scholarly journals Outbreak of legionnaires’ disease in Amsterdam, June-July 2006

2006 ◽  
Vol 11 (28) ◽  
Author(s):  
Collective Editorial team ◽  
A van den Hoek
Keyword(s):  
Antigen Test ◽  
Urinary Antigen ◽  
Urinary Antigen Test ◽  
Legionnaires Disease ◽  
June July

An outbreak of legionnaires’ disease is occurring in Amsterdam, where 23 cases confirmed by urinary antigen test were reported between 6 and 13 July 2006, and one patient has died

scholarly journals Unusual clinical picture in an overweight patient with Legionella pneumophila: A case report

2017 ◽  
Vol 4 (3) ◽  
pp. 31
Author(s):  
Leonidas Grigorakos ◽  
Daria Lazarescu ◽  
Anthi Georgiadou ◽  
Maria Bikou ◽  
Magda Gkouni ◽  
...  
Keyword(s):  
Case Report ◽  
Legionella Pneumophila ◽  
Clinical Picture ◽  
Clinical Condition ◽  
Antigen Test ◽  
Overweight Patient ◽  
Urinary Antigen ◽  
Urinary Antigen Test ◽  
Legionnaires Disease ◽  
Continue Therapy

This case report describes a case of a patient with Legionnaires’ disease (LD) manifested three days upon his return from a medical conference, which took place in a hotel close to the seaside. Our patient presented to the hospital febrile, weak, confused and with mild difficulty in breathing. After being subjected to several tests, he was diagnosed with LD. Even though his initial urinary antigen test (UAT) was negative, subsequent immunofluorescent assays (IFA) were positive for Legionella pneumophila (LP). The patient was immediately initiated specific antibiotics therapy and supportive measures. After 11 days he was released from the hospital with considerable melioration of his clinical condition and with specific instructions to continue therapy at home.

scholarly journals Travel associated legionnaires' disease in Europe: 2002

2004 ◽  
Vol 9 (2) ◽  
pp. 6-9 ◽  
Author(s):  
K D Ricketts ◽  
C Joseph ◽  
Keyword(s):  
Peak Activity ◽  
Antigen Test ◽  
Travel Patterns ◽  
Urinary Antigen ◽  
Urinary Antigen Test ◽  
Legionnaires Disease ◽  
Surveillance Scheme

Twenty countries reported 676 cases of travel associated legionnaires' disease to the EWGLINET surveillance scheme, and 94 clusters were detected. 80.5% of all cases were diagnosed by the urinary antigen test. On average there were 20.5 days between onset and report of cases, compared with 51.5 days in 1993. Between the introduction of the EWGLI investigation guidelines (on 1st July 2002) and the end of 2002, 37 six-week investigation reports were accepted as satisfactory and on time by the coordinating centre. 274 sites were investigated in total in 2002. The travel patterns of the main reporters in EWGLINET influenced the months of peak activity, and helped to determine which countries bore the greatest investigation burden.

scholarly journals Travel-associated legionnaires’ disease in Europe: 2004

2006 ◽  
Vol 11 (4) ◽  
pp. 13-14 ◽  
Author(s):  
K D Ricketts ◽  
B McNaught ◽  
C A Joseph
Keyword(s):  
Case Fatality Rate ◽  
Case Fatality ◽  
Control Measures ◽  
Antigen Test ◽  
Urinary Antigen ◽  
Urinary Antigen Test ◽  
Legionnaires Disease ◽  
And Control ◽  
Surveillance Scheme ◽  
Made In

Six hundred and fifty five cases of travel-associated legionnaires’ disease with onset in 2004 have been reported to the EWGLINET surveillance scheme by 25 countries. A total of 84.9% of cases were diagnosed by the urinary antigen test, and 37 cultures were obtained. Thirty seven deaths were reported, giving a case fatality rate of 5.6%. Eighty six new clusters were detected, 45% of which would not have been detected without the EWGLINET scheme. Ninety four accommodation sites were investigated and the names of four sites were published on the EWGLI website. Fifteen sites were associated with additional cases after a report was received to say that investigations and control measures had been satisfactorily carried out. Further improvements could be made in the data collected on deaths due to travel-associated legionnaires’ disease, and on the number of samples taken for culture throughout Europe.

Clinical utility of urinary antigen test and molecular method for detection of Legionella pneumophila.

2018 ◽  
Vol 9 (SPL1) ◽  
Author(s):  
Thana’a R AbdulRahman
Keyword(s):  
Legionella Pneumophila ◽  
Point Of View ◽  
P Value ◽  
Antigen Test ◽  
Rt Pcr ◽  
Urinary Antigen ◽  
Urinary Antigen Test ◽  
Serum Samples ◽  
High Prevalence ◽  
Legionnaires Disease

Legionella pneumophila is gram-negative bacterium which causes Legionnaires’ disease and Pontiac fever.To determine the frequency of serogroup 1 and other serogroup of Legionellapneumophila in pneumonic patients and the clinical utilityofLegionellapneumoniaurinary antigen test (LPUAT)in terms of sensitivity and specificity andcomparethe results with q Real Time PCR using serum samples. A total of 100 pneumonic patients were enrolled in this studyduring a period between October 2016 to April 2017; all patients under therapy with antibiotics.Serum and urine specimens were obtained from all patients; urine samples were processed for urinary antigen test. Serum samples were collected and submitted to DNA extraction for detection of L. pneumophila mip gene by q RT PCRassay. The percentage of L. pneumophila in two hospitals In Baghdad was 30%. Of these 26% was serogroup 1 detected by UAT. In the other hand, 23 % of samples were positive by q RT- PCR based mip gene,of these 19 % were serogroup 1 and 4% were other serogroups. The sensitivity of UAT is high (P value< 0.001), which means statistically highlysignificance than q RT PCR. Legionellapneumophila urinary antigen test is a rapid tool for early diagnosis of Legionella infection which highlights the need of using this test in hospitals and health institutions and there is a high prevalence of L.pneumophila in Iraqthat refer to the necessity of considering this microorganism point of view in future studies for detection and treatment in pneumonic patients.

scholarly journals The impact of diagnosis by legionella urinary antigen test on the epidemiology and outcomes of Legionnaires' disease

2001 ◽  
Vol 127 (2) ◽  
pp. 275-280 ◽  
Author(s):  
N. FORMICA ◽  
M. YATES ◽  
M. BEERS ◽  
J. CARNIE ◽  
G. HOGG ◽  
...  
Keyword(s):  
Legionella Pneumophila ◽  
Community Acquired Pneumonia ◽  
Antigen Test ◽  
Urinary Antigen ◽  
Urinary Antigen Test ◽  
Disease Epidemiology ◽  
The Public ◽  
Life Threatening ◽  
Legionnaires Disease ◽  
The Impact

Legionnaires' disease is an uncommon but important cause of life-threatening community-acquired or nosocomial pneumonia. The urinary antigen enzyme immunoassay test, used in Victoria since 1995, now accounts for the majority of initial laboratory notifications (81% in 1999). We review the impact of the test on the disease epidemiology and the public health investigative process. We focus on the major subgroup of cases due to Legionella pneumophila serogroup 1, comparing delays until notification and mortality for urinary antigen detected cases with culture detected cases. The urinary antigen test facilitates a 5-day reduction for the delay between onset of illness and notification. We observed that there was minimal clinical heterogeneity of urinary antigen detected cases whether they were subsequently culture confirmed or not. We encourage clinician use of the urinary antigen test in cases of community-acquired pneumonia where Legionnaires' disease is a possible diagnosis, in conjunction with culture of clinical specimens.

scholarly journals Travel-associated legionnaires’ disease in Europe: 2005

2007 ◽  
Vol 12 (1) ◽  
pp. 15-16 ◽  
Author(s):  
K D Ricketts ◽  
B McNaught ◽  
C A Joseph ◽  
Collective European Working Group for Legionella Infections
Keyword(s):  
Case Fatality Rate ◽  
Case Fatality ◽  
Fatality Rate ◽  
Antigen Test ◽  
Urinary Antigen ◽  
Urinary Antigen Test ◽  
Legionnaires Disease ◽  
Surveillance Scheme

In 2005, 755 cases of travel-associated legionnaires’ disease with onset in 2005 were reported to the EWGLINET surveillance scheme by 20 countries. A total of 85.8% of cases were diagnosed by the urinary antigen test, and 37 cultures were obtained. Twenty nine deaths were reported, giving a case fatality rate of 3.8% (down from 5.6% in 2004). Ninety three new clusters were identified, 36.6% of which would not have been detected without the EWGLINET scheme. One hundred and twenty two accommodation sites were investigated and the names of nine sites were published on the EWGLI website.

scholarly journals Travel Associated Legionnaires' Disease in Europe : 2003

2004 ◽  
Vol 9 (10) ◽  
pp. 5-6 ◽  
Author(s):  
K D Ricketts ◽  
C Joseph ◽  
Keyword(s):  
Fatality Rate ◽  
Antigen Test ◽  
Urinary Antigen ◽  
Urinary Antigen Test ◽  
Legionnaires Disease ◽  
Surveillance Scheme

Six hundred and thirty two cases of travel-associated legionnaires' disease with onset in 2003 were reported to the EWGLINET surveillance scheme by 24 countries. Eighty nine clusters were detected, 35 (39%) of which would not have been detected without the EWGLINET scheme. One hundred and seven accommodation sites were investigated and 22 sites were published on the EWGLI website. The proportion of cases diagnosed primarily by the urinary antigen test was 81.2%, and 48 positive cultures were obtained. Thirty eight deaths were reported to the EWGLINET scheme, giving a crude fatality rate of 6%. Countries are encouraged to inform the coordinating centre of cases that fall ill after travelling within their own country of residence ('internal travel'), and are also encouraged to obtain patient isolates for culture where at all possible.

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