Congenital Heart Disease and Maternal Diabetes Mellitus

2018 ◽  
Vol 1 (3) ◽  
pp. 32-39
Author(s):  
Andreas Petropoulos ◽  
A Khudiyeva ◽  
İ İsmailova
Keyword(s):  
Diabetes Mellitus ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Malformations ◽  
Congenital Heart ◽  
Early Stage ◽  
Maternal Diabetes ◽  
Healthy Population ◽  
Maternal Diabetes Mellitus ◽  
Diabetic Mothers

Diabetes mellitus is a relatively common illness that can complicate pregnancy and result in an increased incidence of congenital malformations. Offspring of diabetic mothers suffering from type IDDM have a fivefold incidence of congenital malformations compared to pregnancies in the general healthy population. Specifically, the pattern of congenital heart disease (CHD) encountered among this group, with an emphasis on abnormalities of laterality, looping and conotruncal septation, suggesting that the maternal metabolic state affects cardiogenesis at a very early stage of the developmental period, prior to 7 weeks of gestation. Although many have been written on the effect of diabetes in pregnant women, less is known for the effects of type II DM and gestational diabetes mellitus (GDM) and its role in provoking CHD. Aim of this paper is to review the literature regarding the types of CHD seen in offspring of mothers suffering from different types of diabetes mellitus, maternal types 1 and 2 and gestational and to comment on the incidences and any differences found in the types of detected CHD.

Congenital Heart Disease and Maternal Diabetes Mellitus

2018 ◽  
Vol 1 (4) ◽  
pp. 32-39
Author(s):  
Nabil Z Seyidov ◽  
Andreas Petropoulos ◽  
A Khudiyeva ◽  
İ İsmailova
Keyword(s):  
Diabetes Mellitus ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Malformations ◽  
Congenital Heart ◽  
Early Stage ◽  
Maternal Diabetes ◽  
Healthy Population ◽  
Maternal Diabetes Mellitus ◽  
Diabetic Mothers

Diabetes mellitus is a relatively common illness that can complicate pregnancy and result in an increased incidence of congenital malformations. Offspring of diabetic mothers suffering from type IDDM have a fivefold incidence of congenital malformations compared to pregnancies in the general healthy population. Specifically, the pattern of congenital heart disease (CHD) encountered among this group, with an emphasis on abnormalities of laterality, looping and conotruncal septation, suggesting that the maternal metabolic state affects cardiogenesis at a very early stage of the developmental period, prior to 7 weeks of gestation. Although many have been written on the effect of diabetes in pregnant women, less is known for the effects of type II DM and gestational diabetes mellitus (GDM) and its role in provoking CHD. Aim of this paper is to review the literature regarding the types of CHD seen in offspring of mothers suffering from different types of diabetes mellitus, maternal types 1 and 2 and gestational and to comment on the incidences and any differences found in the types of detected CHD.

scholarly journals Echocardiographic Study of Congenital Heart Disease in Infants of Diabetic Mother

2019 ◽  
Vol 8 (1) ◽  
pp. 43-47
Author(s):  
Babita Khanal ◽  
Manoj Kumar Shrivastava ◽  
Prakash Kafle ◽  
Pushpa Kumari Shah
Keyword(s):  
Diabetes Mellitus ◽  
Congenital Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Congenital Heart ◽  
College Teaching ◽  
Maternal Diabetes ◽  
Diabetic Mother ◽  
Medical College ◽  
Maternal Diabetes Mellitus

Background: Maternal diabetes mellitus (DM) has been shown to be high risk factor for congenital anomalies. It carries 3-5 times higher risk of incidence compared to the general population. The aims of present study is to investigate and portray the incidence of congenital heart disease in infants of diabetic mothers and know the utility of echocardiography in the early diagnosis of CHD at Nobel Medical College teaching hospital, a tertiary care centre in the eastern part of Nepal and review the current literature. Material & Methods: This is a prospective observational study conducted in Nobel Medical College Teaching hospital, Kanchanbari, Biratnagar Nepal over the period of 12 months. A structured questionnaire was designed which included demographic profile and the Echocardiography findings. The collected data were analysed using window’s SPSS version 20. Results: In the present study of the total deliveries 1.99 % was diabetic mother comprising 208 deliveries.127 had undergone echocardiography in which 10.2 % (n=13) had anomalies. One hundred sixteen were term and 11 were preterm. PDA was the most common anomaly (38.4%) followed by VSD (23.1%) and HCM (15.4%). Conclusion: With the review of current literature it has been found that maternal diabetes mellitus is a significant risk factor for congenital heart disease so it is suggested that the presence of diabetes mellitus in a pregnancy should be taken as a strong suspicious of having CHD and infants should be screened for the same .so as to diagnose the anomaly at the earliest possible.

Congenital Heart Disease in Pregnancies Complicated by Maternal Diabetes Mellitus

Herz ◽  
2010 ◽  
Vol 35 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Lukas A. Lisowski ◽  
Paul M. Verheijen ◽  
Joshua A. Copel ◽  
Charles S. Kleinman ◽  
Sander Wassink ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Maternal Diabetes ◽  
Maternal Diabetes Mellitus

scholarly journals A study of clinical, metabolic and hematological profile in infants of diabetic mothers

2014 ◽  
Vol 2 (02) ◽  
pp. 34-40 ◽  
Author(s):  
Girish Gopal
Keyword(s):  
Diabetes Mellitus ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Birth Weight ◽  
Gestational Age ◽  
Congenital Anomalies ◽  
Congenital Heart ◽  
Neonatal Period ◽  
Infants Of Diabetic Mothers ◽  
Diabetic Mothers

Background:Diabetes has long been associated with maternal and perinatal mobidity and mortality. Infants of diabetic mothers (IDMs) have higher risks for serious problems during pregnancy, delivery and early neonatal period. Abnormal fetal metabolism during pregnancy which is complicated by maternal diabetes mellitus results in multiple neonatal sequelae. Objective: To study the clinical, metabolic and hematological profile in infants of diabetic mothers and to compare the neonatal outcome in gestational and pregestational (overt) diabetic mothers. Methods: 69 neonates born to diabetic mothers were enrolled in the study. Gestational age, birth weight, relevant perinatal history and examination findings were recorded. Blood samples were collected to perform relevant biochemical tests and managed as per unit protocol. Echocardiography and ultrasound abdomen was done routinely in all neonates. Results: Of the 69 neonates, 71.01% (49/69) were born to mothers with gestational diabetes mellitus (GDM), while the remaining 28.99% (20/69) were born to mothers with pregestational (overt) diabetes mellitus (PGDM). 53.63% (37/69) of mothers had poor glycemic control. Most of the neonates (73.91% - 51/69) were delivered by cesarean section. 88.40% (61/69) of the babies were born at term. Majority of them (85.50% - 59/69) were appropriate for gestational age with mean birth weight of 3.06±0.82kgs. Hypoglycemia was the most common metabolic abnormality seen in 73.91% (51/69) of neonates. Polycythemia was seen in 60.80% (42/69) of neonates. Congenital malformations were seen in 17.40% (12/69) of neonates, of which most of them had congenital heart disease. 11.60% (8/69) of the babies had suffered birth injuries. 5.80% (4/69) of neonates died in the early neonatal period. Occurrence of hypoglycemia, polycythemia, hyperbilirubinemia, congenital anomalies and birth injuries were significantly higher in infants born to mothers with GDM, whereas hypocalcemia and hypomagnesemia were significantly higher in infants of mothers with PGDM. Conclusions: Among the pregnancies complicated by diabetes, GDM continues to have a major contribution. Hypoglycemia and polycythemia remain the most common biochemical and hematological abnormality respectively. Congenital heart disease forms a major proportion of the congenital anomalies seen in IDMs. Mortality rate is higher in infants born to mothers with GDM.

scholarly journals Personalized Genetic Diagnosis of Congenital Heart Defects in Newborns

2021 ◽  
Vol 11 (6) ◽  
pp. 562
Author(s):  
Olga María Diz ◽  
Rocio Toro ◽  
Sergi Cesar ◽  
Olga Gomez ◽  
Georgia Sarquella-Brugada ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart Defects ◽  
Congenital Malformations ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Heart Defects ◽  
Genetic Diagnosis ◽  
Single Nucleotide Variants ◽  
Personalized Approach

Congenital heart disease is a group of pathologies characterized by structural malformations of the heart or great vessels. These alterations occur during the embryonic period and are the most frequently observed severe congenital malformations, the main cause of neonatal mortality due to malformation, and the second most frequent congenital malformations overall after malformations of the central nervous system. The severity of different types of congenital heart disease varies depending on the combination of associated anatomical defects. The causes of these malformations are usually considered multifactorial, but genetic variants play a key role. Currently, use of high-throughput genetic technologies allows identification of pathogenic aneuploidies, deletions/duplications of large segments, as well as rare single nucleotide variants. The high incidence of congenital heart disease as well as the associated complications makes it necessary to establish a diagnosis as early as possible to adopt the most appropriate measures in a personalized approach. In this review, we provide an exhaustive update of the genetic bases of the most frequent congenital heart diseases as well as other syndromes associated with congenital heart defects, and how genetic data can be translated to clinical practice in a personalized approach.

CONGENITAL HEART DISEASE

PEDIATRICS ◽  
1950 ◽  
Vol 6 (2) ◽  
pp. 299-304
Author(s):  
STANLEY GIBSON
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Private Practice ◽  
Congenital Malformations ◽  
Congenital Heart ◽  
Pediatric Practice ◽  
Medical Centers ◽  
Additional Burden ◽  
Cardiac Diagnosis ◽  
Cardiovascular Anomalies

A short while ago, I asked a busy pediatrician of long experience how many "blue babies" he had seen in the course of his practice. He thought for a moment, then replied, "Four." Since that time I have made several other inquiries among my pediatric associates and have been surprised to find how small a number of cases of congenital heart disease they have had in their private practice. Yet if some stranger from another planet should visit Dr. Taussig's clinic, he might well conclude that congenital heart disease is as frequent as measles. The concentration of cases in a few medical centers throughout the country has doubtless given a false impression of the frequency and importance of congenital malformations of the heart. If then the problem represents so small a portion of general pediatric practice, one may fairly ask whether the already overworked children's specialist should undertake an additional burden. He is apt, too, to be discouraged when he contemplates some of the special technics and gadgets which have become popular in cardiac diagnosis. Let me hasten to assure him that his feeling of frustration is no more acute than that of many of us of the older generation when some of our chemical pediatricians begin to toss their atomic weights around and overwhelm us with millimols and milliequivalents. I wish, however, to emphasize the fact that it requires very little time and effort to have a good working knowledge of the diagnosis of most of the congenital cardiovascular anomalies which lend themselves to correction or improvement by surgical means.

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