scholarly journals Contact tracing of passengers exposed to an extensively drug-resistant tuberculosis case during an air flight from Beirut to Paris, October 2006

2007 ◽  
Vol 12 (49) ◽  
Author(s):  
J Chemardin ◽  
M C Paty ◽  
S Renard-Dubois ◽  
N Veziris ◽  
D Antoine
Keyword(s):  
Contact Tracing ◽  
Drug Resistant ◽  
Tuberculosis Case ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis ◽  
Extensively Drug Resistant

Contact tracing of air travellers exposed to cases of multi-drug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) has become an increasingly important issue.

scholarly journals Contact investigation after a fatal case of extensively drug-resistant tuberculosis (XDR-TB) in an aircraft, Germany, July 2013

2017 ◽  
Vol 22 (12) ◽  
Author(s):  
Maria an der Heiden ◽  
Barbara Hauer ◽  
Lena Fiebig ◽  
Gisela Glaser-Paschke ◽  
Markus Stemmler ◽  
...  
Keyword(s):  
Fatal Case ◽  
Latent Tuberculosis ◽  
Contact Tracing ◽  
Drug Resistant ◽  
Questionnaire Response ◽  
Drug Resistant Tuberculosis ◽  
European Guidelines ◽  
Resistant Tuberculosis ◽  
Extensively Drug Resistant ◽  
Contact Investigation

In July 2013, a passenger died of infectious extensively drug-resistant tuberculosis (XDR-TB) on board of an aircraft after a 3-hour flight from Turkey to Germany. Initial information indicated the patient had moved about the aircraft coughing blood. We thus aimed to contact and inform all persons exposed within the aircraft and to test them for newly acquired TB infection. Two-stage testing within 8 weeks from exposure and at least 8 weeks after exposure was suggested, using either interferon gamma release assays (IGRAs) or tuberculin skin test (TST). The TST cut-off was defined at a diameter > 10 mm; for differentiation between conversion and boosting, conversion was defined as increase of skin induration > 5 mm. Overall, 155 passengers and seven crew members were included in the investigation: the questionnaire response rate was 83%; 112 (69%) persons were tested at least once for TB infection. In one passenger, who sat next to the area where the patient died, a test conversion was registered. As of March 2017, no secondary active TB cases have been reported. We describe an unusual situation in which we applied contact tracing beyond existing European guidelines; we found one latent tuberculosis infection in a passenger, which we consider probably newly acquired.

scholarly journals Molecular surveillance of multi- and extensively drug-resistant tuberculosis transmission in the European Union from 2003 to 2011

2014 ◽  
Vol 19 (11) ◽  
Author(s):  
J L De Beer ◽  
C Ködmön ◽  
M J van der Werf ◽  
J van Ingen ◽  
D van Soolingen ◽  
...  
Keyword(s):  
European Union ◽  
Contact Tracing ◽  
Beijing Genotype ◽  
Drug Resistant ◽  
The European Union ◽  
Molecular Surveillance ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis ◽  
Extensively Drug Resistant ◽  
The Eu

The European Centre for Disease Prevention and Control (ECDC) initiated a project on the molecular surveillance of multi- and extensively drug-resistant tuberculosis (MDR-/XDR-TB) transmission in the European Union (EU) in the period from 2009 to 2011. In total, 2,092 variable number of tandem repeat (VNTR) patterns of MDR-/XDR-TB Mycobacterium tuberculosis isolates were collected, originating from 24 different countries in the period 2003 to 2011. Of the collected VNTR patterns, 45% (n=941) could be assigned to one of the 79 European multiple-country molecular fingerprint clusters and 50% of those (n=470) belonged to one extremely large cluster caused by Beijing strains of one genotype. We conclude that international transmission of MDR-/XDR-TB plays an important role in the EU, especially in the eastern part, and is significantly related to the spread of one strain or clone of the Beijing genotype. Implementation of international cluster investigation in EU countries should reveal underlying factors of transmission, and show how TB control can be improved regarding case finding, contact tracing, infection control and treatment in order to prevent further spread of MDR-/XDR-TB in the EU.

scholarly journals Second-line anti-tuberculosis drug resistance testing in Ghana identifies the first extensively drug-resistant tuberculosis case

2018 ◽  
Vol Volume 11 ◽  
pp. 239-246 ◽  
Author(s):  
Stephen Osei-Wusu ◽  
Michael Amo Omari ◽  
Adwoa Asante-Poku ◽  
Isaac Darko Otchere ◽  
Prince Asare ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Resistance Testing ◽  
Drug Resistant ◽  
Second Line ◽  
Tuberculosis Case ◽  
Drug Resistant Tuberculosis ◽  
Drug Resistance Testing ◽  
Resistant Tuberculosis ◽  
Extensively Drug Resistant
Sign in / Sign up

Export Citation Format

Share Document