Sistem Prediksi Kondisi Kesehatan Pasien Penderita Talasemia dengan Menggunakan Logika Fuzzy Tsukamoto

2021 ◽  
Vol 7 (3) ◽  
Author(s):  
Cintya Fransisca Wijaya ◽  
Lena Magdalena ◽  
Reza Ilyasa
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Hereditary Disease ◽  
Health Condition ◽  
Patient Data ◽  
Health Conditions ◽  
Blood Transfusions ◽  
Prediction System ◽  
Data Scheduling ◽  
Patient Health

Thalassemia is a hereditary disease that makes sufferers experience red blood cell abnormalities and must receive continuous blood transfusions throughout their lives. Gunung Jati Hospital, Cirebon City handles registration and scheduling of thalassemia patients with assistance from Perhimpunan Orang tua Penderita Talasemia Indonesia (POPTI). In handling patient data, it is necessary to have a system that facilitates all activities ranging from registration, scheduling, and make predictions about the patient's health condition along with recommendations for handling the patient's condition. The purpose of this study is to make a prediction system for health conditions related to thalassemia suffered by patients based on influencing variables using the Fuzzy Tsukamoto method. This system can also handle patient data, scheduling, and storing patient medical recap data. The final results of this system are patient data, patient care schedules, predictions of patient health conditions, and recommendations for patients.   Keywords— Fuzzy; Prediction; thalassemia; Tsukamoto.

scholarly journals Evolution of Practices in a French Trauma Centre: Decrease in Blood Transfusions and Fresh Frozen Plasma to Red Blood Cell Ratios

2021 ◽  
Vol 49 (5) ◽  
pp. 365-372
Author(s):  
Cyril Pernod ◽  
◽  
Laurie Fraticelli ◽  
Guillaume Marcotte ◽  
Bernard Floccard ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Fresh Frozen Plasma ◽  
Trauma Centre ◽  
Blood Transfusions ◽  
Fresh Frozen ◽  
Frozen Plasma

Paediatric palliative care: why transfuse?

2021 ◽  
pp. bmjspcare-2020-002582
Author(s):  
Guillaume Robert ◽  
Celine Chappe ◽  
Ana Ferreira ◽  
Elisabeth MC Ewan ◽  
Sara Calmanti
Keyword(s):  
Public Health ◽  
Palliative Care ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Blood Test ◽  
Stage Iv ◽  
Blood Transfusions ◽  
Transfusion Strategy ◽  
Paediatric Palliative Care ◽  
Stage Iv Neuroblastoma

Should indication for transfusion in paediatric palliative care be based on the child’s perspective rather than the biological results? An 8-year-old boy presenting a relapse of a stage IV neuroblastoma received regular blood transfusions. A severe exophtalmia led the doctors to question the transfusion strategy. Over 7.5 months, the child received 56 red blood cell units and 31 platelet units. He was hospitalised 50 times. Indication for blood test and transfusion may be regularly and collegially reassessed. Transfusion needs in a palliative strategy can be as high as in a curative strategy. Practices, benefits but also ethical and public health dimensions should be more studied.

Therapeutic Red Blood Cell Exchange in Sickle Cell Anaemia Using the Spectra Optia® Apheresis System

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 4383-4383
Author(s):  
Sabine Sipurzynski-Budraâ ◽  
Petra Sovinz ◽  
Gerhard Lanzer ◽  
Katharina Schallmoser
Keyword(s):  
Side Effects ◽  
Blood Cell ◽  
Iron Overload ◽  
Sickle Cell ◽  
Red Blood Cell ◽  
Organ Damage ◽  
Blood Transfusions ◽  
Adverse Side Effects ◽  
Sickle Cells

Abstract Abstract 4383 Background: Sickle cell disease, an autosomal recessive genetic blood disorder, is caused by abnormal hemoglobin (Hb) due to a substitution of valine by glutamic acid at β6 (HbS). Typical adverse events are vaso-occlusive crises due to obstruction of capillaries causing ischemia, pain and organ damage, as well as enhanced hemolysis and frequent hemolytic crises. Further complications may include acute chest syndrome and stroke. To prevent long-term sequelae, repeated blood transfusions are necessary to decrease erythropoiesis of sickle cells. We suggest that it may be more effective to reduce sickle cells by a red blood cell (RBC) exchange, which is advantageous in avoiding iron overload by transfusions. Patient and Methods: We report on a 10 year old boy suffering from the homozygote form of sickle cell anemia. RBC exchange was performed using the Spectra Optia® Apheresis System (Caridian BCT vers.5) when the patient's hematocrit (hct) was less than 26%. Traditional RBC exchange was modified by a depletion phase to improve efficacy. During this phase (= isovolemic hemodilution) HbS-containing red cells were removed without admixture of donor red cells by using plasma as replacement fluid. To prevent adverse side effects caused by adenine, the additive solution in the RBC concentrates was replaced by saline solution or plasma. Results: The therapeutic apheresis was feasible repeatedly via peripheral venous access (flow: 30 ± 3 mL/min, anticoagulant (AC) infusion rate 0.8 – 1.1mL/min/L total blood volume, inlet: AC ratio 13: 1) and no adverse side effects were observed. The median interval between the procedures was 42 ± 2 days. The depletion time (replacement fluid: plasma) was 25 ± 5 min, the exchange time 90 ± 10 min. The hct value at the end of the procedure was between 33 and 34%, the fraction of the patient's remaining cells (FCR) was 24 ± 2% (calculated by the device). Conclusion: RBC exchange with the Optia Spectra® System is a fast and safe method for reducing sickle cells, particularly efficient in combination with a depletion phase. Compared to blood transfusions alone, the HbS concentration declines rapidly by depleting and replacing sickle cells with normal RBCs without hyperviscosity or iron overload. However, only long-term surveillance and treatment of a larger patient collective will show whether it is possible to prevent vaso-occlusive crises and organ damage over a longer time period. Disclosures: No relevant conflicts of interest to declare.

Packed Red Blood Cell Transfusions in Critically Ill Patients

2011 ◽  
Vol 31 (1) ◽  
pp. 25-34 ◽  
Author(s):  
Tara Ann Collins
Keyword(s):  
Blood Cell ◽  
Critically Ill ◽  
Red Blood Cell ◽  
Critically Ill Patients ◽  
Critical Review ◽  
Red Blood Cell Transfusion ◽  
Blood Transfusions ◽  
Change In Practice ◽  
Red Blood Cell Transfusions ◽  
Stored Blood

Anemia, which is prevalent in critically ill patients, often requires frequent blood transfusions. These blood transfusions are not without risks. A critical review of 6 studies shows an association between red blood cell transfusion and increased mortality. However, when disease state was adjusted for in 2 studies, researchers found that red blood cell transfusion correlated with decreased mortality. Thus further research, particularly on leukoreduction and age of stored blood, must be done before a change in practice can be implemented. It is vital that nurses stay current on this research in order to improve patients’ outcomes.

scholarly journals Study of Frequency and Characteristics of Red Blood Cell Alloimmunization in Thalassemic Patients: Multicenter Study from Palestine

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Adham Abu Taha ◽  
Ahmad Yaseen ◽  
Sa’d Suleiman ◽  
Omar Abu Zenah ◽  
Hammam Ali ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Blood Transfusions ◽  
Antibody Screening ◽  
Multicenter Observational Study ◽  
Screening And Identification ◽  
History Of ◽  
Gel Technique ◽  
Prospective Multicenter Observational Study ◽  
Rbc Transfusion

Background. β-Thalassemia is a common inherited hemolytic disorder in Palestine. Red blood cell (RBC) transfusion is the principal treatment but it may cause RBC alloimmunization. This study was conducted to determine the prevalence and characteristics of RBC alloimmunization among thalassemic patients in northern governorates of Palestine. Methods. A prospective multicenter observational study was conducted in the thalassemia transfusion centers in the northern governorates of Palestine. The study included 215 thalassemia patients who received regular blood transfusions. Clinical and transfusion records of patients were examined. Antibody screening and identification was conducted using the microcolum gel technique. Results. Two hundred fifteen patients were included in the study. More than half (52.1%) of the patients were males. The median age of patients was 18 years (range: 12–24 years). The most frequent blood group was A (40.5%). Alloantibodies were detected in 12.6% of patients. Anti-D (33.3%), anti-K (25.9%) and anti-E (14.8%) were the most commonly isolated antibodies. There was no association between age, sex, starting age of transfusion, number of transfused units, history of splenectomy and alloimmunization. Conclusions. Anti-Rh and anti-K antibodies were common among this cohort of patients. Age, sex, starting age of transfusion, number of transfused units, and history of splenectomy could not predict the occurrence of alloimmunization.

Meta-analysis of plasma to red blood cell ratios and mortality in massive blood transfusions for trauma

Injury ◽  
2013 ◽  
Vol 44 (12) ◽  
pp. 1693-1699 ◽  
Author(s):  
Aneel Bhangu ◽  
Dmitri Nepogodiev ◽  
Heidi Doughty ◽  
Douglas M. Bowley
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Meta Analysis ◽  
Blood Transfusions

scholarly journals Intelligent Healthcare Platform Solution and Medication Management System for Elderly People with Long Term Health Conditions

2021 ◽  
Author(s):  
Riyad Elsaadi ◽  
Mahmoud Shafik
Keyword(s):  
Learning Algorithm ◽  
Medication Management ◽  
Healthcare Providers ◽  
The Elderly ◽  
Health Condition ◽  
Health Conditions ◽  
Health Technologies ◽  
Health History ◽  
Patient Health

Healthcare and NHS faces many challenges in monitoring health conditions specially for patients with long term health conditions and the elderly. The forward view for healthcare providers and the NHS is moving from the hospital routine medical checks towards home environment care with the use of smart IoT and AI. Medication errors and missed medication across the globe, is the main source of harm to the public health. Technologies, specifically wireless health technologies are potential solutions for medication error and medication nonadherence in tracking patients’ medication. This paper presented a solution by developing a real-time wireless sensor network to monitor and check patient’s health condition using devices that transmits data from homes wirelessly to the relevant (caregiver, GP, Hospitals and specialist doctors). The proposed system benefits form the use of algorithms, which is used to provide the quality and quick health care advice to the patients at home. The algorithm processes the data from the database webserver. The database stores the patient health history conditions with all measurement obtained from the devices, such as blood pressure, blood glucose, heart rate and body temperature. This data is processed in machine learning algorithm to generate notifications for any changes occur in user’s health and by checking their history records. ML can detect patterns within patient healthcare records and inform clinicians of any anomalies.

scholarly journals Analysis of Cell Saver use and mortality in liver transplant

2017 ◽  
Vol 20 (3) ◽  
pp. 11-13
Author(s):  
André Ibrahim David ◽  
Catiana Mitica Gritti ◽  
André Gustavo Santos Pereira ◽  
Tiago Emanuel de Souza ◽  
Felipe Sbrolini Borges ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Similar Amount ◽  
Blood Transfusions ◽  
Cell Saver ◽  
Cell Recovery ◽  
Liver Transplants ◽  
Perioperative Mortality ◽  
Transplant Patients ◽  
Multiple Blood

Introduction: Liver transplantation is considered the best treatment for irreversible liver disease. Due to the complexity of the procedure generally multiple blood transfusions are required. One option to reduce this need is the use of Cell Saver providing blood cell recovery and reinfusion. Purpose: to evaluate mortality in the number of washed red blood cell units recovered by Cell Saver and perioperative mortality. Methods: Data collection of transplant patients using CellSaver on the period from July 2014 to February 2017. Results: Performed 56 liver transplants, the diagnosis prevalent was liver cirrhosis by hepatitis C virus (37,5%). Of these 45 (80,4%) of the transplants used Cell Saver, which had a median MELD of 24,5 (range 7-50). Taking into account the use of Cell Saver in washed red blood cell units and recovered notes a median of four (range 1-45). 12 died (26,7%), the average of these MELD was 25,5 (range 1-50) and the use of washed red blood cell and recovered was a median of 4,5. Conclusion: Patients who died used a similar amount of washed and recovered erythrocyte units.

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