Population ◽

Age Distribution ◽

Age Groups ◽

The United Kingdom ◽

Influenza A H1n1 ◽

Older Adult Population ◽

The Impact

SUMMARYThe epidemiology in the United Kingdom of the influenza A H1N1 subtype which returned in 1977 after an absence of 20 years is described for the four winter seasons from 1977/8 to 1980/1. The age distribution of virus isolates and the evidence for antigenic variation is presented. The impact in the susceptible age groups year by year is shown by the change in the population with specific antibody. There was the expected increase of antibody in those under the age of 21 but also evidence for a significant amount of infection or re-infection in the older adult population.

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